The SAG101–NRG1 branch of TIR signaling activates phenylalanine‐derived SA biosynthesis in Nicotiana benthamiana Unlike Arabidopsis, Nicotiana benthamiana uses the SENESCENCE ASSOCIATED GENE 101– N REQUIREMENT GENE 1 branch of TIR signaling to activate salicylic acid biosynthesis, illustrating evolutionary dive...

🛡️Xu et al. reveal a striking #evolutionary divergence in the regulatory mechanisms of salicylic acid #biosynthesis between N. benthamiana and #Arabidopsis.
⬇️Get a free sneak peek at this new work right here!
⚔️ doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantScience #CropSci #JIPB

Diagram featuring a choloroplast/plastid, ER, cytosol, and nucleus, illustrating how the O-methyltransferases FsE4MT01 and FsE4MT02, and the glycosyltransferase FsP4′GT catalyze the terminal methylation and glycosylation steps in biosynthesis of the unique antiviral lignan phillyrin in Forsythia suspensa.

🧪Phillyrin is a unique #antiviral lignan with potent anti-#flu activity only found in Forsythia suspensa.
Wang et al. reveal key steps in its #biosynthesis, bringing us one step closer to a valuable #drug.
🔗 doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #JIPB #plant #medicine

New work in #RESInsectMolecBio

Identification & functional characterization of key #ecdysteroid #biosynthesis & signalling genes regulating #moulting & #metamorphosis in #Dastarcus helophoroides
doi.org/10.1111/imb.70035

@sassanasgari.bsky.social @gulianusslab.bsky.social @wileyecology.bsky.social

Image of a promotional poster for the event "Directing Biosynthesis VIII" by the Royal Society of Chemistry. Scheduled for 29 June - 1 July 2026 in Manchester, UK. Poster abstract deadline: 20 April 2026. Features a plant with molecular structures overlay.

Show us your latest biosynthesis research and get instant feedback.

Network with peers and leading researchers and discuss cutting-edge research at Directing Biosynthesis VIII #Biosynthesis.

Submit your poster abstract today: rsc.li/dbviii #DBVIII #ChemSky

Research progress on the main bioactive components and their corresponding biosynthetic enzymes in Cyclocarya paliurus Cyclocarya paliurus (Batalin) Iljinsk., a medicinal and edible plant widely utilized in China, is a rich source of triterpenoids and flavonoids, which…

What makes medicinal plants chemically unique? 🌿

A CJNM review decodes the biosynthesis of Cyclocarya paliurus, highlighting its triterpenoids, flavonoids & signature C-11 glycosylation — with a genomic-biochemical roadmap for future engineering.

#NaturalProducts #Biosynthesis #PlantScience #CJNM

What are terpenes? - Université Jean Monnet

What are terpenes? 🤔

🔎Where can we find them?

✅What are they used for in Nature? By Humans?

These are the questions we answer in our first website article! Go read it right now⬇️

#terpenes #terpenoids #outreach #science #article #easy #plants #pollinator #ecology #biosynthesis

#Biosynthesis of #sporogen-AO1 reveals #P450-catalyzed diversified oxidation steps in #Eremophilane family #sesquiterpenoids
doi.org/10.1080/2150...
@tandfresearch.bsky.social

I forgot to ad hashtags!! #Biosynthesis #Olive #plantscience #NaturalProducts #SecMet
I may have to repost this later this week; anyone know hashtags on natural product biosynthesis or enzyme/gene discovery?

Phosphorylation fine‐tunes ceramide synthase activity and stability to modulate sphingolipid biosynthesis and immune responses Phosphorylation fine tunes the activity and stability of the ceramide synthase LOH2, enhancing pathogen resistance by increasing ceramide biosynthesis, salicylic acid accumulation, and pathogenesis-r...

Ceramide synthases are crucial to sphingolipid #biosynthesis and multiple aspects of #plant #development and #pathogen #immunity.
In a fascinating new study, Zhang et al. explore regulation of CerS activity in #Arabidopsis.
🔗 doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantScience

New paper out in JACS!

