StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍

Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠

Learn more 🍁 https://bit.ly/2II2Jeg

#AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1

StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍

Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠

Learn more 🍁 https://bit.ly/2II2Jeg

#AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1

StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍

Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠

Learn more 🍁 https://bit.ly/2II2Jeg

#AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1

The image contains four graphs related to mismatch models for Penn Antiamyloid Therapy Monitoring (ATM). Graph A shows measured vs predicted CDR-SB score with a trend line. B shows time from tau positivity relative to plasma p-tau217. C predicts change in CDR-SB score over time, D displays expected change in CDR-SB score over 18 months of treatment; Resilient, Canonical and Vulnerable groups are compared.

Individuals with #AlzheimerDisease showing greater clinical impairment than predicted by tau burden are more likely to have copathology, including #TDP43 and #AlphaSynuclein, and experience faster decline.

bit.ly/3ZVKB8a

Headline announcing new research: Antibodies developed to target TDP-43 clumps in ALS, potentially reducing toxic proteins while preserving healthy ones.

New ALS research: https://bit.ly/4sGzahU

Scientists are studying antibodies designed to bind only the harmful form of the TDP 43 protein linked to most ALS cases while leaving the healthy version untouched.

#ALS #ALSResearch #NeurodegenerativeDisease #TDP43 #ALSNewsToday #Bionews

Product Citation 🎐

Investigators utilized StressMarq's Phosphoserine Antibody to reveal that insulin signaling can shift #tau isoform expression & alter #TDP43 localization in neurons, in #neurodegenerative disease mechanisms.

Paper 🌜 https://bit.ly/4qy2uVZ
Product ⭐ https://bit.ly/499bjyk

CLARiTI Research Portfolio Welcome to the website for CLARiTI's research portfolio projects, including our new TDP43 Summit. This page features information on events and initiatives from the CLARiTI team at University of Wiscon...

📣Call for Abstracts: 2026 TDP43 Summit
Researchers are invited to submit abstracts featuring new and emerging data on #TDP43.
🔗uwmadison.co1.qualtrics.com/jfe/form/SV_06NGAuRlTgGr...

Learn more: sites.google.com/wisc.edu/cla...

RSVP: uwmadison.co1.qualtrics.com/jfe/form/SV_...

#CLARiTI

Figure 4. Graphs show mismatch models in Penn Antiamyloid Therapy Monitoring(ATM) cohort. Graph A is classification, B is time calculation from tau positivity. Graphs C and D show change in CDR-SB score over treatment time and after 18 months.

Individuals with #AlzheimerDisease showing greater clinical impairment than predicted by tau burden are more likely to have copathology, including #TDP43 and #AlphaSynuclein, and experience faster decline. ja.ma/3KLq5Du

TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins - Nature Cell Biology Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with F-actin-bound actin-binding proteins.

Product Citation 🌟

StressMarq's #HSP27 Antibody was used for proximity labeling-mass spectrometry @ucsandiego.bsky.social, which found that cellular stress induces BAG3-mediated #TDP43 inclusion formation.

Paper 💫 https://bit.ly/4ojR5HJ
Product 🌌 https://bit.ly/3M2EfQZ

Graphic titled "ALS News" featuring a megaphone icon. The text discusses two companies collaborating on TDP-43 protein molecules linked to ALS and dementia. The challenge is relocating TDP-43 without hindering its function, aiming to prevent cell dysfunction and disease progression.

Explore new ALS research: https://bit.ly/3JHDVGx

Two companies are partnering on a potential new approach that aims to address TDP-43, a toxic protein involved in most ALS cases and many cases of FTD.

#ALSNewsToday #ALSResearch #FTD #TDP43 #NeurodegenerativeDisease #ALSCommunity #Bionews

Plasma TDP-43 is a potential biomarker for advanced limbic-predominant age-related TDP-43 encephalopathy neuropathologic change - Molecular Neurodegeneration

#Plasma TDP-43 is a potential #biomarker for advanced limbic-predominant age-related #TDP43 encephalopathy neuropathologic change

Jijing Wang, Julie A. Schneider, David A. Bennett...& Hyun-Sik Yang @harvardmed.bsky.social

molecularneurodegeneration.biomedcentral.com/articles/10....

Sanders-Brown was well represented at the 𝟐𝟎𝟐𝟓 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥-𝐓𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
@ukresearch.bsky.social @selenicalab.bsky.social @macauleylab.bsky.social #research #TDP43 #sleepdisruption #astrocytes

Magnifying glass examines a neuron, highlighting TDP-43 abnormalities possibly linked to motor neuron loss in ALS.

