Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain A fully characterised organ-on-a-chip model of the human coronary artery with endothelial and smooth muscle cells, plus circulating immune cells, created on the Emulate platform. The model successful...

Using @emulatebio.bsky.social’s organ-on-chip platform, researchers at @qmulsems.bsky.social created a human coronary artery organ-chip model of vascular inflammation.

onlinelibrary.wiley.com/doi/10.1002/...

#CardioSky #OrganChip #OrganOnChip #Bioengineering 🧪

Also out in @labonachip.rsc.org!

“Breakthrough Technologies and Applications in Organ-On-a-Chip," features some of the most innovative and groundbreaking #OrganChip technology and its applications.

Check out the full collection here: pubs.rsc.org/en/journals/...

#MPS #OrganonaChip #OrganonChip

Organ-on-a-chip tests elderly people immune reaction to cancer vaccines Research from the US shows that a new lymph-node-on-a-chip can replicate age-dependent immune responses to cancer vaccines, providing a more accurate testing platform.

Research from the Terasaki Institute shows that a new lymph-node-on-a-chip can replicate age-dependent #immune responses to #cancer vaccines, providing a more accurate #testing platform. www.eara.eu/post/organ-o... #ageing #therapy #vaccine #research #scicomm #USA #researchnews #organchip #NAM

📄 In a recent #Microscopy #AppNote, we validate the AIM Biotech idenTx series of #OrganOnChip plates for a 3D #Angiogenesis assay of drug efficacy.

🔬 High-resolution 3D imaging was performed using the Nikon AX #Confocal #Microscope system.

🔗 Learn more: bit.ly/4o1Cr9j

#Imaging #MPS #OrganChip

Human Organ-On-A-Chip: Technologies Offer Benefits Over Animal Testing but Challenges Limit Wider Adoption We examined "human organ-on-a-chip" technologies—laboratory tools that use human cells to mimic organs, model diseases, and more. This new technology...

In May, GAO published a report on the state of #OrganChip technology, its benefits over experiments on animals, and the steps needed to advance the field. 🧪

Expand this 🧵 for a brief summary + more thoughts 👇 www.gao.gov/products/gao...

#organonachip #microfluidics

🔬 In this #Microscopy #AppNote we evaluate our AX / AX R #Confocal #Microscope system for imaging a kidney proximal tubule #OrganChip model, demonstrating the sensitivity needed to clearly resolve primary cilia in 3D.

🔗 Click here to view the app note: bit.ly/45pJT74

Frontiers | Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier Over the past decade, organ-on-chip technology (microphysiological systems or tissue chips) has reshaped in-vitro physiological and pathological modeling and...

In this review, Nina Truong & colleagues from @utmbhealth.bsky.social highlight #organchip systems for reproductive & pregnancy-associated biology. The authors emphasize that maximizing throughput will help them realize their full translational potential.

www.frontiersin.org/journals/bio...

Scientific Director, Linda G. Griffith, PhD • The MIT Center for Gynepathology Research

Dr. Linda Griffith and her team at @mit.edu are leading the way in humanizing drug development for #endometriosis and #adenomyosis, integrating #organchip technology with systems biology & systems immunology.

Explore her work:
cgr.mit.edu/people/linda...

Our new #organoid #organchip #coculture review. Congrats @kamilmoskal.bsky.social, Yeseul Lee, Luisa Siegert, Nimisha Khurana from @emil-dkfz.bsky.social @dkfz.bsky.social!
Cool experience connecting the dots between in organotypic models and microbiome with @hansclevers.bsky.social and Eran Elinav

Only a few days remaining to apply for a #PhD with me at the #EPSRC funded QMUL #CDT. The project involves working on the host-microbe interactions in the human mouth using novel #3D #organotypics / #organchip models #metabolomics

Deadline is Monday, January 6th, 9am.

Engineers apply new tech to model deadly brain tumors Researchers are using 3D bioprinting to create artificial blood vessels that can be used to test new custom-tailored drugs and study why brain tumors are so resilient.

A team at #UofCincy & #UNCChapelHill is speeding up the fabrication of human #microphysiologicalsystems using #3Dbioprinting! Read more about how this system could lead to breakthroughs for understanding & treating #glioblastoma.
www.uc.edu/news/article...
#mps #organchip

Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications Glioblastoma, an aggressive brain cancer, possesses treatment challenges due to its complexity and the blood-brain barrier. Organ-on-a-chip models are emerging as valuable tools for investigating GBM....

Check out this review on organ-on-a-chip models for #glioblastoma research, drug development, & personalized medicine. By Surjendy Maity, & collaborators at @terasakiinstitute.bsky.social, @dukemedschool.bsky.social, et al.
onlinelibrary.wiley.com/doi/10.1002/...
#organchip #drugdevelopment