A lactate-driven PGAM1–Chk1 interaction sustains #glycolytic reprogramming and #DNARepair in #SenescentCells via HIF-2α/FoxM1 signaling; disrupting this axis induces #senolysis, improves #aging phenotypes, and reduces #LungFibrosis.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This study identified a largely predominant #SenescentCell population and a minority proliferative cell in GCMN and showed that anti-Bcl2 therapy eliminates GCMN by inducing #Senolysis and #Immunosurveillance. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Therapeutic opportunities for #Senolysis in cardiovascular disease

#Atherosclerosis
#MyocardialInfarction
#HeartFailure
#CardioOncology
#PulmonaryHypertension

Jesús Gil lab #FEBSJ 2023
febs.onlinelibrary.wiley.com/doi/full/10....

Genetic (p16-3MR) vs Pharmacological (ABT263) #Senolysis in ApoE-/-🐭#Atherosclerosis

p16-3MR: No benefits
ABT263:⏬lesion👉senolyis+leukocyte depletion

Proliferating Mφ are also p16+;SAβGal+
🧐#Senescence in situ?

Martin Bennett lab #CardiovascRes 2022
academic.oup.com/cardiovascre...

Death-Seq

Genome-wide CRISPR screening of Death regulators in adherent cells

Sequencing CRISPR libraries in detached vs attached cells

FoxF1 as #Senolysis targtet? Fig 7B😆

Adapted for Adhesion/Extrusion?

Thomas Rando lab Cell Metab 2023
www.cell.com/cell-metabol...