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#Darmgesundheit #Metabolite #Ganzheitsmedizin

Intriguing 2025 article by Li et al.:

‘Drought-induced plant microbiome and metabolic enrichments improve drought resistance’

tinyurl.com/bdf24h3b

#WIS

#PlantandEnvironmentalScience

#Ecosystem

#Ecology

#DroughtResponse

#ClimateChange

#Metabolite

#Wheat

#Crop

Graphical abstract

🚨Publication alert🚨

Together with Hannah Thomas, Andrew Sewell, Nicola Ternette and colleagues, we present a step-by-step workflow for trapping and identifying MR1-presented #metabolite #antigens, by chemical #crosslinking and #proteomics.

#teammassspec

www.sciencedirect.com/science/arti...

Definition of Metabolite: Size as a Critical Criterion Metabolites have traditionally been defined as organic molecules smaller than 1500 daltons (Da). However, recent advances in analytical technologies and chemoinformatics have uncovered a wider chemical diversity, including biologically significant metabolites exceeding this conventional size cutoff─such as polypeptides, glycosphingolipids, and bacterial lipopolysaccharides. Detecting these larger metabolites challenges standard metabolomics approaches and necessitates optimized mass spectrometry acquisition parameters. In this perspective, the analysis of multiple databases (HMDB blood, GNPS, Plant Molecular Network [PMN], Natural Product Atlas [NPA] fungi, NPA bacteria, and MiMeDB) confirms that although most metabolites are below 1000 Da, notable populations exceed this threshold, particularly in bacterial data sets. Furthermore, reanalysis of liquid chromatography–mass spectrometry (LC-MS2) data sets from diverse biological samples, especially bacteria-rich matrices like feces and skin, reveals features (peaks with m/z and retention time) extending beyond 1500 m/z. These findings underscore that metabolites are often larger than commonly recognized in the literature. Therefore, the definition of metabolites should evolve to accommodate their size diversity, ensuring accurate knowledge dissemination to new generations of metabolomics researchers.

🚀 New perspective published

How big are metabolites?

Why is the 1500 Da size cut-off commonly used?

I hope you enjoy it

PD: DM if a copy is needed

#metabolomics #metabolite

Definition of Metabolite: Size as a Critical Criterion | Journal of Proteome Research pubs.acs.org/doi/10.1021/...

While AML cells express EAAT1, the transporter was not needed for AML growth or survival after #chemotherapy, neither in cell cultures nor in a mouse model. Our results further indicate that AML cells possess multiple mechanisms to acquire #aspartate, underscoring the importance of this #metabolite!

In a study published on January 1, 2026, in the journal Horticulture Research, scientists applied single-nucleus RNA sequencing to tea buds and successive leaves.
#RNA-Seq #Metabolite synthesis
Details: doi.org/10.1093/hr/u...

γ-Aminobutyric Acid (GABA): Metabolite, Messenger, and Mediator of Stress Adaptation γ-Aminobutyric acid (GABA), a nonproteinogenic amino acid first identified in biological systems over 70 years ago, has long been recognized as a metabolic intermediate. More recently, GABA has also b...

γ-Aminobutyric Acid (#GABA): #Metabolite, Messenger, and Mediator of Stress #Adaptation

www.annualreviews.org/content/jour...

#PlantScience #SciComm @annualreviews.bsky.social @asps-oz.bsky.social @blackinplantsci.bsky.social @efsa-plants.bsky.social @sebbm.bsky.social @hiroshi-maeda.bsky.social

#Gut-derived #metabolite #hippuric #acid 'turns up' #immune #inflammation, study finds

Wistar scientists found hippuric acid, a gut metabolite from plants, boosts immunity early in infections but can trigger deadly sepsis as the illness progresses.. scitechupdates.com/g...

