Empty cognizance ~ Tulku Urgyen Rinpoche
https://justdharma.org/empty-cognizance/
#TulkuUrgyenRinpoche #wakefulness #obscuration #lovingkindness
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Hashtag
#Wakefulness
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The neuronal network of the wakefulness system activated by solriamfetol (Sol), modafinil (Mod) and non-pharmacological wakefulness (NW). Drawing showing many interconnected structures implicated in wakefulness, after Sol, and Mod injections and NW. The pink structures are significatively more activated by Sol than Mod and NW. Sol strongly activates a subset of structures less activated in non-pharmacological wakefulness (NW) and only weekly activated by Mod. The blue structures are activated by Sol, Mod and NW. The white ones are known to be implicated in the wake system, for the DRN, LC and TMN, their role is minor based on our results. Different neurotransmitters are involved in this system inhibiting or exciting wake structures, Like gamma-aminobutyric (GABA), glutamate (Glu), norepinephrine (NA), Histamine (Hist), acetylcholine (Ach), Orexin (Orx), dopamine (DA), serotonin (5HT), oxytocin (OT), vasopressin (VP), corticotropin-releasing hormone (CRH), and calcitonin gene-related peptide (CRGP). ACB: accumbens nucleus, BNSTOval: bed nucleus of the stria terminalis, anterior division, oval nucleus, CEAl: central amygdalar nucleus, lateral part, DRN: dorsal raphe nucleus, LC: locus coeruleus, LDT: laterodorsal tegmental nucleus, LH: lateral hypothalamus, LPBExt: lateral parabrachial nucleus, external part, LRN: lateral reticular nucleus, NTSc: nucleus of the solitary tract, caudal part, PSTN: parasubthalamic nucleus, PVN: paraventricular nucleus of the hypothalamus, PVT: paraventricular nucleus of the thalamus, SO: supraoptic nucleus, TMN: tuberomammillary nucleus, VLPO: ventrolateral preoptic area, VTA: ventral tegmental area. Created in BioRender. Team, S. (2026)
Does #wakefulness induced by pharmacological or non-pharma routes involve different #neurons? This study of whole-brain activation patterns in mouse shows that solriamfetol, modafinil & non-pharma #arousal recruit overlapping but distinct subcortical populations @plosbiology.org 🧪 plos.io/4soFNVK
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The neuronal network of the wakefulness system activated by solriamfetol (Sol), modafinil (Mod) and non-pharmacological wakefulness (NW). Drawing showing many interconnected structures implicated in wakefulness, after Sol, and Mod injections and NW. The pink structures are significatively more activated by Sol than Mod and NW. Sol strongly activates a subset of structures less activated in non-pharmacological wakefulness (NW) and only weekly activated by Mod. The blue structures are activated by Sol, Mod and NW. The white ones are known to be implicated in the wake system, for the DRN, LC and TMN, their role is minor based on our results. Different neurotransmitters are involved in this system inhibiting or exciting wake structures, Like gamma-aminobutyric (GABA), glutamate (Glu), norepinephrine (NA), Histamine (Hist), acetylcholine (Ach), Orexin (Orx), dopamine (DA), serotonin (5HT), oxytocin (OT), vasopressin (VP), corticotropin-releasing hormone (CRH), and calcitonin gene-related peptide (CRGP). ACB: accumbens nucleus, BNSTOval: bed nucleus of the stria terminalis, anterior division, oval nucleus, CEAl: central amygdalar nucleus, lateral part, DRN: dorsal raphe nucleus, LC: locus coeruleus, LDT: laterodorsal tegmental nucleus, LH: lateral hypothalamus, LPBExt: lateral parabrachial nucleus, external part, LRN: lateral reticular nucleus, NTSc: nucleus of the solitary tract, caudal part, PSTN: parasubthalamic nucleus, PVN: paraventricular nucleus of the hypothalamus, PVT: paraventricular nucleus of the thalamus, SO: supraoptic nucleus, TMN: tuberomammillary nucleus, VLPO: ventrolateral preoptic area, VTA: ventral tegmental area. Created in BioRender. Team, S. (2026)
Does #wakefulness induced by pharmacological or non-pharma routes involve different #neurons? This study of whole-brain activation patterns in mouse shows that solriamfetol, modafinil & non-pharma #arousal recruit overlapping but distinct subcortical populations @plosbiology.org 🧪 plos.io/4soFNVK
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The neuronal network of the wakefulness system activated by solriamfetol (Sol), modafinil (Mod) and non-pharmacological wakefulness (NW). Drawing showing many interconnected structures implicated in wakefulness, after Sol, and Mod injections and NW. The pink structures are significatively more activated by Sol than Mod and NW. Sol strongly activates a subset of structures less activated in non-pharmacological wakefulness (NW) and only weekly activated by Mod. The blue structures are activated by Sol, Mod and NW. The white ones are known to be implicated in the wake system, for the DRN, LC and TMN, their role is minor based on our results. Different neurotransmitters are involved in this system inhibiting or exciting wake structures, Like gamma-aminobutyric (GABA), glutamate (Glu), norepinephrine (NA), Histamine (Hist), acetylcholine (Ach), Orexin (Orx), dopamine (DA), serotonin (5HT), oxytocin (OT), vasopressin (VP), corticotropin-releasing hormone (CRH), and calcitonin gene-related peptide (CRGP). ACB: accumbens nucleus, BNSTOval: bed nucleus of the stria terminalis, anterior division, oval nucleus, CEAl: central amygdalar nucleus, lateral part, DRN: dorsal raphe nucleus, LC: locus coeruleus, LDT: laterodorsal tegmental nucleus, LH: lateral hypothalamus, LPBExt: lateral parabrachial nucleus, external part, LRN: lateral reticular nucleus, NTSc: nucleus of the solitary tract, caudal part, PSTN: parasubthalamic nucleus, PVN: paraventricular nucleus of the hypothalamus, PVT: paraventricular nucleus of the thalamus, SO: supraoptic nucleus, TMN: tuberomammillary nucleus, VLPO: ventrolateral preoptic area, VTA: ventral tegmental area. Created in BioRender. Team, S. (2026)
Does #wakefulness induced by pharmacological or non-pharma routes involve different #neurons? This study of whole-brain activation patterns in mouse shows that solriamfetol, modafinil & non-pharma #arousal recruit overlapping but distinct subcortical populations @plosbiology.org 🧪 plos.io/4soFNVK
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Five Ways Sustaining the Essence ~ Dakpo Tashi Namgyal
justdharma.org/five-ways-sustaining-the...
#DakpoTashiNamgyal #wakefulness #mindfulness #awareness
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Study shows #brain areas affected by #StimulantMedications control #reward and #wakefulness, not #attention.
#ADHDmedications #BrainActivity
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A particular taste may directly signal the brain to wake up #Science #HealthandMedicine #Nutrition #BrainHealth #TasteResearch #Wakefulness
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34gallery.org Artist Luetas NFT: “'A goddess who belongs to that moment between #wakefulness & #sleep where everything fades away. She remains. Her body is not defined. It breaks into colors reminiscent of #autumns, #dreams, #farewells."
More: luetas.art
#SDG3 #mentalhealth #arttherapy #echoes
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Although ~ Padmasambhava
https://justdharma.org/although-padmasambhava/
#Padmasambhava #realization #enlightenment #wakefulness
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#sleepheath #drugdevelopment #Eisai #narcolepsy #narcolepsydrug #E2086 #Novelorexinreceptoragonist #wakefulness #WorldSleep2025 #daytimewakefulness #narcolepsytype1 #clinicaltrialparticipants #MaintenanceofWakefulnessTest #MWT #KarolinskaSleepinessScale #KSS #sleeplatency
zurl.co/KAgBH
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#Wakefulness was a daily recurring brain state and state of consciousness in which an individual was conscious and engaged in coherent cognitive and behavioral responses to the external world.
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Experiencing sleep paralysis is terrifying. I wake up unable to move or speak, feeling a heavy weight on my chest. My heart races as I try to cry out but no sound comes out. The room feels oppressive, often with shadowy figures in my periphery. The dread of being trapped in my own body lingers long after the episode ends. It's a chilling experience that shakes me to my core.
#Sleepparalysis is a #distressing experience where you're caught between #wakefulness and #dreams, feeling heavy and immobile. It can be frightening, often accompanied by shadowy figures or a sensed presence, leading to #anxiety and helplessness.
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A cat lounging on the backrest of a chair, drifting between sleep and wakefulness
Drifting between sleep and wakefulness
#miukumauku #cats #cat #catlover #meow #miauw #catsky #catpics #sleep #wakefulness #catsofbluesky #Blueskyねこ部 #chatgpt
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3/ The longer you stay awake, the more #adenosine accumulates in your #brain.
This rising level acts like a gentle nudge toward rest, interacting with A1 and A2A receptors to inhibit #wakefulness.
It’s your body’s way of saying, “Hey, it’s time to recharge!”
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Meaning Behind the Word: Drowsiness #Word #Meaning #Drowsiness #State #Wakefulness #Sleep #Fatigue #Medications #Illness #Effects #Impaired #Performance #Alertness #Prevention
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People with fatty liver disease demonstrated significant fragmentation of their nightly #sleep due to frequent awakenings and increased #wakefulness. #NAFLD #liverdisease #obesity www.healthday.com/health-news/...
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As it is : Urgyen, Tulku, 1920-1996 Free Download, Borrow archive.org/details/asit... via @internetarchive
#Urgyen #Tulku #dzogchen #nyingma
#bardo , #bodhichitta , #bodhisattvas , #Dharma , #dharmadhatu , #dharmakaya , #emptiness , #wakefulness , #rigpa , #sambhogakaya #Vajrayana , #yidam
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Out in @CurrentBiology from Michael Rosbash lab
#light and dopamine impact two circadian neurons to promote morning #wakefulness
www.cell.com/current-biology/fulltext...
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