Interested in #LungPath? Don’t miss HSCP’s Annual Spring Symposium in Houston next month! 😆🔬🫁

Hear from incredible speakers, including @smlungpathguy.bsky.social, and connect with leaders in the field!

#pathology #MDACCPath

Melanomas arising in blue nevi exhibit absence of TERT promoter mutations, low tumor mutational burden, and high frequency of distant metastases and disease-related mortality: a clinicopathologic and ... Melanoma arising in blue nevus (MBN) is a rare melanoma subtype with distinct molecular characteristics and biological behaviors compared to other cutaneous melanomas. However, limited data exists on ...

🚨 Hot off the press! What a timely delivery during #USCAP2026. This is one of the very first molecular characterizations of true MBNs in one of the largest cohorts ever studied. Open access. Check it out if you love #dermpath & #molepath! 😆🔬🧬 #MDACCPath

link.springer.com/article/10.1...

My very 1st USCAP meeting was 9 years ago in San Antonio, and it opened my eyes to the possibility of a career in academic #pathology.

Residents, please attend #USCAP2026 if at all possible. It could truly change your career path! #dermpath #MDACCPath

Bonus: what do you 👀?

Melanoma With RNF11::BRAF Fusion: A Novel Fusion Previously Undescribed in Melanoma - PubMed B-Raf Proto-Oncogene ( BRAF ) fusions are rare in melanomas. We present a case of cutaneous melanoma with a Ring Finger Protein 11 ( RNF11 ) ::BRAF fusion in a 63-year-old man with a history of stage IB melanoma on the right upper back (pT2apN0cM0; nonulcerated with a Breslow thickness of 1.2 mm). D …

The presence of a gene fusion doesn’t always indicate a Spitz melanocytic neoplasm. Here’s our example featuring the new RNF11::BRAF fusion in non-Spitz melanoma. Check it out if you love #dermpath and #molepath! 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40036483/

What a pleasant surprise! Our article has been selected as the front cover of this month’s issue of JPTM. I’m glad that the editorial team was impressed by the comprehensiveness of our review article and its high-quality images. 😆🔬

#dermpath #MDACCpath

jpatholtm.org/journal/view...

INSM1: A highly sensitive marker for primary and metastatic Merkel cell carcinoma, superior to SOX11, pancytokeratin, and CK20 - PubMed Detection of Merkel cell carcinoma (MCC) micrometastases in sentinel lymph nodes (SLNs) often necessitates immunohistochemical studies like pancytokeratin (panCK) or CK20. However, panCK can label non-epithelial cells, particularly dendritic reticulum cells, complicating interpretation, while CK20 i …

Want to maximize Merkel cell carcinoma detection in sentinel lymph nodes? Go with panCK + INSM1 or panCK + SOX11. CK20’s sensitivity is just too low; its expression can be absent in up to 24% of MCCs. Check it out if you love #dermpath and #IHCpath. 😆🔬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40505699/

#USCAP2026 in TX is just around the corner! 😆🔬🤠

Excited to connect with incredible pathologists and #pathology trainees and to see the latest studies in #dermpath.

As a bonus, here’s a special stain that turned into a bit of pareidolia. 👀
What do you see in it? #MDACCPath

NSD3::FGFR1 : A Novel Gene Fusion First to Be Described in Merkel Cell Carcinoma - PubMed Merkel cell carcinomas (MCCs) exhibit diverse molecular profiles, often categorized by their association with Merkel cell polyoma virus (MCPyV). MCPyV-associated MCCs typically display a low tumor mutational burden (TMB), lacking both somatic mutations and ultraviolet signature. By contrast, MCPyV-n …

When was the last time you encountered a gene fusion in Merkel cell carcinoma?

Here is the first documented case of MCPyV-positive MCC harboring a novel NSD3::FGFR1 gene fusion. Check it out if you love #dermpath and #molepath! 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40036479/

<em>JEADV Clinical Practice</em> | Clinical Dermatology and Venereology Journal | Wiley Online Library Click on the article title to read more.

Endocrine mucin-producing sweat gland carcinomas presenting as blue-gray papules, as reported by Likki et al. 😆🔬

#dermpath #dermatology #pathology #MDACCPath

onlinelibrary.wiley.com/doi/10.1002/...

