Allosteric modulation of ataxin-3 aggregation and potential therapeutic strategies for Machado-Joseph disease. The power of teamwork to tackle complex biological questions!

👉www.biorxiv.org/content/10.1101/2025.01....

#Neurodegeneration #SCA3 #Allostery #Aggregation #Preprint

DBS not effective long term for #SCA3 #MachadoJoseph disease dystonia. @DBSThinkTank this has been consistent with other case reports and underscores that when using for SCA's make sure the palliative effect matches the situation. @DBSThinkTank @leaddbs...