The #cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes. New study from Kaitlyn M. Shen, Parisha P. Shah, Rajan Jain @pennmedicine.bsky.social and colleagues: rupress.org/jcb/article/...
#Chromatin #epigenetics #Disease #lamin #laminopathies
Shen, Shah, Jain et al. @pennmedicine.bsky.social demonstrate that #lamin A/C reduction alters peripheral genome organization in human cardiomyocytes through cytoskeletal forces transmitted by the LINC complex. rupress.org/jcb/article/...
#laminopathies #cytoskeleton #microtubules
In @jcb.org, Shen, Shah, Jain et al. @pennmedicine.bsky.social demonstrate that #lamin A/C reduction alters peripheral genome organization in human cardiomyocytes through cytoskeletal forces transmitted by the LINC complex. rupress.org/jcb/article/...
#laminopathies #cytoskeleton #microtubules
It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
Laminopathies Meeting 2025 wrapped up with two powerful sessions: “Towards Patients” & the Patient Session.
The exchange between experts & patients was incredibly valuable.
Thanks to everyone who joined us!
#Laminopathies #RareDisease #PatientVoices #lmna
Day 3 of the #Laminopathies2025 meeting is underway — our final day! We’re closing strong with sessions focused on patients and patient organizations, followed by a powerful round table discussion. Let’s keep the momentum going 💪🧬
#RareDisease #Patient #laminopathies
Day 2 of the #Laminopathies conference is underway! 💡 Dive into today’s sessions and connect with the global community driving progress in laminopathy research. Full program available at laminopathies.net
#RareDisease #Laminopathy #Laminopathies
An unforgettable evening at the #Laminopathies conference gala dinner/cocktail party - great conversations, inspiring connections, and a stunning venue. Huge thanks to the organisers and @LmnaCardiac for bringing this community together! 💙 #RareDisease #Laminopathy #lmnacardiac
The #Laminopathies Meeting is LIVE!
Experts, researchers & advocates are gathering to push forward breakthroughs in LMNA & lamin-related diseases. Follow the latest updates, science, and community highlights 👉 Laminopathies.net
#Laminopathies2025 #RareDisease #LMNA #lmnacardiac
We start tomorrow! 🧬
The Laminopathies Meeting begins with registration at 14:00 — we’re looking forward to seeing you all there!
More info: laminopathies.net
#Laminopathies #RareDisease #LMNA #Genetics #PatientCommunity
🚨 The Laminopathies Meeting will also be available online! 🌐
🗓️ Join virtually via Zoom webinar:
👉 zoom.us/j/96240745334
Don’t miss this key event for the laminopathies community — whether you're a researcher, clinician, patient, or advocate. laminopathies.net 💻
#Laminopathies #LMNA #VirtualEvent
We’re excited to see many of you in Paris next week!
If you can’t make it in person, don’t worry—follow us here and on our website for access to the live stream.
#laminopathies #lmna #paris #livestream
Welcome to the official account for the 5th Laminopathies Conference! 🧬 Join us for cutting-edge research, inspiring talks, and live updates from the Laminopathies meeting in Paris. Follow for the latest news! #Laminopathies2025 #laminopathies #lmna #lmnacardiac
Read more 👉 pubs.aip.org/aip/jcp/arti...
#CellBiology #Laminopathies #HGPS #NuclearMechanics #Research #Biophysics
