New in JAHA: ASPIRE + expert collaborators outline how #AI could help detect #CardiacAmyloidosis earlier. Strong science. Real-world urgency.
Read more: www.ahajournals.org/doi/10.1161/...
#Amyloidosis #RareDisease #JAHA_AHA

#YAP #VeinGraftDisease

#CyclicStretch (10% strain 1 Hz), or TGFβ1+TSP-1▶️
⏫YAP nuclear enrichment
⏫migration/proliferation/collagen
in👤CD34+CD31- Saphenous Vein progenitors

Verteporfin, YAP/TAZi
⏬intimal hyperplasia
in ApoE*3-Leiden🐭vein graft

#JAHA_AHA 2025
www.ahajournals.org/doi/10.1161/...

Coexisting Calcific Aortic Stenosis and Transthyretin Cardiac Amyloidosis: Real‐World Evaluation of Clinical Characteristics and Outcomes | Journal of the American Heart Association

Worse Outcomes (2-yr mortality, Stroke) of patients with coexisting #AorticStenosis & #TransthyretinCardiacAmyloidosis

>=60 y/o
N=345771 AS only
N=8453 ATTA-CA only
N=1239 AS + ATTA-CA

#AortaEd #CardioTwitter
#JAHA_AHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

#Disulfiram #Atherosclerosis

Inducer of #Autophagy in Mφ/#EndothelialCell/#SmoothMuscleCell/#Hepatocyte, independent of GSDMD

Inhibitor of mouse #Atherosclerosis, likely independent of cholesterol level

+Altered #GutMicrobiota profile

#JAHA_AHA 2024
www.ahajournals.org/doi/10.1161/...

Multiplex imaging of human #Atherosclerosis
Frozen section, PhenoCycler, 9-plex imaging
DAPI, CD45, MYH11, CD68, aCasp3, IL1β, TNFα, BODIPY, CD31

Labeling #SmoothMuscleCell derived #FoamCell vs Leukocyte derived FC in🙍‍♂️coronary arteries Intima

#JAHA_AHA 2024
www.ahajournals.org/doi/10.1161/...

Contaminated Environment and Chemical Exposure Puts Firefighters at Elevated Risk for Adverse Heart and Brain Effects - Beyond Pesticides Daily News Blog (Beyond Pesticides, May 19, 2022) A study published in the Journal of the American Heart Association finds a correlation between the number of fires fought annually and atrial fibrillation (AF), one of the most common medical arrhythmias that increases the risk of stroke, heart failure, and other cardiovascular health issues. In the firefighting occupation, firefighters can experience exposure to chemicals and particulate matter in smoke, pollutants, volatile organic compounds, and polycyclic aromatic hydrocarbons (PAHs) that increase cardiovascular (heart) and respiratory distress risk through oxidative stress and autonomic function disruption. However, firefighters encounter both personal and occupational (work-related) risk factors for cardiovascular diseases, making this subset of the population particularly vulnerable to heart-related fatalities. Considering firefighters live 10 to 15 years less than non-firefighters, studies like these are significant for understanding how chemical exposure contributes to health and wellness disparities. Lead author Paari Dominic, Ph.D., notes, “Clinicians who care for firefighters need to be aware of the increased cardiovascular risk, especially the increased risk of [AF], among this unique group of individuals… The conditions that elevate their risk further, such as high blood pressure, type 2 diabetes, lung disease and sleep apnea, should be treated aggressively. In addition, any symptoms of [AF], such as […]

Study published in #JAHA_AHA finds correlation between no. of #fires fought annually & #atrialfibrillation #AF among #firefighters. Studies like this help show how #chemicalexposure contributes to #health & #wellness #disparities. #pesticides #heartfailure

beyondpesticides.org/dailynewsblog/…