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We worked with the amazing Carine Wouters and clinicians across Europe to collect samples for a #systemsimmunology analysis together with the Humblet-Baron lab at @kuleuvenuniversity.bsky.social. Critically, we we able to access samples at the point of diagnosis, many still untreated.

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Even among healthy people, immune systems operate at different baseline levels.

In our new Cell paper, we show that these immune states are stable over time and are associated with the gut microbiome. 🧵
@cp-cell.bsky.social
#Immunology #SystemsImmunology

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Kicking off the #KSAutoImmune26 with a sunny ski already 🎿
@keystonesymposia.bsky.social ! Look forward to great discussion on autoimmunity with folks at the conference! My lab fanzhanglab.org works on #SystemsImmunology
DM me if you'd like to ski together in the afternoons ⛰

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From Systems Immunology to Immunoengineering | Keystone Symposia Join us at the Keystone Symposia on From Systems Immunology to Immunoengineering, January 2026, in Vancouver, with field leaders!

Explore emerging research with field leaders @keystonesymposia.bsky.social #SystemsImmunology to #Immunoengineering, this January in Vancouver! keysym.us/KSSysImmune26 #KSSysImmune26 hubs.la/Q03VtR690

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Solo markers were interesting but combining gene SNPs and plasma metabolite data showed predictions for severe #COVID. That's why we study the whole #SystemsImmunology #BigScience #Teamwork

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ICF syndrome: An epigenetic paradigm of primary immunodeficiencies. New review from Ricardo Martins-Ferreira and Esteban Ballestar @eballestar.bsky.social @carrerasijc.bsky.social: rupress.org/jhi/article/...

#InbornErrorsOfImmunity #SevereImmunodeficiencies #BcellDeficiencies #SystemsImmunology

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LinkedIn This link will take you to a page that’s not on LinkedIn

Doctoral (PhD) Position – Spatial Transcriptomics, Bioinformatics & Mucosal Immunology

📍 Karolinska Institutet, Sweden

🗓️ Deadline: Dec 10, 2025

kidoktorand.varbi.com/what:job/job...

#SpatialTranscriptomics #Bioinformatics #MucosalImmunology
#SingleCellOmics #IBDResearch
#SystemsImmunology

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A systems immunology analysis of Alzheimer's disease reveals an age‐ and environmental exposure‐independent disturbance in B cell maturation INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal mode...

Our new study on #systemsimmunology analysis of #Alzheimers patients is out now at @alzdemjournals.bsky.social!

This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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We now have 10 global scientific partners who will collaborate to decode the human immunome using big data and #machinelearning, making this the largest collaboration in #systemsimmunology in history.

@tsanglab.bsky.social @immunome.bsky.social
#humanimmunology #immunesetpoint #immunehealth

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Big news: We've announced the largest #systemsimmunology collaboration in history! Ten world-class research institutes are joining @immunome.bsky.social in a pioneering plan to understand human immune response variability.

www.humanimmunomeproject.org/news/human-i...

@tsanglab.bsky.social

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Preprint alert📜: How do lifetime viral exposures shape our immune system response to future infections? 🦠🧬

We explore this question in our new preprint, led by postdoc
Chad Hogan.

biorxiv.org/content/10.1...

#SystemsImmunology #Immunology #Virology #Infection #HostResponse

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Decoding sex differences in human immunity through systems immunology Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

‼️Our first review is out‼️

Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE

We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments.

Excellent work by @resabut.bsky.social & Tianze Cao!

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Join us for this exciting webinar tomorrow, 24th June 2025 at 14h00 CEST!

@resabut.bsky.social PhD student in my #SystemsImmunology will be speaking ;)

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A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...