“Myxarylin: Total In Vitro Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides”

DOI: 10.1021/jacs.5c17257

We reconstitute a minimal biarylitide RiPP pathway and reveal the plasticity of P450 BytO.

#NaturalProducts #Biosynthesis #RiPPs

Generation of halogenated angucyclinones with cytotoxicity activities against human cancer cell lines based on biosynthesis and chemical conversion Halogen substituents play a crucial role in the structural diversity and biological activity of natural products, and the synthesis of halogenated mol…

⚗️ New strategies in halogenated natural products!
CJNM reports a method to incorporate F, Cl, Br, and I into C-ring-cleaved angucyclinones, efficiently producing bioactive molecules for cancer research.

🔗 Read on ScienceDirect!

#CJNM #Biosynthesis #HalogenatedNaturalProducts #CancerResearch

TgRAV1–TgWRKY74–TgACS13 module fine‐tunes ethylene biosynthesis to modulate waterlogging‐induced root vitality in the gymnosperm Torreya grandis Under waterlogging stress, the TgRAV1–TgWRKY74 regulatory module in Torreya grandis modulates expression of the ethylene biosynthesis gene TgACS13 through multiple mechanisms to control ethylene accu...

In #gymnosperms, #root #anatomy and #physiology makes it challenging to survive #ClimateChange -induced waterlogging.
Yan et al. identify an ethylene #biosynthesis transcription factor module that may help #PlantScience change that.

doi.org/10.1111/jipb...
@wileylifesci.bsky.social

Antheia Secures $24 Million to Boost Pharmaceutical Manufacturing and Innovation Antheia has raised an additional $24 million, bringing its total funding to over $175 million aimed at enhancing pharmaceutical manufacturing in the U.S.

Antheia Secures $24 Million to Boost Pharmaceutical Manufacturing and Innovation #USA #pharmaceutical #Menlo_Park #Antheia #biosynthesis

GeARF5/GeIAA33‐GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata Auxin signaling regulates the formation of vegetative propagation corms in Gastrodia elata by regulating sugar-acid interconversion, which in turn regulates polysaccharide and starch biosynthesis as ....

[📰 Paper] GeARF5/GeIAA33-GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in 𝐺𝑎𝑠𝑡𝑟𝑜𝑑𝑖𝑎 𝑒𝑙𝑎𝑡𝑎

@cnrs-rhoneauvergne.bsky.social @vocspop.bsky.social

#paper #medicinalplant #science #biosynthesis #gastrodia #transcriptomic

Dissecting the biosynthesis, regulation, and metabolic engineering of steroidal glycoalkaloids in tomato This mini-review synthesizes recent advances in the biosynthesis and regulation of tomato steroidal glycoalkaloids and discusses the potential applications of metabolic engineering for targeted modul...

🍅 It's #TomatoTuesday on Thursday!
🍅This time,🍅we join🍅Chen et al. as they investigate the #biosynthesis, regulation, and metabolic #engineering of #antifungal, #antibacterial,🍅and #anticancer compounds in #tomato.🍅
🍅 doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #SynBio #Pharming

Directing Biosynthesis VIII - submit your oral abstract by 2 February 2026

Share your latest biosynthesis research!

Directing Biosynthesis VIII is the perfect place for you to network with peers and leading researchers in the field of #Biosynthesis with our invited speakers.

Submit an oral abstract: rsc.li/dbviii #DBVIII #ChemSky

Modification of starch synthesis in food crops using CRISPR/Cas9 gene editing technology for changing climate - Stress Biology Starch is a principal storage component in plants, significantly influencing the yield and quality traits of major crops. Climate change, particularly drought and high temperatures, severely affects s...

Modification of starch synthesis in food crops using CRISPR/Cas9 gene editing technology for changing climate

Liangjie Niu, Hui Liu … Xiuli Hu & Wei Wang

link.springer.com/article/10.1...

#Crops #Biosynthesis #ClimateResilience #GeneEditing

Don't miss your chance to present your research at Directing Biosynthesis VIII!

