Allosteric binding cooperativity in kinases signaling, signalopathies, and drug development Protein kinases catalyze the transfer of phosphate groups from ATP to specific substrates, initiating, modulating, or terminating signaling cascades. …

A nice review on #cooperativity in #kinases - I think exploiting these properties may be the way we can forgo some of the tox that is dose limiting in the clinic associated with kinase inhibitors #medchem

www.sciencedirect.com/science/arti...

If you are interested in #transcription factors, DNA-binding #cooperativity and intrinsically disordered regions #IDRs, check out our study where we dissect the molecular interplay between two human TFs on #DNA.
doi.org/10.1016/j.ij...

DNA-guided transcription factor cooperativity shapes face and limb mesenchyme Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving re…

Very nice study finding TF cooperativity driven by a specific DNA motif, and going all the way from ChiP-seq and CUT&RUN data to crystal structures and analysis of human facial variation! #Epigenetics #NeuralCrest #Cooperativity www.sciencedirect.com/science/arti...?