Collage of Pedro Pascal matched to ME/LC research infographics with research titles. “Girls be like ‘I needed that’ and it’s just Pedro Pascal”
Sometimes you just need some #PedroPascal in your #LomgCovid #MECFS research.
More #PedroPascalPapers coming soon!
Pedro Pascal enticing you as ME research Validation of the Severity of Myalgic Encephalomyelitis by Other Measures than History Healthcare, 2020 This study confirms well defined differences in validated SF-36 physical activity questionnaire, daily steps, & cardiopulmonary exercise testing among the International Consensus Criteria (ICC) ME diagnosis severity categories: Mild- 50% reduction in pre-illness activity, Moderate-mostly housebound, Severe-mostly bedbound, Very severe-bedbound require assistance with physical function
Pedro pascal dashing as ME research Abnormal T-Cell Activation And Cytotoxic T-Cell Frequency Discriminates Symptom Severity In ME UK Biobank Pre-Print, 2025 Clear differences exist in immune cells in people with mild/moderate vs severe ME/CFS & support stratification in diagnostic tools, management & treatment. Mild/Mod ME exhibited stronger correlation between cytotoxic marker expression & senescent T cells and DN MAITs suggesting frequent antigen exposure likely related to persistent infection or reactivation. Severe ME had ongoing uncontrolled pro-inflammatory immune system activation with more activated T cells, higher cell activation & pro-inflammatory cytokine production in response to stimulation.
Pedro Pascal having fun as ME research Assessing Functional Capacity in ME/CFS J Clin Med, 2024 Categories • Basic Function/ Personal Hygiene • Walking/ Movement • Being Upright • Activities in the Home • Communication • Activities outside the Home • Reactions to Light & Sound • Concentration Scores O. Cannot do this 1. Capacity severely limited for at least 3 days 2. Can do little else same day +2 days after 3. Can do little else same day 4. Must limit activity same day 5. Rarely affects other activities 6. Unproblematic
Pedro Pascal melancholy as ME Research Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis PLOS, 2015 The health-related quality of life of ME/CFS is the lowest of all the compared conditions (including multiple sclerosis, lung cancer, renal failure, stroke etc) and significantly lower than the population mean. This analysis confirms that the poor health related quality of life of ME/CFS is distinctly different from & not a proxy of other included conditions.
Some #PedroPascalPapers to brighten up #SevereME week
It’s what inspired the #PedroPascalPapers!
@verhac.bsky.social -sorry last one didn’t work. Check this one out for more #PedroPascalPapers
Some more Pedro Pascal as ME & LC research to get you through the week
#PedroPascalPapers #MillionsMissing
Who’s your daddy?
(Sound on)
🫧🫧 exactly. Speaking my language ❤️🌺
And that was absolutely my intention with #PedroPascalPapers dress it up to make more palatable and appealing
Given the heavy topic I appreciated the sense of #PedroPascalPapers humor, having/had MECFS friends, and was curious what the story was.
All the best, and I'm crossing the fingers for a happy "Leave only bubbles, take only memories" in the future!
I have some of them posted if you search #PedroPascalPapers. I didn’t finish posting them all on BS but almost all the links are in my MedEd highlights on instagram @mayabee24
🤗
#PedroPascalPapers ?!
😆🥹😍👏
I am already a huge fan.
#MECFS
#LongCovid
A little bit of #PedroPascalPapers to get you through the week.
Making #MECFS & #LongCovid Research irresistible
Love the radiant @mayalongcovid.bsky.social matching the #PedroPascalPapers here too!
Pedro Pascal matched to ME research The future is a policy choice: Addressing Infection-Associated Chronic Conditions Crunch ME, 2025 Medicine has long had a blind spot on Infection-Associated Chronic Conditions (IACC), which include: Long Covid, ME/CFS, POTS, MCAS, Fibromyalgia, & Chronic Lyme Disease. ME/CFS has a greater disease burden than MS & Parkinson's combined, while Long Covid disease burden is comparable to diabetes. Despite the high severity and disease burden, Long Covid & ME/CFS are deeply underfunded in proportion to their Disability-Adjusted Life Years (DALY).
Day 11 #PedroPascalPapers
#MEAwarenessMonth
“The future is a policy choice”
Sending out a #DisabilitySOS for the #MillionsMissing @meactnet.bsky.social
@crunchme.bsky.social
Pedro Pascal matched to ME research WASF3 disrupt mitochondrial respiration & may mediate exercise intolerance in ME/CFS PNAS, 2024 This study shows that endoplamic reticulum (ER) stress-induced WASF3 protein disrupts mitochondria respiration, leading to decreased oxygen consumption & exercise endurance. Alleviating ER stress decreases WASF3 and restores mitochondrial function, indicating that WASF3 can impair skeletal muscle bioenergetics and may be targetable for treating fatigue symptoms.
