RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/40/5-6/396.abstract
@zz-zhang.bsky.social Duke University School of Medicine
#retrotransposon #Drosophila
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ genesdev.cshlp.org/content/early/2026/01/22...
#retrotransposon #Drosophila #genomestability
💥👁 #Exciting #research #alert
#Macrophage #retrotransposon expression is associated with #lupus
#genes & #Immunity @springernature.com
www.nature.com/articles/s41...
A phylogenetic estimate of canine retrotransposition rates based on genome assembly comparisons. #CanineGenomes #Retrotransposon #LINE1 #SINE #GenomeAssembly #GenomeEvolution #Genomics @biorxivpreprint.bsky.social 🧪🧬 🖥️
www.biorxiv.org/content/10.1...
New Study Uncovers the Genetic Mechanism Behind Viruses and Major Diseases #United_States #New_York #NYU_Langone #LINE-1 #Retrotransposon
Copia and Arc interactions at the NMJ. In the presynaptic neurons, Copia and Arc RNAs antagonize each other’s expression at the transcriptional level. Presynaptic Copia and Arc RNAs are encapsulated by their own RNA-encoded Gag proteins to form virus-like capsids, which are subsequently released by the presynaptic neurons into the EVs to cross the NMJ. The capsids of Copia and Arc in EVs are then engulfed by the postsynaptic cells, where the virus-like capsids are disassembled to release the embedded RNAs and Gag proteins. The balance of released Copia and Arc RNA and Gag proteins impacts the rate of synapse formation.
Yung-Heng Chang & @joshdubnau.bsky.social explore a @plosbiology.org study revealing that the #retrotransposon gag protein of Copia forms virus-like capsids that transfer its own RNA across the fly neuromuscular junction to regulate #synapse formation 🧪 Paper: plos.io/3X71IDa Primer: plos.io/4i6rzmC
Copia and Arc interactions at the NMJ. In the presynaptic neurons, Copia and Arc RNAs antagonize each other’s expression at the transcriptional level. Presynaptic Copia and Arc RNAs are encapsulated by their own RNA-encoded Gag proteins to form virus-like capsids, which are subsequently released by the presynaptic neurons into the EVs to cross the NMJ. The capsids of Copia and Arc in EVs are then engulfed by the postsynaptic cells, where the virus-like capsids are disassembled to release the embedded RNAs and Gag proteins. The balance of released Copia and Arc RNA and Gag proteins impacts the rate of synapse formation.
Yung-Heng Chang & @joshdubnau.bsky.social explore a @plosbiology.org study revealing that the #retrotransposon gag protein of Copia forms virus-like capsids that transfer its own RNA across the fly neuromuscular junction to regulate #synapse formation 🧪 Paper: plos.io/3X71IDa Primer: plos.io/4i6rzmC
Copia and Arc interactions at the NMJ. In the presynaptic neurons, Copia and Arc RNAs antagonize each other’s expression at the transcriptional level. Presynaptic Copia and Arc RNAs are encapsulated by their own RNA-encoded Gag proteins to form virus-like capsids, which are subsequently released by the presynaptic neurons into the EVs to cross the NMJ. The capsids of Copia and Arc in EVs are then engulfed by the postsynaptic cells, where the virus-like capsids are disassembled to release the embedded RNAs and Gag proteins. The balance of released Copia and Arc RNA and Gag proteins impacts the rate of synapse formation.
Yung-Heng Chang & @joshdubnau.bsky.social explore a @plosbiology.org study revealing that the #retrotransposon gag protein of Copia forms virus-like capsids that transfer its own RNA across the fly neuromuscular junction to regulate #synapse formation 🧪 Paper: plos.io/3X71IDa Primer: plos.io/4i6rzmC
The role of retrotransposable elements in aging and age associated diseases
pmc.ncbi.nlm.nih.gov/articles/PMC... #aging #longevity #disease #cancer #retrotransposon
LINE-1 retrotransposons are reactivated in Alzheimer’s, triggering DNA damage and driving tau pathology. New research highlights this vicious cycle as a main mechanism of this disease as well as a potential therapeutic target.
#AlzheimersResearch #Neuroscience #Genomics #retrotransposon #Alzheimer
Retrotransposon expression is unregulated by aging and suppressed during regeneration of the limb in the axoloti #Retrotransposon #aging #regeneration #longevity
www.biorxiv.org/content/10.1...
Hi! 👋 I'm new here 👋
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
Otsikko: Retrotransposonit märehtijöiden perimässä A DNA sequence of a SINE (short interspersed nuclear element) showing the relative frequences of each base in each position
Haluaako joku nähdä mun gradun 😊: drive.google.com/file/d/1uqoG...
Se on juurikin näistä retrotransposoneista, jotka täyttävät meidänkin DNA:stamme melkein puolet (sic!)
#retrotransposon #progradu