Diffuse cutaneous ALK-immunoreactive histiocytosis with MEF2C::FLT3 fusion - PubMed Diffuse cutaneous ALK-immunoreactive histiocytosis with MEF2C::FLT3 fusion

We share our experience with an unusual, diffuse cutaneous ALK-immunoreactive histiocytosis with a MEF2C::FLT3 fusion. Check it out if you love the #dermpath and #molepath combination. 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/41211348/

The evolving role of TRPS1 in dermatopathology: insights from the past 4 years - PubMed Over the past 4 years, trichorhinophalangeal syndrome type 1 (TRPS1) has rapidly gained attention among practicing pathologists, with numerous studies emerging that both support and question its diagnostic utility. Initially regarded as a highly specific marker for tumors of mammary origin, TRPS1 is …

Lastly, when in doubt, read this most comprehensive review on TRPS1 #IHCPath, which incorporates our extensive experience with this marker over the past 4–5 years in #dermpath. Free access! 😆🔬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/41605620/

TRPS1 expression in primary and secondary extramammary Paget diseases: An immunohistochemical analysis of 93 cases - PubMed Extramammary Paget disease (EMPD) predominantly manifests de novo as primary EMPD, with less than 30 % of cases associated with underlying internal malignancy (secondary EMPD). Differentiating primary from secondary EMPDs based solely on histopathology poses challenges, often necessitating supplemen …

And this was by far the largest study on this topic, including more than 90 cases of EMPD, and it was the first to demonstrate that primary perianal EMPDs lack TRPS1 expression, an important diagnostic pitfall. 😆🔬

#MDACCPath #dermpath

pubmed.ncbi.nlm.nih.gov/38000676/

Immunohistochemical expression of TRPS1 in mammary Paget disease, extramammary Paget disease, and their close histopathologic mimics - PubMed TRPS1 may be useful to distinguish MPDs/EMPDs from MISs, but its utility is limited in distinguishing them from other pagetoid intraepidermal neoplasms such as SCCISs.

This was the very first study on this topic by #MDACCPath #dermpath published in 2023. 😆🔬

pubmed.ncbi.nlm.nih.gov/36808637/

🚨 Hot off the press! The most comprehensive open-access review of TRPS1 and its applications in #dermpath is now available. Everything you need to know, based on our 4+ years of experience, is in one place. Check it out! 😆🔬

www.jpatholtm.org/journal/view...

#MDACCPath #IHCPath #TRPS1

Looking for a unique #pathology fellowship experience? 😆🔬

#MDACCPath has spots open! You’ll see once-in-a-lifetime cases (quite often) and learn from some of the best in the field.

If you’re even a little interested, apply! You won’t regret it.

It’s been a while since I shared a case.

Did you know this immunoprofile, especially the diffuse TRPS1 immunoreactivity, strongly favors primary EMPD over secondary EMPD? Give it a try if you haven’t used it in your practice. 😆🔬

#dermpath #IHCPath #MDACCPath

🚨Spoiler alert: Here’s a key pitfall almost no #dermpath textbook covers—SPTCLs can often show marked gamma/delta T-cell populations, mimicking pcGDTCL. A diagnostic trap you’ll want to know about. Our paper is coming soon—stay tuned! 😆🔬

#dermpath #hemepath #MDACCPath

🚨Spoiler alert: Primary cutaneous NUT adnexal carcinoma can metastasize—but long-term outcomes remain unclear. We're about to report an almost 20-year follow-up on this new entity. Stay tuned! 😆🔬🧬

#dermpath #pathology #molpath #IHCPath #MDACCPath

Exciting news! The May issue of The American Journal of Dermatopathology is out, and our paper is featured on the cover! What a great way to kick off the month. That gene fusion schematic? Pretty much our signature move at this point! 😆🔬🧬🎉

#dermpath #pathology #molepath #MDACCPath

Shoutout to our amazing #MDACCPath #IHCPath team for making work fun! 😆🔬🎨🎉

We had an Easter egg hunt in the lab, and I got to decorate my microscope with the treasures I found. Wishing everyone a joyful Easter weekend! 🐣🪺

#pathology

Happy Friday #dermpath! 😆🔬

Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉

#MDACCPath #molepath #pathology

Weekend non-#dermpath special. 😆🔬

Here are photogenic intracytoplasmic inclusions or morulae ("mulberry-like" microcolonies of bacteria) in human granulocytotropic anaplasmosis (formerly known as human granulocytic ehrlichiosis). 🐛🧫🦠

#pathology #hemepath #MDACCPath

Do you see what I see? 😆🔬

Pseudoepitheliomatous hyperplasia and dermal granulomatous inflammation with multinucleated giant cells. That’s it? Nope, keep looking and you will find the cause of these histopathologic changes—Medlar bodies of chromoblastomycosis!

#dermpath #IDpath #MDACCpath

New Year #dermpath special! 😆🔬

What about a case of Merkel cell carcinoma showing diffuse DLL3 (delta-like protein 3) expression?

DLL3 is under investigation as a potential biomarker for DLL3-targeting antibody-drug conjugates.

#IHCPath #MDACCPath #pathology

Thursday #DermPath special! 😆🔬

Many tumors unfortunately can metastasize to the skin, including this one. 😫

Cutaneous metastasis of pancreatic adenocarcinoma showing complete loss of DPC4 expression.

#MDACCPath #pathology #GIpath #IHCpath