A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development - Nature Cell Biology The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is dispensable after epithelium formation. ...

🥂Congratulations to @grazianomartello.bsky.social & co: they optimize an in vitro human #epiblast model, which they use to show that early #TGFβ family inhibition prevents epithelial identity, while it is dispensable after epithelium formation.
👉https://rdcu.be/eVPMa

www.nature.com/articles/s41...

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development - Nature Cell Biology The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is dispensable after epithelium formation. ...

☕The authors optimize an in vitro human #epiblast model, which they utilize to show that early #TGFβ family inhibition prevents epithelial identity, while it is dispensable after epithelium formation. @grazianomartello.bsky.social
👉https://rdcu.be/eVPMa
bit.ly/4pNo2xL

Join us this week for a discussion with Dr. Maneesha Inamdar from the Institute for Stem Cell and Regenerative Medicine (inStem)!

Her team recently published an @elife.bsky.social article on #TGFβ signaling during mouse vascular development.

🔖 Check it out: bit.ly/3FKBVuX

Investigation of roles of #PDGF and #TGFβ signaling in right ventricular #fibrosis, using the dual inhibitor, #Tranilast, reports reduced RV #hypertrophy and improved diastolic relaxation, implicating both growth factors as relevant targets.
doi.org/10.14814/phy...
#Cardiovascular #CardiacFunction

Original post on mastodon.online

#MIS-C, eine seltene, aber schwere Entzündung nach #COVID19 bei Kindern, wird durch die Reaktivierung des #EpsteinBarr-Virus ausgelöst.

Das #Virus, das meist unbemerkt im Körper bleibt, kann durch eine gestörte #Immunabwehr erneut aktiv werden.

Forschende der #Charité haben entdeckt, dass der […]

Nature Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest ...

Our latest study in @nature.com reveals how #TGFβ drives Epstein-Barr Virus (#EBV) reactivation in multisystem inflammatory syndrome in #children (#MISC, #PIMS) following #COVID19.
@drfzberlin.bsky.social @mashreghilab.bsky.social

🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6

Timely TGFβ signalling inhibition induces notochord Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.

Strategic inhibition of TGFβ signaling prompts notochord formation from pluripotent stem cells, filling a key gap in human trunk formation models. Enhances study of tissue patterning! #StemCell #TGFβ #Notochord #Biotech PMID:39695233, Nature 2024, @Nature

Bilateral epithelial cell-fibroblast communications in gastroesophageal junction development

1⃣"fibroblasts predominantly sent FGF & #TGFβ signals to the epithelia"
2⃣"PDGF & EGF signals were sent predominantly from epithelial cells to fibroblasts"

#NatureComms 2024
www.nature.com/articles/s41...