Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma

Researchers map #SystemicImmunity in #POAG via #SingleCellRNASeq of #PBMCs, revealing increased CD4+ T cells, impaired cytolytic potential, and a dual proinflammatory/neuroprotective landscape, linking immune dysregulation to #retinal health.

#OpenAccess #STTT: doi.org/10.1038/s413...

Ever wondered why some #MS patients thrive on #Ocrelizumab while others don’t? 👀🧬”
Baseline #TNF levels in #PBMCs quietly forecast treatment failure!📉 @mdpiopenaccess.bsky.social #MSResearch #Ocrelizumab #PrecisionMedicine
Dive in + share 👇
www.mdpi.com/1422-0067/26...

“Ever wondered why some #MS patients thrive on #Ocrelizumab while others don’t? 👀🧬”
Baseline #TNF levels in #PBMCs quietly forecast treatment failure!📉 @mdpiopenaccess.bsky.social #MSResearch #Ocrelizumab #PrecisionMedicine
Dive in + share 👇
www.mdpi.com/1422-0067/26...

This study maps the immune landscape of #POAG using #SingleCellRNASequencing of 1.4 million #PBMCs, revealing immune remodeling with increased CD4+ & myeloid cells, and a disrupted balance between inflammatory & #NeuroprotectiveSignaling.

#OpenAccess #STTT: doi.org/10.1038/s413...

www.nature.com/articles/s41...

#LOY #CancerGenomics #Immunology #CancerResearch #PrecisionOncology #Epigenetics #TumorMicroenvironment #MenHealth #Oncology #PanCancer #Tcells #PBMCs #Genetics

Frontiers | Hazards of lunar surface exploration: determining the immunogenicity/allergenicity of lunar dust Although infrequent, there have been Apollo program reports of lunar dust exposure leading to notable upper respiratory symptoms in select crewmembers. Possi...

#astronauts reported increasing upper respiratory tract symptoms upon repeated exposure to #moon dust indicative of #allergy
it would be so interesting to repeat this with #PBMCs from afflicted #ISS crew
#spaceexploration
#medsky
#immunosky
🧪
www.frontiersin.org/journals/imm...

Starting now #ADPD2025 #BrainGutInteractions session in Hall F1 that will include a talk by our #TanseyLab3.0 most recent PhD graduate @mackenziebolen presenting her #spatialomics studies in #colonicbiopsies & #PBMCs from #IBD & #Parkinsons pts