353 participants randomized to receive either bivalent mRNA vaccine (Moderna, n=177) or protein vaccine (Novavax, n=176), with a control group (n=143)
Follow-up at 6 - 12 months measuring antibody responses & #Tcellimmunity

This study has some limitations, such as the inability to investigate IgG anti-S antibody levels after the 1st, 2nd, and 3rd doses of the vaccine; therefore, it was not possible to compare the antibody levels after each vaccination. #Tcellimmunity has not yet been evaluated.

This study shows that CD28–PI3K signaling suppresses PANK4 via #PDK1 to control de novo lipid synthesis, and Pank4 deletion boosts CoA synthesis, #glutaminolysis, and CD4⁺ T-cell proliferation. #TCellImmunity #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, espec...

Age and viral evolution reduce CD4⁺ T cell reactivity to the conserved iCope epitope, while humoral cross reactivity remains mutation sensitive only. 
#ImmuneEscape #TCellImmunity #PanCoronavirus

👤EVBC: Andreas Nitsche
📄

Humoral and T-Cell Responses Following MVA-BN Booster Vaccination Against Mpox Virus Clades Ib and IIb
Antinori, A., Bettini, A. et al.
Paper
Details
#MpoxVaccine #HumoralResponse #TCellImmunity

Understanding T cell responses to COVID-19 is essential for informing public health strategies Deployment of broad-based strategies to measure vaccine-induced T cell immunity can significantly inform public health policies and interventions.

Deployment of existing methods for measuring #Tcellimmunity could provide a more complete profile of immune status, informing #publichealth policies and interventions…

www.science.org/doi/10.1126/...