#ItaconateShunt

Research Projects Publications and Patents of Ron W. Davis, Stanford Genome Technology Center

med.stanford.edu/sgtc/researc...
#ME/CFS #ItaconateShunt
@openmedf.bsky.social @janetdafoe.bsky.social

system’s response to that insult. A central tenet of this hypothesis is that ME/CFS is initiated when the itaconate shunt, normally a temporary response of the innate immune system, becomes a chronic impairment of the tricarboxylic acid cycle (TCA) in affected cells.
#ME/CFS #ItaconateShunt

HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells - Nature Communications Anti-cancer immunity relies on the effector functions (e.g., IFNγ production) of T cells that reside in a hypoxic tumor microenvironment. Here, the authors show that HIF1α-controlled glycolysis is an ...

May be pertinent to #ME/CFS in relation to Phair’s & Davis’ itaconate shunt working hypothesis HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells www.nature.com/articles/s41... See @openmedf.bsky.social www.omf.ngo/regulation-o...
#ItaconateShunt

in activating macrophages by inhibiting succinate dehydrogenase (SDH).

Tomas Paulenda presented at the @investinmeresearch.bsky.social btw.
#ME/CFS
#ItaconateShunt
#TCA

https://www.reddit.com/r/cfs/comments/18pzfis/rob_phair_itaconate_shunt_update_december_2023/?share_id=uKyuueGsTZZLwgSI1t1sB&utm_content=1&utm_medium=ios_app&utm_name=ioscss&utm_source=share&utm_term=...

Rob Phair presented on his Itaconate Shunt Update last year in December 2023 (at the NIH ME/CFS Research Roadmap) : r/cfs Link to a great @Reddit summary of Rob Phair’s #ItaconateShunt MEtabolic hypothesis of #MECFS’ central perturbations: t.co/uZZwbSvXBn