Are we #prodrugs ? Or are we #antidrugs ? Hard to tell these days.....

Interesting talk by Petra Heffeter at the #MCBIM mini-symposium at @leidenscience.bsky.social.

She talked about hypoxia-activated and albumin-bound, inorganic #prodrugs against #cancer.

www.sciencedirect.com/science/arti...
#ChemSky #ChemBio #DrugDiscovery

Are you thinking of pursuing a #prodrug strategy for your drug discovery programme? If so, get in touch with #Domainex to find out how we can help or take a look at our new webpage for more information:
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs

Job Vacancy at the University of Sunderland: Senior Research Assistant About the University of Sunderland The University of Sunderland offers life-changing opportunities for 27,500 students across its campuses in Sunderland, London, Hong Kong, and through global partners...

Opportunity for synthetic/medicinal chemist: #prodrugs for the treatment of rare kidney disease at University of Sunderland (UK) ref: 0163-25 | closing: 08-Jun-2025 | starting 01-Sep-2025 | duration: 12 months #MedChem #SynChem #UKChemJobs #chemsky 🧪
jobs.sunderland.ac.uk/vacancy.aspx...

Le jeudi 22 mai 2025 : Nous avons le plaisir d'accueillir Dr. Benoit Guichard postdoctorant à l'ICOA. A 11h à la Salle des séminaires de l'ICOA, le Dr. Benoit GUICHARD donnera une conférence dont le sujet est : Development of salicylic #prodrugs and Nitrogen Isotopic Exchange methodologies.

Special Issue: Polymer–Drug Conjugate Materials

📝It was an exciting experience to handle this special issue on #polymer-drug conjugates/polymer #prodrugs for Chemistry of Materials @pubs.acs.org ! #chemsky

📰Editorial: pubs.acs.org/doi/10.1021/...

A few words about the contents of this Special issue 🧶

Albumin-targeted oxaliplatin(IV) prodrugs bearing STING agonists The anticancer platinum complex oxaliplatin exerts its activity through DNA damage and immune-stimulatory mechanisms, but is associated with adverse treatment side effects. Platinum(iv) complexes repr...

📢Don't miss the #OpenAccess #research by Christian R. Kowol et al. @univie.ac.at

👉#Albumin-targeted oxaliplatin(iv) #prodrugs bearing STING #agonists

#Chemsky #ICF_research #Inorganic #anticancer
doi.org/10.1039/D5QI...

Researchers at Children's Hospital Uncover New Antimalarial Treatment Strategy Using Prodrugs Children's Hospital of Philadelphia researchers unveil a novel strategy using prodrugs to combat malaria by leveraging a human enzyme for increased efficacy.

Researchers at Children's Hospital Uncover New Antimalarial Treatment Strategy Using Prodrugs #United_States #Philadelphia #Children's_Hospital #antimalarial #prodrugs

Overlay of crystal structures of ABH (green, PDB:1D3V), proline (cyan, PDB: 8RGU) and compound 9 (yellow, PDB: 8RFA) bound to Arg2.

In the latest edition of our "Medicinal Chemistry in Review" blog series, we have focused on a recent paper from AstraZeneca describing the development of actively transported Arginase inhibitor #prodrugs.
lnkd.in/e58RmY82
We hope you enjoy it.
#DrugDiscovery #MedChem

Happy to welcome Julia Ryll & Aya Alfarem to our research team!!🎉🎉 Julia joined us as a PhD student and is developing #anticancer #prodrugs and #PROTACs, while Aya, our new Master's student, is working on #electrochemical #CHfunctionalization! We’re thrilled to have them on board! #Welcome #ChemSky

Exploring the Structure–Activity Relationships of Albumin-Targeted Picoplatin-Based Platinum(IV) Prodrugs | Inorganic Chemistry pubs.acs.org/doi/10.1021/... @KowolLab Heffeter, and co-workers @InorgChem #platinum #IV #albumin #picoplatin #GSH #maleimide #prodrugs #anticancer