This review highlights #mtDNA leakage as a driver of #CellularSenescence and the SASP, activating cGAS–STING, #TLR9, and #NLRP3, while exploring strategies to block release or downstream sensing to combat #AgingRelatedDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

🧬 Cellular Senescence: The Zombie Cells Within Us

The future of longevity? Senolytics - drugs that selectively eliminate these zombie cells, potentially reversing aspects of aging.

#CellularSenescence #AgingResearch #Longevity #Senolytics #RegenerativeMedicine #Geroscience

🔆 #PaperSpotlight:
A new #editorial was #published on February 8, 2026, titled “Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?” @uconn.bsky.social

🔗 www.aging-us.com/article/2063...

#aging #quote #cancer #cellularsenescence #openaccess

Really grateful for the chance to share my journey across Europe and the U.S.
looking forward to it!

#ICSA #cellularsenescence #agingresearch #academia #senolytics #geroscience

New insights connect ageing biology with pathways driving neurodegeneration, revealing targets for prevention and therapy.
#AntiAgeing #Neurodegeneration #CellularSenescence #TherapeuticTargets
www.nature.com/articles/s41...

📣 Looking for a new Review to read this week?

Overview of molecular signatures of senescence and associated resources: pros and cons

➡️ buff.ly/QjHFhzr

#Senescence #CellularSenescence #Ageing

Overactive Runx1 Gene Triggers Early Disc Degeneration Linked to Aging | Aging Taken together, these findings reveal a novel role of Runx1 in maintaining disc health and regulating age-related degenerative processes."Click here to listen to the press releaseBUFFALO, NY — Oc...

📈 #TrendingWithImpact:
This #research paper was #published in Volume 17, Issue 9, titled "Runx1 overexpression induces early onset of intervertebral disc degeneration."

#PressRelease ⬇️
www.aging-us.com/news-room/ov...

#aging #press #runx1 #cellularsenescence #oa #publishing #journal

📈 #TrendingWithImpact:
A new #research paper was #published on September 8, titled “Runx1 overexpression induces early onset of intervertebral disc degeneration.”

🔗 doi.org/10.18632/agi...

#aging #quote #cellularsenescence #runx1 #openaccess #publishing

🎥 #AgingShort:
Abstract #video about this #research paper, titled “Runx1 overexpression induces early onset of intervertebral disc degeneration.”

🔗 doi.org/10.18632/agi...

#aging #TrendingWithImpact #cellularsenescence #runx1 #skeletalsystem #openaccess #publishing

This recent review explores #CellularSenescence in #IntervertebralDiscDegeneration, summarizing detection methods, #RegulatoryMechanisms, & therapies to inhibit #Senescence, & also addresses the challenges in #Clinical applications. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

🔥Exciting science at ERIBA seminar! 🔥
Our Postdoc @jamilnehme.bsky.social presented his research on cell fate decisions in response to damage and the broader implications for health and disease. Inspiring insights into life’s resilience!
#aging #cellularsenescence #science

🎥 #AgingShort:
Abstract #video about the #research paper, "Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction." @buckinstitute.org

🔗 doi.org/10.18632/aging.206299

#aging #PaperSpotlight #cellularsenescence #oa #publishing

Excited to dive into fascinating science on cellular senescence! @yicsac.bsky.social @icsasenescence.bsky.social
#CellularSenescence #Aging #ICSA2025 #yICSA”

Farewell to @magnusberglind.bsky.social 👋
After two months in our lab, it was great having you around. We really enjoyed you being part of the team, both for your work and the fun moments.
Good luck with what’s next, we’re sure you’ll do great 🚀 #labteam #cellularsenescence #aging

Increased serum MMA levels upregulate MAFB, ana novel age-dependent #biomarker for #Osteosarcoma, and drive #TranscriptionalReprogramming of the MAFB-NOTCH3 axis to accelerate, accelerating osteosarcoma progression via through activation of the PI3K-AKT pathway. #CellularSenescence

buff.ly/lzUBVq2

Loved the mix of science, good conversations, and familiar faces. Already looking forward to the next one!

#PhDLife #CellularSenescence #KarolinskaInstitute #yICSA #ResearchCommunity #Gratitude

@akispapantonis.bsky.social seminar, moderated by @stefanschoenfelder.bsky.social : Senescent cells repurpose proteins to cluster CTCF, rewiring genome architecture.
Recording: www.youtube.com/watch?v=6NtH...
Next "3D Regulatory Genome" speaker coming soon!
#CellularSenescence #GenomeRegulation

Cellular Senescence Explained: How Zombie Cells Accelerate Aging and How to Fight Back! Learn how zombie cells drive aging & disease. Discover senescence, its risks, and senolytics—therapies aiming to clear these aging cells.

Discover how zombie #cells drive #aging and #disease, and explore emerging #senolytictherapies that may reverse the damage. Visit now to learn more.

Visit BlogPost 🔗: www.healthandfitnessposts.site/2025/04/Cell...

#cellularsenescence #zombiecells #senolytics #antiaging #longevity #AgeingWell

Biomarkers of Cellular Senescence and Skin Aging Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging stimuli, including DNA damage, telomere shortening and dysfunction or oncogenic stress. Senescent…

Uncover more insights in this paper ▶️ Biomarkers of Cellular Senescence and Skin Aging buff.ly/s3REAhs

#cosmeticscience #longevity #cosmeticchemist #skincare #cellularsenescence #innovation

Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...

Researching #cellularsenescence? Study in @naturecomms.bsky.social highlights new open-source software that can find senescent cells in organs and tissues. Scientists at University of Illinois, Chicago identified 72 mouse and 64 human signatures in various organs www.nature.com/articles/s41...

Last Friday, Alessio Piccolantonio (@apiccolantonio.bsky.social) from our lab presented his PhD project at his first ERIBA seminar, exploring the role of cellular senescence in systemic sclerosis🔬🧬🧫 #Science #Research#CellBiology #Aging #CellularSenescence

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts - GeroScience Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffne...

Many age-related diseases involve fibrosis. Study in @geroscience.bsky.social shows mechanical forces shape #cellularsenescence and related secretory phenotypes. Researchers in Winer lab ID’d unique high-stiffness-driven secretory protein profiles link.springer.com/article/10.1...

Follow me for #CellularSenescence related stuff, science in general, life as a PI, and occasionally also books-music-films
Sometimes in English, a veces en español

Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases - Nature Reviews Molecular Cell Biology Heterochromatin loss, telomere attrition and DNA damage induce cellular senescence by eliciting genome instability and innate immunity responses, thereby promoting ageing and age-related diseases. Thi...

Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. #Chromatin #GenomeInstability #CellularSenescence #Ageing #Genomics #BioSky #SciSky 🧪
www.nature.com/articles/s41...

Protein Modification May Hold Key to Reversing Cellular Aging Summary: Scientists have discovered that inhibiting protein palmitoylation can partially reverse cellular senescence in human vascular smooth muscle

New study reveals protein modification's role in cellular aging. Could lead to therapies for age-related diseases #AgingResearch #CellularSenescence scienceblog.com/547652/prote...

RUNX1 mutations contribute to the progression of MDS due to disruption of antitumor cellular defense: a study on patients with lower-risk MDS Leukemia - RUNX1 mutations contribute to the progression of MDS due to disruption of antitumor cellular defense: a study on patients with lower-risk MDS

With a lot of support from friends @FricLab makes first baby-steps helping in haemato-oncology research. @uhkt_cz @FNUSA_ICRC #CellularSenescence #MyelodisplasticSyndromes @IHBTcelltherapy

doi.org/10.1038/s41375…