Lipidomic Signatures Reveal Disease Severity and Cardiac Risk in Acromegaly SM 34:0;O2 and phosphorylcholine robustly distinguish acromegaly from controls and track biochemical disease activity.

#Acromegaly is characterized by a distinct serum lipidomic signature in which #Sphingomyelin (SM) 34:0;O2 and phosphorylcholine emerge as discriminative biomarkers, with SM 34:0;O2 reflecting disease activity and treatment status.

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In @jcb.org, Kim, Parolek, and Burd @yalecellbiology.bsky.social show that depletion of #cholesterol increases #sphingomyelin synthesis as a result of increased coatomer II–mediated endoplasmic reticulum-to-#Golgi #trafficking of #ceramide, the precursor to sphingomyelin. rupress.org/jcb/article/...

Kim, Parolek, and Burd @yalecellbiology.bsky.social show that depletion of #cholesterol increases #sphingomyelin synthesis as a result of increased coatomer II–mediated endoplasmic reticulum-to-#Golgi #trafficking of #ceramide, the precursor to sphingomyelin. rupress.org/jcb/article/...

Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia

#Multiomics profiling of #schizophrenia patients identified proteins, metabolites, and genetic loci predictive of #Paliperidone efficacy, with higher #phosphatidylcholine and #sphingomyelin levels correlating with better response. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...