This often results in #microcephaly, developmental delays, premature aging, and an increased predisposition to tumours.

To study the origin of these symptoms, the team used the #Drosophila fly as a model.

A study led by Dr. Marco Milán, @icreacommunity.bsky.social researcher at #IRBBarcelona, has identified the cellular mechanism explaining why certain errors in chromosome division can lead to #microcephaly, a condition where the brain develops to a smaller-than-average size.

🔬 #Mitochondria identified as key player in a #RareDisease causing #microcephaly.

Published in 📰 @natcomms.nature.com

➡️ bit.ly/4sMO85i

📌 DOI: s41467-026-70521-0

#IRBScience @milanlab.bsky.social @icreacommunity.bsky.social @cerca.cat @bist.eu @sommalliance.bsky.social @www.pcb.ub.edu

🧵👇

#rarediseaseweek2026 #rarediseaseday #microcephalyawareness #rareparenting #ugandahealth #inclusionmatters #firsttimeparents | Care Beyond Limits-Microcephaly Africa Foundation More Than a Diagnosis: Charles and Ernest’s Journey with Microcephaly 🇺🇬 ​Being a first-time parent is a journey into the unknown. But for Charles and his wife in Uganda, that journey took an unexpec...

​Meet Charles, a father in Uganda navigating #Microcephaly with his son, Ernest. As first-time parents, he and his wife are redefining "normal", proving that a diagnosis doesn't define a child's potential.
​A story of hope & strength.
​#RareDiseaseDay #Microcephaly
www.linkedin.com/posts/raredi...

The figure shows staining of mouse embryos with X-gal to highlight Ttc21b in whole-mount embryos (panels A-D,H) or after sectioning (panels E-G,I-N). Boxed areas in panel E are shown magnified in panels F and G, boxed areas in panels I and L are shown magnified in panels J and M. Arrows indicate specific areas of lacZ expression.

Rebekah Niewoehner, Rolf Stottmann & co found that pathogenic Ttc21b variants, the primary #cilia gene, contribute to primary #microcephaly, with homozygous #mouse mutants showing severe #microcephaly due to impaired neural progenitor proliferation and differentiation.

Read doi.org/10.1242/dmm....

Rare" is a misnomer. While individual diseases may be rare, the community living with them is massive, 1 in 10 people worldwide.

​Read through our infographic to see the startling facts about rare diseases.

​​#RareDiseaseWeek #RareIsMany #PublicHealth #HealthData #rarediseaseday #Microcephaly

This support means a lot to us, not just as funding, but as trust in the work we’re doing. Building on the results we got in a former Telethon project, we aim now at optimizing an #oligodendroglia cell replacement strategy to sustain #neurodevelopment in a preclinical model of #microcephaly MCPH17

Primary cilia as architects of the neocortex: Roles in brain development, function, and microcephaly In this perspective article, Thomsen et al. discuss how primary cilia coordinate neocortical development, function, and regeneration. They highlight emerging links between ciliary control of neural pr...

Our last review is out today!
It was a fantastic team effort with my friends in Copenhagen, especially Søren Christensen @sorentc.bsky.social and Lars Allan Larsen. A very special thank you to Oskar for his excellent work on the final version! #cilia #microcephaly

www.cell.com/developmenta...

These Zika mothers went to battle -- and their cry was heard — NPR After the Zika outbreak ended in Brazil, many families faced a new reality: a child whose life was irrevocably altered after the mother contracted the virus while pregnant. Here's what happened next.

apple.news/AaFZ9X_4FRw-...
#Brazil
#Zika-babies
#dano-moral reparations
#microcephaly

Born different: The untold story of Kilifi’s children with microcephaly For years, Kilifi parents were told their children’s small heads were a curse, hindering them from seeking medical support

Behind every child with Microcephaly is a mother grappling with rejection, poverty and no answers. Their resilience deserves recognition and action.

Read the full story → nation.africa/kenya/health...
#Microcephaly #RareDiseaseAwareness #CareBeyondLimits

Especially the ones that live with #RARE neurological disorders like #Microcephaly!

#somethingcanbedone!
@who.int

Zika virus may raise long-term risks of type 2 diabetes – new study New research from Brazil links Zika to lasting brain and insulin changes.

