Flexible ensheathment of #axons enables #myelination of complex CNS networks
doi.org/10.1038/s415...
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Hashtag
#Myelination
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One week left to submit your proposal for #GLIA2027, Bologna, 7–10 July 2027.
Deadline: 8 April 2026, 12:00 p.m. CEST
Submit: https://www.glia-meeting.eu/2027/call-for-symposia/
#GlialCells #Astrocytes #Microglia #Oligodendrocytes #SchwannCells #NG2Cells #Neuroinflammation #Myelination
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On Thursday, Feb 26, Melanie Piller will present her Dissertation Defense: "P/Q-type voltage-gated calcium channels regulate #oligodendrocyte lineage
#cell calcium signaling and #myelination during development" at 12pm in Vollum's M1441. #OHSUResearch cc: @melanie-piller.bsky.social
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New APC paper out today in Advanced Science
"The Microbiota Shapes Central Nervous System Myelination in Early Life"
📰 advanced.onlinelibrary.wiley.com/doi/10.1002/...
#GutBrainAxis #Microbiome #Neurodevelopment #Myelination #GlialBiology
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Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.
What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO
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Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.
What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO
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Left: An example image of a filled PV interneuron showing putative autapses with white arrows. Note that all autapses are present in close distance to the soma. Right: Pie charts depicting the percentage of cells showing (1) both structural and physiological autapses, (2) no structural nor physiological autapses, and (3) only structural autapses. Note that only mice that underwent juvenile demyelination have PV interneurons which show structural autapses but no autaptic response.
What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO
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Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)
#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy
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Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)
#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy
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Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)
#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy
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Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)
#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy
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"The hope is that if we understand how this gene facilitates #myelination, then we can develop therapies that restore or promote myelin formation—not just for this rare disorder, but also for diseases like #MultipleSclerosis." medicalxpress.com/news/2025-07...
cc: @volluminstitute.bsky.social
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Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing
#neuroprotection #neurodegenration #oligodendroglia #neurogenesis #microglia #astrocyte #myelination #exercise #singlecell #transcriptomics 🧪
doi.org/10.1038/s415...
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Demyelination Produces a Shift in the Population of Cortical Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells
#neuro #oligodendroglia #OPC #myelination #remyelination #demyelination #neuron #synapse 🧪
doi.org/10.1523/ENEU...
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A group of researchers stand together under a slide that shows the titles of each of their presentations
I spent a fantastic morning presenting some of my PhD work at a session on adult #neurogenesis and central #myelination at #MNS2025 ! This was a great opportunity to share and discuss ideas and research progress.
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Super interesting article. Having recently stumbled inadvertently into the area of #axon #growth / #myelination, I am amazed by how little we know... or am I looking in the wrong place?
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![[Sofia das Neves] Meningeal lymphatic function promotes oligodendrocyte survival & brain myelination](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:clojua4yxcyhwz2hcml5q3r2/bafkreicqpgb3a4rdptvqwndvhpgisfmglc7vbyqedkib223oqs3oel2ysy)
📣 @dasNeves_SP's talk is now on YouTube!
"#Meningeal lymphatic function promotes #oligodendrocyte survival and brain #myelination"
@ImmunityCP
2024
@Da_Mesquita_S
Lab
@MayoClinic
👉 Link: youtu.be/Xt_8bMlWYPU
#openscience
#JoinUs
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Chronic social defeat reduces #myelination in the mouse medial prefrontal cortex https://www.nature.com/articles/srep46548
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