Clinical development of cancer vaccines - Nature Medicine This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular p...

New Review on #CancerVaccines: John Haanen and colleagues highlight insights from recent clinical trials and discuss critical factors for optimization, with a focus on proxies for efficacy, #neoantigen selection, modular platforms and early intervention
www.nature.com/articles/s41...

📚Personalized #CancerVaccines
Personalized #neoantigen vaccines target tumor-specific mutations to trigger strong T-cell responses with lower autoimmunity risk. Enabled by #NGS, #AI, immunopeptidomics&mRNA/LNP, neoantigens are moving faster to the clinic. ow.ly/QYZv50YbyYK

A research team from the Chinese PLA General Hospital has published a comprehensive review in Cancer Biology & Medicine . The study highlights global clinical progress in using neoantigens-loaded DC vaccines.
#Neoantigen
Details: doi.org/10.20892/j.i...

Computational neoantigen prediction for cancer immunotherapy - Genes & Immunity Genes & Immunity - Computational neoantigen prediction for cancer immunotherapy

🔥 #Review #alert
#Computational #neoantigen #prediction for #cancer #immunotherapy

#Genes & #immunity @springernature.com
www.nature.com/articles/s41...

A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma A personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses an...

A personalized neoantigen vaccine + Montanide/poly-ICLC/ipilimumab reshapes the T cell landscape in melanoma patients:
- Strong CD8+ responses
- TCR repertoires expanded beyond anti–PD-1
- Vaccine-specific TILs identified post-treatment

www.cell.com/cell/abstrac...?
#Neoantigen #Melanoma #Tcells

Synapse: Your Connection to our MSK Authors
Meet: Anna Mary Varghese @AnnaVarghese4

Research Focus: Medicine; Associate Attending

synapse.mskcc.org/synapse/work...

#PancreaticCancer #Immunotherapy #CancerVaccine #Neoantigen #RNAVaccine #CD8TCells #CancerResearch #BreakthroughScience

💥#TIMO2025 Great line-up of #immunotherapy experts/I talked #Cancer #antigens & #DarkGenome-derived #DarkMatter/ IMO: Recent studies explain why combination #immunotherapy with #personalized #neoantigen #vaccines are SUBOPTIMAL. See www.nature.com/articles/s43... www.science.org/doi/10.1126/...

This study reviews the therapeutic potential of personalized neoantigen vaccines in combination treatment strategies for renal cell carcinoma. Read more
doi.org/10.59717/j.x...
#Medicine #neoantigen #CancerTreatment #TIC2025

A modular, Galaxy-based immunopeptidogenomic (iPepGen) analysis pipeline for discovery, verification, and prioritization of candidate cancer neoantigen peptides Background Characterizing peptide antigens, processed from tumor-specific proteoforms, and bound to the major histocompatibility complex, is critical for immuno-oncology research. Next-generation sequ...

From @biorxivpreprint.bsky.social | A modular, Galaxy-based immunopeptidogenomic (iPepGen) analysis #pipeline for discovery, verification, and prioritization of candidate #cancer #neoantigen #peptides | #UseGalaxy #Bioinformatics #Proteomics #OpenScience 🧬 🖥️ 🧪 🔓
⬇️
www.biorxiv.org/content/10.1...

Generalization of neoantigen-based tumor vaccine by delivering peptide-MHC complex via oncolytic virus | EMBO Molecular Medicine imageimageOncolytic adenovirus was engineered for the forced ectopic delivery of peptide-MHC ligand of T cell receptors (TCRs) to expand the universality and therapeutic efficacy of neoantigen vaccine...

Making tumors visible again. Oncolytic virus co-expressing neoantigens and MHC forces tumors to display neoantigen-MHC on their surface. This allows effective T cell recognition and #anti-tumor response, irrespective of the endogenous #neoantigen expression.

www.embopress.org/doi/full/10....

Neoantigen vaccine sparks powerful immune defense against kidney cancer A personalized neoantigen cancer vaccine generated strong immune responses in renal cell carcinoma patients, leading to long-lasting T cell expansion and no disease recurrence after 40 months.

Neoantigen vaccine sparks powerful immune defense against kidney cancer 💉🔬🛡️ www.news-medical.net/news/2025020... #Cancer #Vaccine #Neoantigen #Immunotherapy #KidneyCancer #PrecisionMedicine #TCell #Medical #CancerResearch #Oncology @natureportfolio.nature.com

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-nega...

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients 🧬💉✨ www.news-medical.net/news/2024111... #Cancer #TripleNegativeBreastCancer #Immunotherapy #Neoantigen #Vaccine #PrecisionMedicine #ClinicalTrial #DNA #Oncology