The chemokine #CXCL9 has proven to be a reliable peripheral #blood biomarker of interferon-γ-driven #HLH, with elevated CXCL9 identifying adults with HLH who were at high risk for early mortality, irrespective of the underlying disease trigger: https://ow.ly/lj2r50Ym2fk
#HemeSky #MedSky
HLH 24 weeks into pembrolizumab. Steroids failed. Anakinra worked.
Takeaway: Not all irAEs respond to corticosteroids. In severe irAEs, when do you pivot beyond steroids?
Read more: www.cureus.com/articles/455...
#Cureus #Oncology #Immunotherapy #HLH #MedSky
NEW podcast episode🎧
Acting Deputy Editor, Aisling O'Brien, talks to Fiona Pearce & Rachel Tattersall about #HLH mortality rates in Europe
Listen now
Apple: bit.ly/3Off8LR
Spotify: bit.ly/3OFqGYM
Full Article: bit.ly/4p5f9hT
#Medsky #Rheumsky
Our Feb 2026 issue is live!
Including total versus partial knee replacement, vagus nerve stimulation in hand #OA, mortality due to #HLH, #pregnancy outcomes in #vasculitis, plus much more! thelancet.com/journals/lan... #Medsky #Rheumsky
Cover art by @emma-cheng.bsky.social
This case shows how COVID-19 plus occult EBV-positive lymphoma crossed the immunologic threshold, and how early H-score + steroids changed the outcome.
Read more: www.cureus.com/articles/429...
#Cureus #HLH #Hematology #InternalMedicine #MedSky
Crude mortality rates of haemophagocytic lymphohistiocytosis by age and sex in Europe (2011–21). Bars are 95% CI.
NEW RESEARCH—Trends in mortality due to haemophagocytic lymphohistiocytosis across 29 European countries from 2011 to 2021: a retrospective, international, population-based study bit.ly/4p5f9hT #HLH @racheltattersall.bsky.social
A systematic review of disseminated HSV in pregnancy (including with HLH) - out now. Highlights non-specific symptoms of the disease in pregnancy & how an absence of lesions does not exclude HSV in the unwell, febrile pregnant patient.
#sepsis #HSV #HLH
obgyn.onlinelibrary.wiley.com/doi/10.1111/...
#HLH, #Trisomy21, immune dysregulation ...
Case conf webinar featuring:
*** Joaquin Espinosa (espinosalab.org) ***
Thursday 13 November, 11AM ET
Register at
us02web.zoom.us/webinar/regi...
@clinimmsoc.bsky.social
The premiere event, HeartLand Howloween 2025, numbers are:
Registrations: 467;
Attendance: 428.
#HeartLandHowloween #HLH
Annnnd THATS A WRAP to #HeartlandHowloween #HLH
This was a WONDERFUL furst for NE, and I am so happy that I got to be a part of furry midwest history. Tremor and I had a wonderful time; thank you to the staff, volunteers, and all the cuties that came. Can’t wait to see all y’all next year!!
To all of you lovely beans heading out to #HLH #HeartlandHowloween this fantastic weekend, I cannot wait to see every single heckin one of y’all there. Down below is the ways to hunt me down! Love all y’all and can’t wait to be back on the con floor!!
Please check this out and come back often 🐾
#repost #rescue #adopt
#HopeLivesHere #hlh #yeg
hlhfundraising.com?fbclid=IwY2x...
Releyendo a @paulkirschner.bsky.social y @carlhendrick.substack.com en #HLH, os comparto una infografía basada en el último capítulo de su libro sobre diez creencias populares en educación y cómo los autores las tratan.
Ya disponible en domingochica.com/recursos/
#EBT #CogSci
Targeting #NLRP3 with BET inhibitors limits disease in the cytokine storm syndrome, secondary hemophagocytic lymphohistiocytosis #HLH
www.science.org/doi/10.1126/...
Drs. Manson & Tattersall have led a UK-wide effort to bring consistent, excellent #HLH care to their institutions & the broader @england.nhs.uk ... & tracking their outcomes.
Please register: us02web.zoom.us/webinar/regi...
Histiocyte Society #HLH Webinar
"Multi-disciplinary Approach to Managing HLH"
Headlined by @racheltattersall.bsky.social and Jessica Manson, @ucl.ac.uk who've really brought HLH excellences to @england.nhs.uk
July 24th, 11AM NY/8AM SF/4PM UK/5PM CET
Details and link are forthcoming
"Modeling the #HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death"
We're pretty excited about this one.
doi.org/10.1182/bloo...
Thank you!!
I'm coming out of the last 7 years fighting for my life (beating a terminal diagnosis). I'm trying to make sence of everything. I still hurt so much.
I'm alive because of Canadain and/Scottish Universal Healthcare.
#pidd #hlh #cvid #tcell #bcell #lymphoma #stemcelltransplant
As a survivor of HLH (and a bunch of other stuff) this video was helpful for me to understand in a non scary accessible way.
Bless Cincinnati Hospital.
#chronicillness
#hlh #pidd #cvid #Immunodeficiency #immune
youtu.be/Vxoy5328MZc?...
youtu.be/Vxoy5328MZc?...
#HLH #CVID #immunesystem
Are there any people or kids out there that survived HLH? I did after my 1st stem cell transplant to save me from stage 4 t-cell lymphoma. They gave me a second transplant after 5 months and over 200 transfusions.
I'd like to connect and ask about your experience.
@bethangoulden.bsky.social also has an interest in the rare condition #HLH in pregnancy and is leading a 5 years UK wide prospective study in this www.npeu.ox.ac.uk/ukoss/curren.... Check her out in action carrying out her prize winning talk on this very subject at the #MOMS Conference 👇
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Epstein–Barr virus ( #EBV) infection can lead to a potentially lethal syndrome called haemophagocytic lymphohistiocytosis ( #HLH)."
"HLH is characterised by uncontrolled lymphocyte proliferation and macrophage activation."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The patient clinically deteriorated with persisting fever, orthostatic hypotension and hepatosplenomegaly. Bone marrow examination showed haemophagocytic lymphohistiocytosis ( #HLH)."
