Postdoctoral Research Assistant | MRC PPU We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...

Join us! Postdoctoral Research Assistant position available in the Muqit lab www.ppu.mrc.ac.uk/careers/recr... #neurobiology #CRISPR #PINK1 #Parkinsons

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration
@mrcppu.bsky.social

www.science.org/doi/10.1126/...

Advances in mitophagy initiation mechanisms

🤣🤣 here you go! Sorry to keep you waiting 😶‍🌫️

Highlights:
-A review on the role of #mitophagy in 🫀 disease and one on the molecular steps of mitophagy initiation,
- the DNA damage response protein ATM and #PINK1 directly interact 🩷💥
-AMPK and Parkin regulate antigen presentation

Undiscovered cause of Parkinson’s found for first time by scientists in huge breakthrough that could pave the way for new treatments for the neurodegenerative disease #ParkinsonsDisease #PINK1 #HallInstitute #Parkinsons
Rebecca Whittaker Reporting
www.independent.co.uk/news/health/...

Parkinson, la speranza si accende: svelata la struttura della proteina Pink1 Per la prima volta, gli scienziati hanno esaminato in dettaglio la struttura della proteina Pink1, associata allo sviluppo del morbo di Parkinson. Grazie

Parkinson, la speranza si accende: svelata la struttura della proteina Pink1
#Parkinson #proteina #Pink1 #medicina #salute
guruhitech.com/parkinson-la...

Structure of human PINK1 at a mitochondrial TOM-VDAC array Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson’s Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determi...

Big breakthrough in #Parkinsons research could lead to new treatments. Study in @science.org visualizes #PINK1 for the 1st time and shows how it binds to mitochondria. Mutated PINK1 disrupts mitophagy which leads to cell death. www.science.org/doi/10.1126/...

Scientists make ‘life-changing’ discovery for people with Parkinson’s Experts make breakthrough that could pave way for new treatments for neurodegenerative disease

👇🇦🇺"Scientists make ‘life-changing’ discovery over protein linked with Parkinson’s" #ParkinsonsDisease
#PINK1 #ParkinsonsProteinDiscovered #HallInstitute

Scientists solve decades-long Parkinson’s mystery WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.

World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.

www.wehi.edu.au/news/scienti...

Transmembrane Parkinson’s disease mutation of PINK1 leads to altered mitochondrial anchoring Parkinson’s disease is a devastating neurodegenerative disease resulting from the death of dopaminergic neurons in the substantia nigra pars compacta …

Proud of my recent graduate Dr. Raelynn Brassard's work on understanding mutations associated with inherited forms of Parkinsonism, just out in J Biol Chem! #PINK1 #biochemistry
www.sciencedirect.com/science/arti...

JCI - PINK1 is a target of T cell responses in Parkinson’s disease

An #autoimmune response involving #PINK1 may help explain why #Parkinsons is much more common in men. Study in @jclinical-invest.bsky.social shows men with PD had a 6-fold increase in PINK1-specific T cells; women with PD showed only a 0.7 increase. www.jci.org/articles/vie...

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. We previously reported that the anthelmintic drug flubendazole induced autophagy and apopto...

www.ncbi.nlm.nih.gov/pmc/articles...

"Meanwhile, flubendazole increased dynamin-related protein ( #DRP1) expression, leading to the accumulation of PTEN induced putative kinase 1 ( #PINK1) and subsequent mitochondrial translocation of Parkin, thereby promoting excessive mitophagy."