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A systems immunology analysis of Alzheimer's disease reveals an age- and environmental exposure-independent disturbance in B cell maturation
Feng, Y., Humblet-Baron, S. et al.
Paper
Details
#SystemsImmunology #AlzheimersDisease #BCellMaturationResearch

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Tianze Cao, PhD student in my #SystemsImmunology lab, had an excellent presentation on how #Metabolic and #Reproductive factors impact the #ImmuneSystem in #PCOS at the #AE_PCOS_Update_Meeting at #ECE2025 @aepcossociety.bsky.social

Exciting collaborative work with @elisabetsv.bsky.social

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#systemsimmunology #AI #machinelearning #humanimmunology #immunevariation #immunesetpoint #immunehealth #humanimmunomeproject

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I think the reason I like #systemsimmunology #cshlsysimm is because network diagrams are so pretty.

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Systems-level immunomonitoring in children with solid tumors to enable precision medicine In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunothera...

How do immune responses vary across different childhood ages and tumor types?

A crucial study from @petterbrodin.bsky.social’s lab freshly baked on #SystemsImmunology, advancing precision medicine in pediatric diseases!

www.cell.com/cell/fulltex...

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Lab just pressed submit on our first manuscript! 🎉🥂 #newPI #SystemsImmunology #SexDifferencesHumanImmunity

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‼️‼️

Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden

More info on how to apply below (please RT)

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We worked with the #ImmunAID Consortium to collect patient samples from across Europe for a #systemsimmunology analysis together with the Humblet-Baron lab at @kuleuvenuniversity.bsky.social.

Critically, we we able to access treatment-naïve samples, as biologics confound #immunology analysis

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Curious? Check out "Organismal mucosal immunology: A perspective through the eyes of game theory" to see how this framework can inspire new approaches to research. 7/7

#GameTheory #Immunology #SystemsBiology #SystemsImmunology #MucosalImmunology

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http://spr.ly/6014m7GFk

Grateful to #BU for supporting our groundbreaking research at the Atomic Lab! ⚛️ We're using the power of #AI to develop innovative #vaccines for #pandemic #viruses. Check out this fun video to see what we're up to: t.co/NKe0Jrzg0l #ScienceRocks #SystemsImmunology

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Are you an #Immunologist?

Do you have expertise in #MolecularBiology and #CellBiology?

Do you want to investigate why men and women mount immune responses differently?

Join us as a #PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Immunity!

See more below (please RT)

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Modeling how antibody responses may determine the efficacy of COVID-19 vaccines - Nature Computational Science A multiscale model is presented to quantitatively predict COVID-19 vaccine efficacies by describing the generation, activity and diversity of neutralizing antibodies.

4/n switching immunological gears, Dixit next addresses the high variance in neutralising properties of anti-SARS-COV2 antibodies in people who have recently cleared COVID infection. #ICSB2024 #systemsImmunology www.nature.com/articles/s43...

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2/n the interesting thing about this model is that additional factors- such as innate cytokines - can shift the boundaries of the model, but not the 3-state outcomes.
#ICSB2024 #SystemsImmunology

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Join our #SystemsImmunology Lab (Lund University, Sweden) as a #Postdoctoral Fellow!

🔬 Project: To investigate sex hormone regulation of human immune function using CRISPR, transcriptomics, and immunophenotyping. Fully funded 2-year position (more info attached).

🗓️ Apply by Jan 6, 2025

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What to expect if you follow me?
I post a few times a week and repost relevant stuff from others on the following themes:
#SystemsBiology
#HumanMicrobiome
#ImmuneHealth
#SpaceHealth
#HumanImmunology
#Autoimmunity
#Immunomodulation
#SystemsImmunology

#Mentorship
#InclusiveMentorship
#scienceCulture

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Center for Systems & Engineering Immunology The Yale Center for Systems and Engineering Immunology (CSEI) at the Yale University School of Medicine (YSM) brings together Yale faculty and trainees from

Hello Bluesky Community! The Yale Center for Systems and Engineering Immunology is here. Excited to join and contribute to the conversation!

Learn more about us at: medicine.yale.edu/systems-engi...

#YaleCSEI #systemsimmunology #immunology
@yalecsei.bsky.social

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