Take a look at the April issue cover video
youtu.be/_06MjVNNv9s

This video demonstrates the interactive exploration of a #MERFISH skin tissue section using the MERSCOPE Visualizer software. Related article: Düz et al - doi.org/10.1016/j.ji...
#dermsky #SkinBiology #HumanSkin #SingleCell

@vizgen.bsky.social #MERFISH

A new study, led by Kushal (Berkeley), Nicole&Victoria (UCSF) in full collaboration with @karthikshekhar.bsky.social, "Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma" sciencedirect.com/science/arti... #retina #MERFISH

A cool example of what you can do with #MERFISH!

GitHub - HelmholtzAI-Consultants-Munich/oligo-designer-toolsuite: Develop custom oligo design pipelines. Develop custom oligo design pipelines. Contribute to HelmholtzAI-Consultants-Munich/oligo-designer-toolsuite development by creating an account on GitHub.

excited to be on Bluesky now! The oligo-designer-toolsuite developed at @helmholtzai.bsky.social @www.helmholtz-munich.de is for you when you:
🧬 need to design oligos
🧪 use technologies such as #merfish #seqfish #scrinshot
🖥️ design a pipeline for a new technology
github.com/HelmholtzAI-...

Multiplexed FISH methods such as #MERFISH can image 1000s of unique RNA transcripts within single cells, and in turn define a massive diversity of cell types and states within intact tissues. 2/9

Multiplexed FISH methods such as #MERFISH can image 1000s of unique RNA transcripts within single cells, and in turn define a massive diversity of cell types and states within intact tissues. 2/9

SCOPE TEAM has completed 20 @vizgen.bsky.social Merscope 2.0 chemistry runs!!! #spatialbiology #swedishfish #vizgen #Merfish Check out the new chemistry - we love it!

🔬 Explore MERFISH 2.0™ spatial transcriptomics & apply for a free pilot project!
📣 Tech Talk by Dries Van Hemelen
🗓️ May 28, 9:00 AM
📍COS, INF 230, Heidelberg
Hosted by Philipp Mallm
Supported by ‪@mspacealliance.bsky.social‬ -@hlsalliance.bsky.social

#MERFISH #SpatialOmics #Heidelberg #Vizgen

So, As a part of Mermay, I am re-uploading these Merfish Adopts I did last Year. I have 2 batches.
Please find them on my FA.
www.furaffinity.net/view/56547503/
www.furaffinity.net/view/56725115/
$5 USD each.
#mermay #merfish #adopt #adoptable #design

Join us & Global Engage on 5/28 to explore how Vizgen’s new MERFISH 2.0™ chemistry and the MERSCOPE Ultra™ Platform are advancing spatial genomics—unlocking new possibilities for FFPE and archived tissue samples.

Register here: global-engage.com/product/webi...

#SpatialBiology #MERFISH

Free Webinar: Pioneering the Next Era of Spatial Biology with MERFISH 2.0 and the MERSCOPE Ultra™ Platform

📢 Join our FREE webinar!
👉 Register now: lnkd.in/gsWfr4sD
🔗 Event website: lnkd.in/gb6SCHGU
#SpatialBiology #MERFISH #MERSCOPEUltra #Transcriptomics #FFPE #BreastCancerResearch #PersonalizedMedicine #Genomics #LifeSciences #Vizgen #GlobalEngage

Now launched! Vizgen’s new MERFISH 2.0™ delivers up to 10x improvements in transcript detection, expanding spatial biology to more challenging sample types like FFPE tissues.

Early-access users share insights in @genomeweb.bsky.social: www.genomeweb.com/gene-express...

#SpatialBiology #MERFISH

A new pre-print study from researchers at Stanford utilized the MERSCOPE® Platform to reveal how aging alters the function, morphology, and mRNA distribution of microglia.

Read the full pre-print: t.co/RmW36N6zni
#SpatialBiology #MERSCOPE #MERFISH

We welcome @scope-umasschan.bsky.social as a Vizgen Certified Service Provider! 🎉

As a long-time collaborator & early adopter of #MERFISH, SCOPE now provides full-service spatial genomics solutions to accelerate biomedical research using #MERSCOPE Ultra™.

Learn more: vizgen.com/certified-se...

MERFISH 2.0: Redefining #spatialbiology with enhanced chemistry:

✅ Improved RNA anchoring for transcript integrity
✅ Optimized probe binding for precision
✅ Enhanced read-out design for deeper insights

Get exclusive datasets: t.co/jm9Zv6HoFi

#MERFISH t.co/8nOr05kYGp

🔦 #MERFISH 2.0 enables high-resolution spatial transcriptomics, even in challenging fixed frozen PDAC tissue.

