Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome.

Beautiful cover art too!

@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social

💡 Online now - the Spotlight "Cryptic phosphorylation sites provide new structural and functional insights into the human phosphoproteome" from Jesse Rinehart.

#ProteinPhosphorylation #Phosphoproteome #CrypticPhosphorylation

Read it here 👉 authors.elsevier.com/a/1mTsH3S6Gf...

What drives insulin resistance? Proteomics reveals key pathways in human skeletal muscle Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes therapies based on molecular profiles.

What drives insulin resistance? Proteomics reveals key pathways in human skeletal muscle www.news-medical.net/news/2025053... #InsulinResistance #Type2Diabetes #Proteomics #Metabolism #Phosphoproteome #Biomarkers #PersonalizedMedicine #Diabetes @cellpress.bsky.social

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions This study presents a comprehensive atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions using advanced proteomics and isotope labeling. It reveals tissue-specific pr...

#Turnover atlas of #proteome and #phosphoproteome across #mouse #tissues and #brain regions: Cell www.cell.com/cell/fulltex...