☕The composition of #ExtracellularVesicles (EVs) is central to their function, yet the field lacks systematic characterization. Here Rai et al. perform #proteomic and #lipidomic analyses of circulating human #plasma EVs and create a web tool for data exploration.
bit.ly/3N7xm0Y
Serum #metabolomic - #lipidomic signatures track long-term neurological performance in #MultipleSclerosis
Rose Noroozi, Hui-Hsin Tsai, Ketian Yu...Kathryn C. Fitzgerald
@hopkinsmedicine.bsky.social #biomarkers
link.springer.com/article/10.1...
Summary figure details changes in ether lipid metabolism in obesity as indicated by the lipid ratios, liver micro-array data, and GWAS analysis. Coloured text depicts potential changes in enzymatic activity (green: increase; red: decrease), identified through linear regression analysis, adjusting for age and sex, of 82 lipid ratios and waist circumference in the AusDiab cohort (n = 10,399). Lipid ratios were log2 transformed, mean-centered and scaled to standard deviation. p-values were corrected for multiple comparisons using the false discovery rate method of Benjamini and Hochberg. Scatter plots depict consolidated liver micro-array data of male mice across 74 matched strains (n = 2−3 per strain) after either a high-fat/high-sugar (navy, n = 152) or chow (blue, n = 222) diet for eight weeks.
#Lipidomic profiling has linked plasma #EtherLipids with #obesity. This study analyzes a set of biologically informed lipid ratios to reveal obesity-related alterations in enzymatic activity & #GeneticVariants not apparent in traditional lipidomic analyses @plosbiology.org 🧪 plos.io/41vdrO5
Summary figure details changes in ether lipid metabolism in obesity as indicated by the lipid ratios, liver micro-array data, and GWAS analysis. Coloured text depicts potential changes in enzymatic activity (green: increase; red: decrease), identified through linear regression analysis, adjusting for age and sex, of 82 lipid ratios and waist circumference in the AusDiab cohort (n = 10,399). Lipid ratios were log2 transformed, mean-centered and scaled to standard deviation. p-values were corrected for multiple comparisons using the false discovery rate method of Benjamini and Hochberg. Scatter plots depict consolidated liver micro-array data of male mice across 74 matched strains (n = 2−3 per strain) after either a high-fat/high-sugar (navy, n = 152) or chow (blue, n = 222) diet for eight weeks.
#Lipidomic profiling has linked plasma #EtherLipids with #obesity. This study analyzes a set of biologically informed lipid ratios to reveal obesity-related alterations in enzymatic activity & #GeneticVariants not apparent in traditional lipidomic analyses @plosbiology.org 🧪 plos.io/41vdrO5
Summary figure details changes in ether lipid metabolism in obesity as indicated by the lipid ratios, liver micro-array data, and GWAS analysis. Coloured text depicts potential changes in enzymatic activity (green: increase; red: decrease), identified through linear regression analysis, adjusting for age and sex, of 82 lipid ratios and waist circumference in the AusDiab cohort (n = 10,399). Lipid ratios were log2 transformed, mean-centered and scaled to standard deviation. p-values were corrected for multiple comparisons using the false discovery rate method of Benjamini and Hochberg. Scatter plots depict consolidated liver micro-array data of male mice across 74 matched strains (n = 2−3 per strain) after either a high-fat/high-sugar (navy, n = 152) or chow (blue, n = 222) diet for eight weeks.
#Lipidomic profiling has linked plasma #EtherLipids with #obesity. This study analyzes a set of biologically informed lipid ratios to reveal obesity-related alterations in enzymatic activity & #GeneticVariants not apparent in traditional lipidomic analyses @plosbiology.org 🧪 plos.io/41vdrO5
At #ASMS, Dr Tong Shen gave two excellent talks. At the ThermoFisher seminar, she explained how extended dynamic range enables #exposome measurements in Alzheimer Disease human blood samples. In the Imaging section, she provided #lipidomic changes in an #Alzheimer’s rat model. Great lively debate!
Dr. Erin Baker of University North Carolina will deliver the plenary lecture at the 6th Annual Canadian #Metabolomics Conference in Montreal next week! Don’t miss her talk on #lipidomic shifts from chemical exposures — Thurs, Apr 24 | 4:05–4:45 PM. Register now: app.groupize.com/organization...
... a #lipidomic analysis of P. gingivalis and report several previously unidentified lipid families. Read the full, open-access story in JLR!
#massspec #massspectrometry #teammassspec
