This study identifies four molecular subtypes within HR+/HER2+ #BreastCancer and shows how their distinct biology guides tailored therapies, from intensified #antiHER2 regimens to ER–HER2 targeting, ADCs, #immunotherapy, and #PI3Kinhibitors.

#OpenAccess #STTT: doi.org/10.1038/s413...

How soy and gut microbes alter cancer treatment results Researchers have discovered that plant-derived phytochemicals and their gut microbiome metabolites control the effectiveness of PI3K inhibitors in cancer therapy. The study reveals that dietary compon...

How soy and gut microbes alter cancer treatment results www.news-medical.net/news/2025060... #cancer #microbiome #phytochemicals #PI3Kinhibitors #drugmetabolism #soy #precisionmedicine #oncology #dieta #cancer @cellpress.bsky.social

The contex specific PI3k signalling tune

#MedSky🧪#IDSky #ImmunoSky #MolecularBiology Recap : Although some #PI3Kinhibitors have been approved for clinical use, most of these compounds have failed to meet the initial high expectations and their utility in #cancertreatment is limited by systemic toxicity and/or tumor drug resistance .