LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis
MEG3, a #lncRNA, suppresses #EpithelialMesenchymalTransition in #BladderCancer by binding Snail to prevent #Ecadherin repression and inhibiting ERK/JNK/P38 signaling, reducing invasion and migration—highlighting its promise as a therapeutic target.
Read: doi.org/10.1007/s115...
Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor
#SingleCellAnalysis reveals #ATF6 drives #EpithelialMesenchymalTransition in #LensEpithelialCells, promoting #fibrosis & #cataract progression; inhibiting ATF6 reduces #STAT3 activation, highlighting ATF6–TAK1 signaling as a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition
Elevated #FPR1 drives #inflammation and #EpithelialMesenchymalTransition in #FetalMembranes during premature rupture, while the BOC-MLF reduces inflammation and preserves #collagen structure, highlighting a potential preventive strategy for PROM.
Read: doi.org/10.1007/s115...
The #E3ligase #UBR5 suppresses #ColorectalCancer by driving #ubiquitin‑mediated degradation of #Snail, limiting #EpithelialMesenchymalTransition & invasion; low UBR5 predicts poor prognosis, highlighting the UBR5–Snail axis as a #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
This study reveals that formyl peptide receptor 1 (FPR1) is upregulated in #PrematureRuptureofMembranes (PROM) patients, promoting #EpithelialMesenchymalTransition & #Membrane weakening, positioning FPR1 as a promising target for PROM prevention. #medsky
See:
This study reveals that #lncRNA #Maternally expressed gene 3 (MEG3) suppresses #EpithelialMesenchymalTransition by modulating #Ecadherin via Snail/#MAPK regulation, positioning MEG3 as a potential #therapeutic target for #BladderCancer. #medsky
To read:
New cataract research!
This study links NR2F1 to #EpithelialMesenchymalTransition in cataracts, and silencing NR2F1 reduces #lens opacity by inhibiting the STAT3 pathway, making it a promising therapeutic target for fibrotic #cataracts. #medsky
#OpenAccess:
This review summarizes the roles of #EpithelialMesenchymalTransition (EMT) in #glioblastoma initiation and progression, its impact on #cancercell behavior, and the challenges of targeting EMT in therapy, highlighting potential strategies to improve treatment outcomes. #medsky
buff.ly/FJ4bvv9
UBR5 regulates the progression of colorectal cancer cells through Snail-induced epithelial–mesenchymal transition
UBR5, an E3 ligase, promotes the degradation & polyubiquitination of Snail, thereby inhibiting #EpithelialMesenchymalTransition & tumor invasion in #ColorectalCancer (CRC). However, UBR5 C2768S mutation weakens its ability to regulate the migration & invasion of CRC cells. #medsky
buff.ly/h2lKpUD
Transcription cofactor Hes6 interacts with Twist1 to facilitate EMT and promote gastric carcinogenesis by activating the PI3K/AKT signaling
Hes6 enhances the proliferation, migration, and invasion of #GastricCancer (GC) cells by activating the PI3K/AKT signaling pathway and facilitates the #EpithelialMesenchymalTransition of GC cells by stabilizing the Twist1 protein. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Barbora’s review is out, congratulation @BKvokackova!
#triplenegativebreastcancer #plasticity #epithelialmesenchymaltransition #metastasis
Thanks @MeningoJan and @mkjolly15 for great collaboration!
👉
mdpi.com/2072-6694/13/9…
