Histology-based SWM microstructure intensity profile. Top: SWM sampling framework from 3D postmortem histology. The Laplacian field within the white matter domain was solved for each histological classified volume to sample 50 SWM surfaces, spanning from the GM/WM interface to 3 mm into the white matter. These surfaces were then mapped to each histological staining method, allowing the extraction of intensity profiles for each vertex across SWM depths. Bottom: Alterations in the intensity distributions of histological features across SWM depths. The GM/WM interface (0 mm) and 25 representative SWM surfaces (up to 3 mm into the white matter) are shown. The surfaces showing the greatest variation in SWM, from 0 to 1.8 mm into the white matter, were mapped onto the brain alongside the intensity profiles on the left.
How does superficial white matter contribute to large-scale #brain function? @borismontreal.bsky.social &co use an approach based on 3D histology & 7-Tesla MRI to reveal associations between superficial #WhiteMatter microstructure & diverse cortical properties @plosbiology.org 🧪 plos.io/460WNIz