This review shows how aberrant #fucosylation drives digestive #inflammation and #cancer, covering #GeneticRisks, glycan #biomarkers, molecular mechanisms in intestine, stomach, liver, pancreas, and emerging therapies.
#OpenAccess: doi.org/10.1016/j.ge...
FUT8-mediated core #fucosylation stabilizes TMEM67 to promote #ciliogenesis, say Difei Wang, Huijie Zhao, Jun Zhou and colleagues (Shandong Normal University): rupress.org/jcb/article/...
#Cilia #Disease
In @jcb.org, Wang et al. show that FUT8-mediated core #fucosylation stabilizes TMEM67 to promote #ciliogenesis and that FUT8 deficiency in mice causes ciliary defects in multiple organs. rupress.org/jcb/article/...
#Cilia #Disease
A review on the effects of #fucosylation in digestive inflammatory diseases and #cancers, focusing on aberrant fucosylated glycans as diagnostic #biomarkers and the therapeutic strategies targeting fucosylation by fucose or fucosylation inhibitors. #medsky
#OpenAccess:
Wang et al. show that FUT8-mediated core #fucosylation stabilizes TMEM67 to promote #ciliogenesis and that FUT8 deficiency in mice causes ciliary defects in multiple organs. rupress.org/jcb/article/...
#Cilia #Disease
The study found that both 💉 & infection groups showed decreased #fucosylation of IgG1, which is associated with a proinflammatory biosignature. However, vaccination also leads to increased galactosylation & bisection of IgG antibodies,
Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation
This comprehensive review provides an overview of the current knowledge regarding the role of #fucosylation in #InflammatoryDiseases and #cancers, as well as the diagnostic biomarkers and potential therapeutic strategies. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation
This comprehensive review provides an overview of the current knowledge regarding the role of #fucosylation in #InflammatoryDiseases and #cancers, as well as the diagnostic biomarkers and potential therapeutic strategies. #medsky
#OpenAccess: www.sciencedirect.co...
