Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing - Nature Neuroscience Dissecting the adaptive exercise response of the neurogenic stem-cell niche in the dentate gyrus by single-nucleus RNA sequencing reveals the molecular mediators that underlie exercise’s protective ef...

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing

#neuroprotection #neurodegenration #oligodendroglia #neurogenesis #microglia #astrocyte #myelination #exercise #singlecell #transcriptomics 🧪

doi.org/10.1038/s415...

Wednesday breakfast seminar.

Good morning #ASMS2025! 🌞. Don't miss Biognosys' breakfast showcasing real-world applications of #Proteoomic.
Come to room 343-344 for some exciting results on #Immunopeptidomics and circulatory #Biomarkers to detect early detection of #Neurodegenration.

The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy

www.nature.com/articles/s41... or how Apoptosis control by BCL2-family targeting can tackle a plethora of human diseases! A review coordinated by Meike Vogler togetherwith international consortium! 🙏 for opportunity to contribute explaining #calcium #signaling & implications for #neurodegenration!

A microglia clonal inflammatory disorder in Alzheimer’s disease A subset of Alzheimer disease patients carry mutant microglia somatic clones which promote neuro-inflammation.

A microglia clonal inflammatory disorder in Alzheimer's disease.

#microglia #neurodegenration #somatic_mutation #AD

doi.org/10.7554/elif...

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions - Nature Communications The Human Microglia Atlas includes 91,716 brain immune cells covering six neurologic pathologies. It characterizes the signatures of nine populations and describes the expansion of GPNMB-high microgli...

Human microglia atlas unmasks subtype-specific roles of microglia in neurodegenerative disorders.

#single-cell #single-nucleus #omics #neurodegenration #microglia

doi.org/10.1038/s414...

🇬🇧 #infectnetIV Recap: Ina Maja Vorberg from #DZNE about the connections between #ageing, #Alzheimer's, #prions and viral #infections in the #brain. The activation of human endogenous #retroviruses plays an important role. #HERV #Tau #neurodegenration 🧠💜