⏳Time is running out until the oral abstract deadline on the 2nd of February▶️ rsc.li/dbviii

Be sure to join us and the rest of the #Biosynthesis community in Manchester this summer

#natprod #secmet #DBVIII

Zhu et al. engineered Y. lipolytica to achieve enhanced de novo #biosynthesis of neohesperidin, which was subsequently integrated with a chemical conversion system to establish a scalable #biochemical process for high-yield NHDC production at an industrial scale.
doi.org/10.59717/j.x...
#foodtech

#Review
Pro-resolving lipid mediators in #diseases: exploring the molecular basis and clinical implication doi.org/10.1186/s435...

This review summarize the current advances in #PRLM #biosynthesis, signaling pathways, biological functions, and emerging #TherapeuticStrategies...

Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...

#Mitochondrial control of #fuel switching via #carnitine #biosynthesis | Science www.science.org/doi/10.1126/...

CsHCT synthesizes acylated flavonoid, kaempferol‐3‐O‐(6″‐p‐coumaroyl)‐glucoside, to enhance cold resistance in tea plants (Camellia sinensis) The acylated flavonoid kaempferol-3-O-(6”-p-coumaroyl)-glucoside, a newly characterized compound in tea plants, accumulates mainly in young leaves, is stable during black tea processing, is produced ...

🫖You can't beat a good cup of tea! ...how about some #PlantScience to go with it?

Liu et al. describe the #biosynthesis of acylated flavonoids in #tea plants and highlight CsHCT as a #genetic target for enhancing #cold resistance.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social

Proposed model for the regulation of abscisic acid biosynthesis by indole-3-acetamide (IAM).

IAM triggers ABA #biosynthesis and signaling in #Arabidopsis #thaliana

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
by Moya-Cuevas et al.

@stephanpollmann.bsky.social @WIleyPlantSci #PlantScience

New research in #RESInsectMolecBio

Carbohydrate #biosynthesis pathway is associated with lineage-specific #diapause termination in the #silkworm, #Bombyx mori
doi.org/10.1111/imb.70015

#Ontology #DEGs #WGCNA #Sericulture
@sassanasgari.bsky.social @gulianusslab.bsky.social @wileyeco.bsky.social

Methylation of isopentenyl pyrophosphate by C‐methyltransferase and optimizing irregular β‐elemene yield using UniKP, an enzyme kinetic parameter prediction tool Methylated β-elemene was produced in engineered E. coli using multiple methods, including screening of C-methyltransferases and evolution of germacrene A synthase with UniKP, as well as cofactor engi....

Need a little late-weekend magic?🪄
🌱Well, we're #plant #scientists, so you're getting the "Magic #Methyl Effect."🧪

Li et al. explore key factors in the #biosynthesis of irregular #terpenes and more! Get a pre-pub sneak peek here! ⬇️

doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantScience

This review summarizes LPA signaling, from #Biosynthesis and receptor pathways to #TherapeuticTargets, and presents an AI model that simulates network dynamics for predictive and #PersonalizedTreatment. #medsky @ou.edu

#STTT #OpenAccess: doi.org/10.1038/s413...

Directing Biosynthesis VIII - submit your oral abstract by 2 February 2026

Oral abstract submission is now open for Directing Biosynthesis VIII, an event that has been connecting #Biosynthesis researchers for over a decade.

Network and discuss the latest research, get all the details and submit: rsc.li/dbviii

#DBVIII #ChemSky

Discovered UGT738A3 gene boosts polyphyllin synthesis, reconstructed pathway in yeast for 0.13 mg/L yield. #Biosynthesis #Polyphyllins
Details: doi.org/10.1016/j.bidere.2025.100047

Cannabinoids Produced From Yeast renewable-carbon.eu/news/?p=169739 #biodiesel #biosynthesis #cannabinoids #phytopharmaceuticals #yeast #RenewableCarbon

Screenshot of the JIPB webpage detailing a call for papers for the upcoming special issue, Advances in Plant Natural Products: Biosynthesis, Bioengineering, and Applications.

🎃 Have you picked your Halloween costume? 🎃 And more importantly, have you submitted your papers to our upcoming special issue on Advances in Plant Natural Products: #Biosynthesis, #Bioengineering, and Applications.

jipb.net/EN/news/news...

#PlantScience #medicine #food #SynBio #agriculture