#Zika #virus may raise long-term risks of type 2 #diabetes ...

| #Brazil | #infections | #microcephaly | #brain | Via @theconversation.com

CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...

by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University

Recent outbreaks #ZIKV have been associated with increased incidences of neurologic complications such as Guillain-Barré syndrome #GBS and a spectrum of perinatal complications and developmental disorders such as #microcephaly and motor deficits

Big congrats to Maryam K. Ardakani who defended her PhD thesis on approaches targeting #oligodendroglia in models of primary autosomal recessive #microcephaly 17!

And a big thank you to Prof. F Ferrini (UniTo), Prof. A Frasca (UniMi), Prof. De Meffre (Université Paris Cité) for serving as commitee!

24 HOURS till #CanFly2025, and we're spotlighting a must-read on Asp/ASPM proteins! From #fly to #human, these spindle players may be moonlighting in interphase 👀 Could cyclin–CDK regulation explain their dual lives?
doi.org/10.1139/gen-...
#CellCycle #Microcephaly

HEY, Elon Musk! STOP BREEDING. It's time to put an END to Microcephaly once and for ALL.
My apologies to Schlitzie for posting His image next to that of a Flaming Sack of Dog Shit. #Microcephaly #Musktard #FamilyResemblance #FuckMusk #Neanderthal

Travelers: Beware of Oropouche virus. Is it the next Zika? Heading south for the winter? Oropouche virus, a new infectious disease, has been reported in travelers from Canada and the United States who visited Bolivia, Brazil, Peru, and Cuba. An article…

Beware of #Oropouche #virus ...

| #travel | #Zika | #pathogens | #dengue | #miscarriage | #microcephaly | By the Canadian Medical Association Journal via @sciencex.bsky.social

Newborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical tr...

Via @thelancetinfdis.bsky.social:
“We detected #oropouche IgM in 6/68 newborns with #microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain.” We need to monitor these 🇧🇷 findings elsewhere. #idsky #pedsid
www.thelancet.com/journals/lan...

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening Nature Communications - Human brain organoids are plagued by heterogeneity and poor reproducibility, critical parameters for reliable disease modeling and drug testing. Here, the authors report on...

New paper out from our @for5547.bsky.social PIs Jay Gopalakrishnan and @nathaliejuya.bsky.social on human #brain #organoids modeling #microcephaly
www.nature.com/articles/s41...

Newborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical tr...

🪰"Newborns with #microcephaly in #Brazil and potential vertical transmission of #Oropouche #virus: a case series" by Fernanda Eduarda das Neves Martins et al. from Evandro Chagas Institute in The Lancet Infectious Diseases
www.thelancet.com/journals/lan...

Discovery "could lead to ways of generating Zika virus vaccines" - new insights into #microcephaly from study:

is.gd/UxgqN9

Goo.gl is sunsetting

DONSON maintains genome stability during DNA replication; mutated in #microcephaly. @NatureGenet https://goo.gl/sWx1CZ

Prevalence and Clinical Attributes of Congenital Microcephaly — New York, 2013–2015 | MMWR CDC report establishes prevalence of severe congenital microcephaly.

Infection Control - #ZikaVirus - Prevalence & Clinical Attributes of Congenital #Microcephaly in New York, 2013-2015

cdc.gov/mmwr/volumes/6…

Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy — Colombia, January–November 2016 | MMWR Microcephaly increases fourfold in Colombia over previous year.

Infection Control - #Colombia - #Microcephaly Associated w/ #ZikaVirus Infection During Pregnancy:

cdc.gov/mmwr/volumes/6…

The Zika Virus Can Cause More Birth Defects Beyond Microcephaly Even if babies were born with normally-sized heads, they may still suffer lifelong effects from Zika exposure in the womb.

Infection Control - Parental - #ZikaVirus Can Cause More Birth Defects Beyond #Microcephaly, Study Shows:

huffingtonpost.com/entry/the-zika…

New doubts on Zika as cause of microcephaly Brazil's microcephaly epidemic continues to pose a mystery -- if Zika is the culprit, why are there no similar epidemics in other countries also hit hard by the virus? In Brazil, the microcephaly rate soared with more than 1,500 confirmed cases. But in Colombia, a recent study of nearly 12,000 pregnant women infected with Zika found zero microcephaly cases. If Zika is to blame for microcephaly, where are the missing cases?

Infection Control - New doubts on #ZikaVirus as the cause of #microcephaly:

sciencedaily.com/releases/2016/…