Day 10 #PedroPascalPapers
for #MEAwarenessMonth
Another great study on MECFS with targetable treatments 😍
Research this good looking how can you resist?
#GreatestMEdicalScandal
Pedro Pascal as ME research infographics Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis Chest, 2021 During exercise, ME/CFS patients averaged lower right atrial pressures (RAP) and peak oxygen uptake (VO2) compared with control subjects. Two types of neurovascular dysregulation contribute to ME/CFS exertional intolerance: Decreased cardiac output from impaired venous return (blood return to heart) & impaired peripheral oxygen extraction. Small fiber pathology may cause neuropathic dysregulation by shunting oxygenated blood from capillary beds and reducing cardiac return.
Another banger of a study
Day 9 #PedroPascalPapers for #MEAwarenessMonth
#MECFS #GreatestMEdicalScandal #MedEd
journal.chestnet.org/article/S001...
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord Immunol Resp, 2025 Mouse model of potential ME Post Exertional Malaise mechanism. The inhibition of ATG13 (autophagy-related protein) activation impairs autophagy (remove/recycle damaged cells), increases inflammation and demyelination (damage to protective cover of nerves) in muscle serving nerves & spinal cord.
Day 8 #PedroPascalPapers #MEAwarenessMonth
Mouse model of ME/#PEM
#MillionsMissing #GreatestMEdicalScandal
pubmed.ncbi.nlm.nih.gov/39777574/
Pedro Pascal as ME infographics Assessing Functional Capacity in ME/CFS J Clin Med, 2024 Categories: • Basic Function/ Personal Hygiene • Walking/ Movement • Being Upright • Activities in the Home • Communication • Activities outside the Home • Reactions to Light & Sound • Concentration Scores: O. Cannot do this 1. Capacity severely limited for at least 3 days 2. Can do little else same day +2 days after 3. Can do little else same day 4. Must limit activity same day 5. Rarely affects other activities 6. Unproblematic
Day 7 #PedroPascalPapers for #MEAwarenessMonth
FUNCAP is the best assessment tool we have at quantifying PEM imo. A *Monthly* average of the consequences of exertion
Now available as an app (search FUNCAP)
#PEM #MECFS #GreatestMEdicalScandal
www.funcap.no
Pedro Pascal as ME research infographics Single-cell transcriptomics of the immune system in ME/CFS at baseline and symptom provocation Cell, 2024 The ME/CFS immune system is profiled by scRNA-seq at baseline and after provocation. Monocyte dysregulation is prominent and correlates with disease severity. Platelets are dysregulated, but resolves after provocation.
Day 6 #PedroPascalPapers #MEAwarenessMonth
#MECFS #PEM
www.sciencedirect.com/science/arti...
Pedro Pascal as ME research infographics Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in ME/CFS Int J. Mol 2023 Significant differences in the urine metabolome suggest that the metabolism of healthy sedentary controls undergo major changes that allow them to recover from exertion, while ME/CFS patients do not. These pathways are involved in, but not limited to, energy metabolism. This indicates that ME/CFS patients have a general metabolic dysregulation that is part of exercise intolerance and PEM.
#PedroPascalPapers Day 5 of #MEAwarenessMonth
#MillionsMissing #MECFS #GreatestMEdicalScandal
pmc.ncbi.nlm.nih.gov/articles/PMC...
Pedro Pascal as ME LC research infographics Muscle Abnormalities Worsen After Post Exertional Malaise in Long Covid Nature, 2024 Systemic metabolic disturbances, severe exercise-induced myopathy (including necrosis) and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after post-exertional malaise
#PedroPascalPapers Day 4 #MEAwarenessMonth
@patientled.bsky.social
#GreatestMEdicalScandal
Pedro Pascal matched to ME research infographics Recovery from Exercise in Persons with Myalgic Encephalomyelitis Medicina, 2023 2-Day CPET (cardiopulmonary exercise test): 1st CPET measures baseline energy-producing capacity & provokes PEM. 2nd CPET assesses the ability to reproduce the first. ME subjects can't reproduce CPET1. Sedentary controls only needed ~2 days to recover. ME/CFS subjects took an average of two weeks to recover from a 2-day CPET, 10% took more than 3 weeks to recover, 1 hadn't recovered after a year. "Our data suggest that graded exercise therapy almost certainly would cause harm"
Day 3 #PedroPascalPapers
#MEAwarenessMonth #MillionsMissing #PostExertionalMalaise #PEM #GreatestMEdicalScandal #PedroPascal
pubmed.ncbi.nlm.nih.gov/36984572/#:~....
