Gero unveils AI model for small molecule design without structure ProtoBind-Diff generates novel compounds from protein sequence alone – a potential accelerant for early-stage discovery in aging biology.

Gero unveils AI model for small molecule design without structure
ProtoBind-Diff generates novel compounds from protein sequence alone – a potential accelerant for early-stage discovery in aging biology.
#longevity #longevityinnovation #AI

Shift improves virtual cell model ranking for gene discovery New study proposes metrics to refine perturbation model benchmarking and accelerate rejuvenation target identification.

Shift improves virtual cell model ranking for gene discovery
New study proposes metrics to refine perturbation model benchmarking and accelerate rejuvenation target identification.
#longevity #longevityinnovation #AI

Neuronal glycogen metabolism linked to dementia protection Buck Institute study reveals how sugar breakdown in neurons supports redox balance and may counter tau-driven neurodegeneration.

Neuronal glycogen metabolism linked to dementia protection
Buck Institute study reveals how sugar breakdown in neurons supports redox balance and may counter tau-driven neurodegeneration.
#longevity #longevityinnovation

Dogs, data and the drive to decode aging New study maps aging markers in dogs and investigates stem cell therapies, prompting discussion on translational relevance and rigor.

Dogs, data and the drive to decode aging
New study maps aging markers in dogs and investigates stem cell therapies, prompting discussion on translational relevance and rigor.
#longevity #longevityinnovation #aging

Aging by function, not by numbers New epigenetic clock measures intrinsic capacity, predicting mortality and offering a potential route through regulatory deadlock.

Aging by function, not by numbers
New epigenetic clock measures intrinsic capacity, predicting mortality and offering a potential route through regulatory deadlock.
#longevity #longevityinnovation #diagnostics

Estrogen-related receptors emerge as key to muscle energy Salk study finds ERRs as vital to mitochondrial regulation and potential targets for therapies addressing aging and metabolic decline.

Estrogen-related receptors emerge as key to muscle energy
Salk study finds ERRs as vital to mitochondrial regulation and potential targets for therapies addressing aging and metabolic decline.
#longevity #longevityinnovation #aging

Senescent neurons linked to chronic pain in aging Stanford and Rubedo researchers identify pain-driving neurons with senescent signatures, opening new preclinical therapeutic pathways.

Senescent neurons linked to chronic pain in aging
Stanford and Rubedo researchers identify pain-driving neurons with senescent signatures, opening new preclinical therapeutic pathways.
#longevity #longevityinnovation #chronicpain #aging

AI and senolytics: Targeting brain aging at the cellular level University of Copenhagen receives Longevity Science Foundation grant to develop selective senolytics for neurodegeneration.

AI and senolytics: Targeting brain aging at the cellular level
University of Copenhagen receives Longevity Science Foundation grant to develop selective senolytics for neurodegeneration.
#longevity #longevityinvestment #longevityinnovation

Clonal drift in aging blood tracked with natural barcodes Epigenetic lineage tracing offers insight into hematopoietic complexity and its gradual decline with age – without genetic engineering.

Clonal drift in aging blood tracked with natural barcodes
Epigenetic lineage tracing offers insight into hematopoietic complexity and its gradual decline with age – without genetic engineering.
#longevity #longevityinnovation

Modular replacement could reframe how aging is addressed New paper proposes tackling aging organ by organ, cell by cell, using proactive, systemic therapies based on replacement rather than repair.

Modular replacement could reframe how aging is addressed
New paper proposes tackling aging organ by organ, cell by cell, using proactive, systemic therapies based on replacement rather than repair.
#aging #longevity #longevityinnovation

New aging tool maps organ-by-organ decline with clinical precision Researchers create personalized biological clocks that measure how each body system ages – offering a new approach to tracking healthspan.

New aging tool maps organ-by-organ decline with clinical precision
Researchers create personalized biological clocks that measure how each body system ages – offering a new approach to tracking healthspan.
#longevity #longevityinnovation

Mitochondria, metabolism and the aging skeleton New research reveals how disrupted mitochondrial function in cartilage drives skeletal aging through metabolic and signaling imbalances.

Mitochondria, metabolism and the aging skeleton
New research reveals how disrupted mitochondrial function in cartilage drives skeletal aging through metabolic and signaling imbalances.
#longevity #longevityinnovation

Senescent skin cells shown to follow three distinct aging paths New research reveals senescence is not single process but spectrum of cellular states with implications for precision longevity therapies.

Senescent skin cells shown to follow three distinct aging paths
New research reveals senescence is not a single process but a spectrum of cellular states with implications for precision longevity therapies.
#longevity #longevityinnovation #senescence

Photopharmics closes $6 million to advance Parkinson’s device Light-based therapy for Parkinson’s disease moves closer to FDA submission as key trial progresses and Series B extension closes.

PhotoPharmics closes $6 million to advance Parkinson’s device
Light-based therapy for Parkinson’s disease moves closer to FDA submission as key trial progresses and Series B extension closes.
#longevity #longevityinnovation #parkinsons

UK research network explores the gut-brain-immune connection New £4.5m initiative aims to uncover biological mechanisms linking gut health to brain aging, mental health and immune resilience.

UK research network explores the gut-brain-immune connection
New £4.5m initiative aims to uncover biological mechanisms linking gut health to brain aging, mental health and immune resilience.
#longevity #longevityinnovation #longevityeconomy

Engineered microglia offer precision delivery for brain therapies CRISPR-modified human iPSC-microglia respond to Alzheimer’s pathology with therapeutic action, opening new avenues for CNS disease treatment.

Engineered microglia offer precision delivery for brain therapies
CRISPR-modified human iPSC-microglia respond to Alzheimer’s pathology with therapeutic action, opening new avenues for CNS disease treatment.
#microglia #longevity #longevityinnovation

Elevated mitochondrial activity linked to aging blood disorders Metabolic feature of mutant stem cells offers a therapeutic window for managing clonal hematopoiesis and its consequences.

Elevated mitochondrial activity linked to aging blood disorders
Metabolic feature of mutant stem cells offers a therapeutic window for managing clonal hematopoiesis and its consequences.
#longevity #supplements #longevityinnovation

Galatea Bio secures $25m to expand inclusive biobank Company to expand multi-ancestry biobank to support equitable precision medicine through global genomic data integration.

Galatea Bio secures $25m to expand inclusive biobank
Company to expand multi-ancestry biobank to support equitable precision medicine through global genomic data integration.
#longevity #longevityinnovation #longevityeconomy