Spotlight: Lwin and Yap highlight work from Soffer and colleagues (rupress.org/jcb/article/...), which suggests that #spectrin mediates the integration of transitions in cell shape with spatial organization signaling by acting as an organizer of the #actomyosin cortex. rupress.org/jcb/article/...
Spotlight @jcb.org: Lwin and Yap highlight work from Soffer et al.(rupress.org/jcb/article/...), which suggests that #spectrin mediates the integration of transitions in cell shape with spatial organization signaling by acting as an organizer of the #actomyosin cortex. rupress.org/jcb/article/...
A quick digest :
#Cellularization runs on two separable modules:
🧭 MTs + #MTOCs → spatial patterning (where furrows go)
⚙️ #Actomyosin + membranes→ mechanical ingression (how furrows grow)
Disrupt either one and the process breaks — but in different ways.
Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/...
#CellSignaling #Cytoskeleton #Development
In @jcb.org, Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/...
#CellSignaling #Cytoskeleton #Development
Remarkably, catenin phosphorylation is sensitive to drugs that modulate #actomyosin contractility. We observed HYPER-phosphorylation on catenins under conditions that promote cell rounding and HYPO-phosphorylation when myosin activity was reduced. (4/7)
#Microtubule-driven cell shape changes and #actomyosin flow synergize to position the #centrosome, say Alexandre Schaeffer, Manuel Théry (@manuelthery.bsky.social ) and colleagues: rupress.org/jcb/article/...
@lblanchoin.bsky.social
@gelinmatthieu.bsky.social
#Biophysics #Cytoskeleton
Dr. Seham Ebrahim discovered #actomyosin lattices associated with secretory granules. Amazing #intravital microscopy at high resolution, check it out here:
nature.com/articles/s4155…
Dr. Seham Ebrahim discovered #actomyosin lattices associated with secretory granules. Amazing #intravital microscopy at high resolution, check it out here:
nature.com/articles/s4155…