Pedro Pascal as ME research infographics Neural consequences of Post-Exertional Malaise in Myalgic Encephalomyelitis Brain Behav Immol., 2017 This study provides objective evidence that PEM affects cognition, having widespread effects on brain regions associated with attention, working memory & executive function. ME/CFS patients responded opposite to controls post-exercise: greater brain activity (suggests more neural resources needed to complete tasks), reduced cognitive performance (greater errors) & increased symptoms. These results emphasize the strong negative impact that PEM can have on the central nervous system.
#PedroPascalPapers Day 2
#MEAwarenessMonth
#MillionsMissing #PostExertionalMalaise #MEdEd #TeachMETreatME #GreatestMEdicalScandal
Pedro Pascal as ME infographics Diagnosis & Management of ME/CFS Mayo Proceedings, 2023 Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic neurologic disease often preceded by infection. The pathognomonic symptom of ME/CFS is post-exertional malaise (PEM): a flare in symptoms or the appearance of new symptoms after sensory overload or physical/cognitive exertion, often delayed 12-48 hours. Symptoms may include: sensory sensitivity, autonomic dysfunction, cognitive impairment, pain, immune dysregulation, energy/metabolism problems
Kicking off #MEAwarenessMonth with Daily #PedroPascalPapers
#MillionsMissing #DisabilitySOS #MEdEd
www.mayoclinicproceedings.org/article/s002...
Pedro Pascal matched to ME/LongCovid research infographic The future is a policy choice: Addressing Infection-Associated Chronic Conditions Crunch ME, 2025 Medicine has long had a blind spot on Infection-Associated Chronic Conditions (IACC), which include: Long Covid, ME/CFS, POTS, MCAS, Fibromyalgia, & Chronic Lyme Disease. ME/CFS has a greater disease burden than MS & Parkinson's combined, while Long Covid disease burden is comparable to diabetes. Despite the high severity and disease burden, Long Covid & ME/CFS are deeply underfunded in proportion to their Disability-Adjusted Life Years (DALY).
#PedroPascalPapers
#LongCovidAwarenessDay
@crunchme.bsky.social
Pedro Pascal matched to ME/LongCovid research infographic Long Covid Now Looks Like a Neurological Disease Scientific American, 2023 Covid protein found in neurons & astrocytes up to 3 months after initial infection in those with neuropsychiatric symptoms. Autopsies have found Covid RNA in the brain up to 8 months after infection. Those with cognitive problems have immune-related abnormalities in their cerebrospinal fluid & higher amounts of immune cells in the brain that should not be there, causing inflammation. "(Long Covid) is not a psychological or psychosomatic disorder; this is a neuroimmune disorder"
Pedro Pascal matched to ME/LongCovid research infographic Current update on the neurological manifestations of long COVID PubMedID: 39850323, 2024 Neuroinflammation: elevated levels of pro-inflammatory cytokines & autoantibodies →chronic inflammation in central & peripheral nervous systems. Latent virus reactivation exacerbates & viral reservoirs may perpetuate inflammation. Endothelial dysfunction damages blood brain barrier. Hypometabolism likely due to mitochondrial dysfunction & oxidative stress are found in high ACE2 areas such as brainstem, hippocampus, olfactory bulb. Autonomic dysfunction is possibly due to damage to the brainstem & vagus nerve. Genetic susceptibility
Pedro Pascal matched to ME/LongCovid research infographic Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 Cell, 2024 The accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients was observed, persisting long after viral clearance. Biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients. Proteomic analysis of human skull, meninges, and brain samples revealed dysregulated inflammatory pathways and neurodegeneration-associated changes.
Pedro Pascal matched to ME/LongCovid research infographic Microglia dysfunction, neurovascular inflammation & focal neuropathologies are linked to... systemic inflammation in COVID Nature Neuroscience, 2025 Microglial dysfunction, mitochondrial failure & cell death occurs at sites of Covid-associated vascular inflammation. These pathologies are found in several areas of the brain, but more severe in the medulla, where key autonomic centers are localized. Covid induced inflammation may lead to gliovascular failure in the brain, which could be a common contributor to COVID-19-related neuropathologies
#PedroPascalPapers
Pedro Pascal as Neurological Manifestations of #LongCovid #LongCovidAwarenessDay
More #PedroPascalPapers for #LongCovidAwarenessDay (a day late)
#MECFS #LongCovid #PEM #PostExertionalMalaise #OrthostaticIntolerance #POTS #IACC #GreatestMEdicalScandal #JohnVsJonVsME #PedroPascal #MedEd #5YearsLongCovid #FundThePlan #WearAMask #LongCovidResearch #LongCovidSOS #MillionsMissing
