#immunology #immunosky #Bcell #immunogenetics

- Atypical Memory #BCell Enrichment: Expanded B-cell clones in PEA+ patients are disproportionately found within the atypical memory subset rather than classical memory pools.
-Genetic Motifs: These clones exhibit a significant overrepresentation of RKH/Y5 heavy-chain motifs,

Thrombotic complications in #longCOVID resemble those in acute
infection,suggesting a shared mechanism.
The development of prothrombotic platelet activating antibodies is strongly associated with the selective expansion of atypical memory #Bcell (atMBC)clones & a coordinated inflammatory environment

Another B-Cell Drug for Lupus Hits the Mark Phase III results put obinutuzumab in line for approval

" #Obinutuzumab ( #Gazyva ) appears set to add systemic #lupus erythematosus ( #SLE ) to its list of approved indications, as results from a phase III trial showed it was significantly more effective than placebo, with no new safety concerns.": buff.ly/WWFikk5

via @medpagetoday.com
#BCell #MedSky

H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability H195Y mutation of transcription factor IKZF3 impairs transcription repression activity and increases protein stability.

New data from Heidi Rysan, @rdekoter.bsky.social and colleagues @schulichmeddent.bsky.social - "H195Y mutation of #IKZF3 identified in a mouse model of precursor #Bcell acute lymphoblastic #Leukemia impairs transcriptional repression activity and increases protein stability"

OUTLOOK: Flicking the switch for B cell development
By Ashley Ng and Stephen Nutt
➡️ https://genesdev.cshlp.org/content/40/3-4/143.full

Also read:
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full

WEHI (The Walter and Eliza Hall Institute of Medical Research) University of Melbourne
#Bcell

RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full

Linköping University @lunduniversity.bsky.social
#hematopoiesis #Bcell #transcriptionfactor #epigenetics

#Medsky🧪#IDsky #immunosky #publichealth #Affinitymaturation in germinal centres (GCs) diversifies the #Bcell response & results in antibodies with improved antigen binding. However, antibodies generated early in a response can reshape ongoing GC selection,

Dr. Facundo Batista at the @ragoninstitute.bsky.social has been named the 2026 recipient of the AAI-BioLegend Herzenberg Award by @aai.org.

The award recognizes investigators who have made outstanding contributions to the field of #BCell biology: https://bit.ly/3Mrw2pQ

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ genesdev.cshlp.org/content/early/2025/11/20...


#hematopoiesis #Bcell #transcriptionfactor #epigenetics

#Medsky🧪 #IDsky #immunosky #Casereport identified a case of very #longCOVID caused by impaired #Bcell –mediated #immunity to #SARSCoV2 in a patient with #Goodsyndrome. Immunoglobulin replacement therapy alone was sufficient to achieve clinical & radiological resolution.

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

This study highlights HZX-02-059, a dual-target inhibitor of #PIKfyve & #Tubulin, as lethal to #Bcell #AcuteLymphoblasticLeukaemia cells, underscoring its potential as a #therapeutic candidate for targeted #CancerTherapy. #medsky
Read: link.springer.com/article/10.1...

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation Myelin-reactive B cells entering the central nervous system capture cognate antigen from the parenchyma. Without T cell help, they rapidly die; however, Epstein-Barr virus LMP1 enables them to bypass ...

📖
“•Naive myelin-reactive B cells enter the brain and capture antigen
•B cells capturing antigen in the brain die by activation-induced cell death
•EBV protein LMP1 can rescue B cells from activation-induced cell death
•B cells rescued after antigen capture induce MS-like lesions”
#Bcell #Antigen

Pathogenic IgE-fated memory B cell responses retain functional plasticity Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling.

#Medsky🧪 #immunosky #publichealth @sciimmunology.bsky.social This study’s demonstrates that the memory #Bcell (MBC) responses responsible for lifelong allergies are not irreversibly committed to producing pathogenic IgE.

www.science.org/doi/10.1126/...

www.science.org/doi/epdf/10....

Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq

🚨Register now for the "2026 Immcantation Users Group Meeting"

🗓️FREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET.

🔗Program & registration: immcantation.github.io/users-meetin...

New research reveals a link between Epstein-Barr virus (EBV) & Primary Sclerosing Cholangitis. Systematic #immuneprofiling shows that #PSC associated T & B cells target #EBV, suggesting it may drive pathogenesis.

www.nature.com/articles/s41...
#Omics #LiverDisease #Autoimmunity #Bcell #Tcell

-Early Antigen Capture: Neutrophils rapidly migrate to injection sites, engulfing antigens & transporting them to lymph nodes, initiating immune activation.
- #BCell Help: They produce 🔑 #Bcell survival factors (BAFF,APRIL) that promote B cell activation, differentiation & robust antibody production

Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.

Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS

& plasmacytes that produce 🦠 -specific high-affinity antibodies. Circulating Tfh cells from #COVID patients support in vitro #Bcell differentiation into antibody-secreting plasma cells & antibody production.

journals.plos.org/plosmedicine...
💉 may promote a more regulated #Bcell response, favoring germinal center reactions with higher somatic hypermutation, which contrasts with the dysregulated extrafollicular #Bcell responses seen in severe COVID cases.

You know what's great about getting a flu shot?

There is an army of twinks like this one in your body that are being stuffed with filthy genetic material until they start squirting antibodies all over the place the the dirty sluts they are.

B stands for Bitch!

#CellsAtWork #HatarakuSaibou #BCell

CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model CD21 initiates extrafollicular differentiation of autoantibody-secreting cells in an SLE model driven by TLR7 signaling.

www.science.org/doi/10.1126/...

📖”This marks a critical point in B cell fate commitment, whereby CD21 down-regulation initiates EF B cell proliferation and differentiation, driving the rapid production of ASCs. “

#Bcell #SLE #lupus

Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice - Nature Communications Plasma cells (PC) contribute to the pathogenesis of autoimmune diseases by secreting autoantibodies. Strategies to target pathogenic PCs are thus required. Here, the authors profile different PC subse...

www.nature.com/articles/s41...

📖 “Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice”

#SLE #lupus #Bcell

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

www.science.org/doi/10.1126/...

“These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.”

#SLE #Bcell #EBV

AMP just published!
"Conjunctival Extranodal Marginal Zone Lymphoma Presenting as Entropion"

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#conjunctivalneoplasms #entropion #lymphoma #bcell #actamedicaportuguesa

Discovering Heterogeneous Leukocytes Subsets Associated With Alcoholic Steatohepatitis by scRNAseq Analysis In this study, we explored comprehensive profiling of heterogeneous immune leukocytes at a single-cell level using scRNAseq analysis to discover the regulation of inflammatory-mediated liver fibrosis...

#Article in @MedComm_MC
Discovering Heterogeneous Leukocytes Subsets Associated With Alcoholic Steatohepatitis by #scRNAseq Analysis doi.org/10.1002/mco2...

#AlcoholicLiverDisease #AlcoholicSteatohepatitis #Bcell #ImmuneCell #Neutrophil #tSNEs

As #ACRConvergence unfolds, one session really stood out “Driving CAR-T into the Future.”
With discussion of next-gen #Bcell targets (CD19, CD20, BCMA, autoreactive subsets), the field is moving from broad depletion to tailored immune precision.

#Lupus #AutoimmuneDisease #CARTcells

that actively promote the development of broadly neutralizing #Bcells. This could lead to more durable #immunity against a wider range of current & future variants.
- The superior ability of booster 💉 to broaden #Bcell #immunity can inform #publichealth strategies

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

scim.ag/46IjMJ0
The process of #Bcell broadening
- After the booster 💉the immune sys recalls & reactivates mBcells created during previous vaccinations or infections. This process boosts the production of antibodies that are specific to the original viral strain.

#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Based on a study in @sciimmunology.bsky.social , a #covid booster immunization drives a germinal center mediated broadening of #Bcell responses by recalling existing #memoryBcells