Asaph Aharoni:

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

#Carpel

Legend for figure 4

auxins (AUXs), cytokinins (CKs), ethylene (ET), gibberellins (GAs), abscisic acids (ABAs), jasmonates (JAs), salicylates (SAs), brassinosteroids (BRs), and strigolactones

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

#Carpel

Fig.4B

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

#Carpel

#Stamen

#Anthesis

Fig.4A

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

#Carpel

#Stamen

Fig.1C

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

Fig.1B

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

Exciting new paper with Asaph Aharoni as co-author:

“Hormone-centric multi-omics atlas of flower and early fruit development in tomato“

tinyurl.com/2ckpjdb2

#WIS

#PlantandEnvironmentalSciences

#Tomato

#Anthesis

#Hormone

#Metabolite

#Metabolome

Fig.1A

#JJC2026 Axelle Deroubaix (@inrae-bioger.bsky.social) on the role of a #metabolite produced during the #biotrophic phase of #Colletotrichum higginsianum infection

This #JournalClub by Laure Haenebalcke & Jeppe F. Vigh-Larsen examines the work of Blervaque et al. (2025) in relation to mean capillary-to-muscle diffusion distance as a limitation for #oxygen uptake and #metabolite exchange

🔗 Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Catherine Phelps from @upmc.com representing #SITC Talks on how #exercise can improve outcome - role for #microbial #metabolite #formate on mediating #anticancer #immunity / #WIC2025 #SITC2025

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the e...

🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice.
🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production.
🧑‍💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis.
🔗 doi.org/10.1002/imo2...
#microbiome

#Metabolite and #Hormone levels of wild populations can be monitored non-invasively through faeces. This study examines the distribution of hormones through #KillerWhale 🐳 faeces to see if small volume samples are enough to give a good picture of metabolites

Full paper: doi.org/10.1093/conp...

Relational Graph Convolutional Network for Robust Mass Spectrum Classification Supervised machine learning methods have shown impressive performance in interpreting mass signals and automatically segmenting spatially meaningful regions in Mass Spectrometry Imaging (MSI). Such se...

Clever way to use high res mass spec data for #metabolite networks in spatial #metabolomics data
pubs.acs.org/doi/10.1021/...

🧪 #Metabolomics Week spotlight!

Our Metabolomics Unit, led by @alaaothman.bsky.social, offers end-to-end metabolite analysis support - from experimental design to data interpretation. Services include #lipidomics, targeted & untargeted #metabolite analysis.

🔗 tinyurl.com/5a74hrpn

MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens Schmidlin et al. present a method for the discovery of metabolite antigens presented by major histocompatibility complex class I-related protein (MR1) by chemical cross-linking and subsequent mass spe...

🚨Publication alert - out today!🚨

Have you ever wondered if you could do #metabolite #antigen #discovery by chemically #crosslinking the antigen to the antigen presenting molecule #MR1?

We did!

And it works a treat - check out our new methodology :)

#teammassspec

www.cell.com/cell-reports...

A research team published a study on August 3, 2024, in Horticulture Research, employing MALDI-MSI to visualize the spatial distribution of 1,234 metabolites in tea seedlings.
#metabolite distribution #tea seedlings
Details: doi.org/10.1093/hr/uhae218

#Pyruvate decarboxylase and its #lysine succinylation contribute to the #development and #metabolite biosynthesis in pathogenic fungus #Aspergillus flavus
doi.org/10.1080/2150...
@tandfresearch.bsky.social

A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy - Nature Cell Biology Gross et al. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex via Atg11 to promote Atg11...

As my #NewPI journey is starting I re-share my latest publication: 👉We uncovered a #phosphate #metabolite sensor, binding and regulating the #autophagy Atg1/ULK1 initiation complex to regulate #pexophagy in response to
phosphate availability. nature.com/articles/s41556-024-01348-4

This new Short report studies trans-right #ventricle #metabolite gradients in individuals with #obesity and identifies representation of molecular pathways including #fattyacid oxidation, #bileacids and #acylcarnitines.

doi.org/10.14814/phy...

Asking #naturalproduct #metabolite people - Is there a tool to predict MS/MS spectra of macrolides? I guess Sirius can be used to predict structure from MS/MS ...any directions would be helpful #massspec #secondarymetabolites
@pieterdorrestein.bsky.social @gnps2.bsky.social @kateduncan.bsky.social

Our latest #reviewarticle: The role of UV-B radiation in modulating #secondarymetabolite #biosynthesis & regulatory mechanisms in #medicinalplants

bioresources.cnr.ncsu.edu/resources/th...

#BioResJournal #OpenAccess #UVBradiation #Metabolite #photoprotection

Our very talented PhD student Fanzhou Kong published at nature method "Denoising Search doubles the number of #metabolite and #exposome annotations in human plasma using an #Orbitrap Astral mass spectrometer"
www.nature.com/articles/s41...
@jjjvanderhooft.bsky.social @mingxunwang.bsky.social