OsLdh3 interacts with #OsGAPC3 and OsLos2 to maintain the #glycolytic continuum for tolerance to multiple #abiotic stresses in #rice
academic.oup.com/jxb/advance-...
#PlantScience @jxbotany.bsky.social @sebiology.bsky.social @ricegeek.bsky.social @engagedroadmap.bsky.social @cyi12.bsky.social
A lactate-driven PGAM1–Chk1 interaction sustains #glycolytic reprogramming and #DNARepair in #SenescentCells via HIF-2α/FoxM1 signaling; disrupting this axis induces #senolysis, improves #aging phenotypes, and reduces #LungFibrosis.
#OpenAccess in #STTT: doi.org/10.1038/s413...
3 bromopyruvic acid enhances the efficacy of interventional #embolization in #HepatocellularCarcinoma by targeting #glycolytic enzymes and subsequently inhibits the glucose energy metabolism of tumor cells. #Hypoxia #medsky
Read: link.springer.com/article/10.1...
Using #ChIPseq, we next interrogated what genes were direct targets of #Irf2 in young #female #macrophages, which revealed that #Hk3 (encoding for hexokinase, the rate-limiting enzyme of glycolysis) is repressed by #Irf2, providing a mechanism for female-specific age-related #glycolytic shift. 12/13
Experimental design for functional profiling
Phagocytosis assay
lactate-Glo assay
Indeed, we observed a #SexDimorphic remodeling of #macrophage function with #aging ⏳: female-specific decrease in Zymosan #phagocytosis and increase in #glycolytic output! We also identified 2 genes, #Rps6ka3 and #Magt1 as likely mediators of the female-specific #phagocytosis phenotype. 6/13
