How can nature make #peptides covering chemical space beyond the proteinogenic amino acids using the #ribosome?

Wilfred van der Donk talked at #Biochemistry2026 about the power of ribosomally-synthesized and post-translationally modified peptides #RiPPs.

pubs.rsc.org/en/content/a...
#Biochemistry

New paper out in JACS!

“Myxarylin: Total In Vitro Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides”

DOI: 10.1021/jacs.5c17257

We reconstitute a minimal biarylitide RiPP pathway and reveal the plasticity of P450 BytO.

#NaturalProducts #Biosynthesis #RiPPs

Thank you @mmzdouc.bsky.social for detailing our work!
In this study we highlight conserved & unique #clusters and link 5 #lichen #metabolites to #BGCs.
Thank you @marnixmedema.bsky.social & all the collaborators 🥂!
#PKSs #RiPPs #secondaryMetabolism #depsides #fungi #MS #omics

We also show that lichen are surprisingly diverse in putative ribosomally synthesized and post-translationally modified peptides #RiPPs, with roughly 1/5 of detected BGCs. They generally show low similarity with reported fungal RiPPs, representing a putative hotspot for discovery. (3/5)

Biosynthesis of peptide–nucleobase hybrids in ribosomal peptides - Nature Chemical Biology Naturally occurring peptide–nucleobase hybrids are rare. Here Pei et al. report the discovery and biosynthetic studies of the first peptide–nucleobase hybrid catalyzed by an RRE–YcaO–dehydrogenase com...

Some other recent work was this collaboration led by the Nair lab, where we showed how a nucleobase-peptide hybrid is generated from a ribosomal precursor peptide via YcaO domain protein catalysis
#RiPPs #biosynthesis #Streptomyces
www.nature.com/articles/s41...