Revealing misannotated electrospray ionization artifacts: A systematic pipeline for heterodimer detection in untargeted metabolomics Heterodimers are non-covalent adducts formed between two co-eluting molecules during electrospray ionization (ESI). Despite their frequent occurrence …

Looking for a clear, systematic, and practical pipeline to detect and validate #heterodimers consistently in #LCMS and #CEMS-based #untargeted #metabolomics? www.sciencedirect.com/science/arti... #darkmetabolome

#Weekend Read

🔦The “dark metabolome” isn’t a myth, it’s a frontier.

New research shows most unannotated signals in metabolomics are **not just fragmentation artefacts**, but real, undiscovered molecules. 🚀

🔗bit.ly/4pSxDUD

#Metabolomics #DarkMetabolome #MassSpec

The Past, Present, and Future of the “Dark Metabolome” Oliver Jones traces the evolution of a contested concept – and what it means for the future of metabolomics

The “dark metabolome” has sparked debate in metabolomics. 🌌

Oliver Jones (RMIT) traces its past, present, and future – and why careful scrutiny matters.

👉 Read more in our ongoing series: https://ow.ly/vC0I50X2b5O

#Metabolomics #DarkMetabolome

This looks to be a magnificent and essential contribution to the field. Sadly essential because of the urgent need to dispell misinformation circulating about the #darkMetabolome and the prevalence of in-source fragmentation artifacts in #metabolomics data.

The #DarkMetabolome remains a significant frontier for discovery, holding countless unannotated features that could potentially represent novel molecules. The development of powerful bioinformatics tools is crucial in unlocking the secrets held within this chemical space.

🗣🗯️ The #DarkMetabolome Debate: Are unknown signals just measurement artefacts?

‼️ #MassSpectrometry does produce different ion forms but claiming the metabolome is mostly known is misleading ‼️

📄 Read the original publication: doi.org/10.1038/s422...

#UntargetedMetabolomics

⬇️ Read more below ⬇️

If you’re into #metabolomics research, check out this @nature.com article. It dives into how our body’s metabolism shapes health at the molecular level, offering fascinating insights! #DarkMetabolome #ComputationalBiology #Bioinformatics #ResearchSky