The highest resolution DNA-free TaXPD structure to date uniquely resolves loop 510–514 in the long-form, DNA-free TaXPD model #XRayCrystallography #Helicases #Archaea doi.org/10.1107/S205...

ATP-Powered Proteins Beyond Kinases – and Why Helicases Are Stealing the Spotlight - Promega Connections This blog was written by guest author Michael Curtin, Senior Product Manager, Small Molecule Drug Discovery. ATP is the universal energy currency of cells, and thousands of proteins outside the kinase family “spend” it to move cargo, remodel nucleic acids, pump ions, or fold proteins. These ATP-hydrolyzing enzymes—collectively known as ATPases—span functional classes including motor […]

Helicases are emerging as drug targets. Their ATP hydrolysis is tied to DNA/RNA unwinding and protein displacement, making them strong candidates for assays like ADP-Glo™.

Read more at: https://tinyurl.com/HelicasesBlog 

#Helicases #DrugDiscovery

The complete structure of the human TFIIH core complex The structure of human transcription factor IIH, a critic...

Our TFIIH paper, previously posted on @biorxivpreprint, has now been published in @eLife: The complete structure of the human TFIIH core complex. Interested in #transcription, #DNArepair, #helicases, or #VPP (phase-plate) #cryoEM? Have a look! https://elifesciences.org/articles/44771