🔬 Through Vizgen Lab Services, Marco Genua (Fondazione Telethon) mapped the tumor microenvironment, overcoming RNA quality challenges.

🔗 hubs.ly/Q038VZgB0

#Spatialbiology’s new era is here with MERFISH 2.0.

From Surface Structures to Subcellular Depths, #MERFISH 2.0 redefines #spatialtranscriptomics by further advancing the proven & trusted MERFISH chemistry.

🔍Explore real-world data & customer stories: hubs.ly/Q02Z870V0

A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver Reconstructing gene expression atlases for human tissues is challenging due to limited access to healthy samples from live donors. Neurologically deceased donors often show ischemic changes, while tis...

🌟 Groundbreaking research maps unique gene expression in human liver using #MERSCOPE and #MERFISH, unveiling key insights into liver function and early steatosis. This spatial atlas sets a new standard for understanding liver health and disease

#MERFISH #MERSCOPE

www.biorxiv.org/content/10.1...

🔬 Explore the latest breakthroughs in spatial genomics with the newly updated Vizgen Webinar Playlist on YouTube!

Watch now to hear directly from experts leveraging #MERFISH & the MERSCOPE® Platform to address the latest challenges in spatial biology: t.co/yiuoZ8Fkkw

Highly multiplexed spatial transcriptomics in bacteria Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

🌟 Bacterial-MERFISH revolutionizes microbiology! Profiles thousands of genes in single cells, revealing spatial gene expression. Unlocks insights into antibiotic resistance and gut health. 🧬✨

#MERFISH #BacterialTranscriptomics #Microbiology

www.science.org/doi/10.1126/...

Long-range genomic loci stochastically assemble into combinatorial forms of chromosome skeleton One fundamental yet open question is how eukaryotic chromosomes fold into segregated territories, a process essential for gene transcription and cell fate. Through analyzing Hi-C and chromatin-tracing...

🧬 Chromosome Folding Insights! 🧬

Research using #MERFISH reveals stable, long-range chromosome loops over 100 Mb, driven by nucleation centers. This offers new understanding of chromatin organization and cellular function.

#Genomics #ChromosomeFolding #MERFISH

www.biorxiv.org/content/10.1...

Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution | Circulation Research BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterog...

🚀 New Insights into Endothelial Cell Development! 🧬

Thanks to #MERFISH spatial transcriptomics a team uncovered how tissue origin and vascular positioning shape blood vessel formation.

#SpatialTranscriptomics #MERFISH #SingleCell #VascularDevelopment #CRISPR

www.ahajournals.org/doi/10.1161/...

Expanded bacteria are then combined with #MERFISH to image large fractions of the transcriptome. Benchmarked in E. coli, bacterial-MERFISH is accurate across a large dynamic range, has high detection efficiency and low false positives, and can image 100k+ cells. 6/

Image-based approaches to spatial transcriptomics — like #MERFISH — allow the massively multiplexed imaging of individual mRNAs within single cells within intact tissue samples. As such they have offered many exciting insights into a wide variety of eukaryotic questions! 3/

G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration Boraas et al. identify that mRNAs and the stress granule RNA-binding protein G3BP1 form ribonucleoprotein (RNP) complexes at FAs. These RNPs regulate FA protein mobility and cell migration under norma...

G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration: Cell Reports www.cell.com/cell-reports...

#MERFISH #SpatialTranscriptomics #SpatialBiology #SingleCell #SubCellular #OnlyRealDotsCount

🌟 Transforming #SpatialGenomics Research!

Vizgen's #MERFISH technology makes groundbreaking discoveries in neuroscience, oncology, & more accessible to researchers worldwide. With 310+ publications (161 peer-reviewed), its global impact is undeniable.

Explore: hubs.ly/Q034jjc80

Finally joined Bluesky! Reposting our preprint on spatial single-cell analysis of human cortical development! We used #MERFISH to analyze 16 million cells, revealing surprisingly early prenatal specification of human cortical layers and areas. t.co/EzAgvJdvaw

Skin is no barrier to acquiring #SpatialTranscriptomics data with MERFISH 2.0. In an #FFPE mouse skin study, #MERFISH 2.0 greatly improved transcript detection efficiency, revealing hidden insights into tissue structure and gene expression. Ready to discover more? Learn more: hubs.ly/Q0335qrP0

Highly Multiplexed Spatial Transcriptomics in Bacteria Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

"Highly Multiplexed Spatial Transcriptomics in Bacteria": the authors combined 1000-fold volumetric expansion w/ #MERFISH to create bacterial-MERFISH...!! 😍

pmc.ncbi.nlm.nih.gov/articles/PMC...

#spatialtranscriptomics #science