New Study: https://bit.ly/4ooYDKo

Researchers are taking a close look at how the TDP-43 protein shifts inside motor neurons. In most people living with ALS, this protein moves out of the nucleus and into the surrounding cell space.

#ALS #Bionews #ALSNewsToday #ALSResearch #TDP43 #ALSCommunity

TDP-43 Hexamutant Monomers (SPR-522) Order TDP-43 Hexamutant Monomers (SPR-522) from StressMarq. High-quality reagents for neurodegenerative disease research.

💡 New Product! #TDP43 aggregation & cross-seeding is implicated in multiple #neurodegenerative diseases, including #ALS & frontotemporal #dementia. StressMarq's new TDP-43 Hexamutant (W→S) Monomers feature dramatically reduced aggregation propensity.

🔭 Product Details: https://bit.ly/45BpeNg

📫 The September edition of 'What's New at StressMarq?' is here! Read about our new #TDP43 Hexamutant Monomers, learn more about an exciting recent collaborative study, and stay up to date with our upcoming products & latest blog posts.

🔗 Read it here: https://bit.ly/47PsKoO

TDP-43 & Neurodegeneration: Unraveling Protein Aggregation Explore the role of TDP-43 in ALS, FTD, and Alzheimer’s, and its potential as a therapeutic target in neurodegenerative disease research.

Misfolding & aggregation of #TDP43 is linked to #ALS, #FTD, and #Alzheimers disease. Explore its role in driving #neurodegeneration & potential as a therapeutic target, and discover StressMarq's innovative TDP-43 Hexamutant (W→S) Monomers.

Read the StressMarq blog 📚 https://bit.ly/3HN4lpq

TDP-43 Hexamutant Monomers (SPR-522) Order TDP-43 Hexamutant Monomers (SPR-522) from StressMarq. High-quality reagents for neurodegenerative disease research.

💡 New Product! #TDP43 aggregation & cross-seeding is implicated in multiple #neurodegenerative diseases, including #ALS & frontotemporal #dementia. StressMarq's new TDP-43 Hexamutant (W→S) Monomers feature dramatically reduced aggregation propensity.

🔭 Product Details: https://bit.ly/45BpeNg

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes - Molecular Neurodegeneration Background In the last decade, the importance of DNA methylation in the functioning of the central nervous system has been highlighted through associations between methylation changes and differential...

Methylome analysis of #FTLD patients with #TDP43 pathology identifies #epigenetic signatures specific to pathological subtypes

Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman...Rosa Rademakers @viblifesciences.bsky.social

molecularneurodegeneration.biomedcentral.com/articles/10....

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

#ExtracellularVesicles in #TDP43 proteinopathies: pathogenesis and #biomarker potential

Elizabeth R. Dellar @lizziedellar.bsky.social Lara Nikel, Stephanie Fowler...Alexander G. Thompson #exosome #ALS #FTD

molecularneurodegeneration.biomedcentral.com/articles/10....

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

Very pleased to share our review in @molneurodegen.bsky.social, assessing evidence for #ExtracellularVesicle associated #TDP43. We highlight knowledge gaps relating to its biomarker usage and possible involvement in seeding of templated aggregation in #ALS, #FTD and #LATE.
doi.org/10.1186/s130...

RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights - Molecular Neurodegeneration Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative disorders with overlapping clinical, genetic and pathological features. A large body of evidence...

'RNA-binding proteins in #ALS and #FTD: from pathogenic mechanisms to therapeutic insights'

Jens Rummens & Sandrine Da Cruz @cbdresearch.bsky.social
#FrontotemporalDementia #TDP43

molecularneurodegeneration.biomedcentral.com/articles/10....

🧠 The ABC of TDP-43
TDP-43 doesn’t just misfold, it gets creative! Diana Arseni (MRC-LMB) shows how this key protein forms amyloid filaments with disease-specific folds. The reason? Join us at LMB-IP 2025 to find all about it.
#TDP43 #CryoEM #BrainResearch #LMBIP2025 #Neurodegeneration

Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates - Nature Communications Here, the authors implement molecular dynamics simulations to model ATP-driven enzymatic reactions, revealing how the enzyme CK1δ phosphorylates condensates of the neurodegeneration linked protein TDP...

🚨Publication alert🚨
"Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates" by Emanuele Zippo, @lstelzl.bsky.social, @dormannlab.bsky.social & Thomas Speck. Congratulations!!
📄 www.nature.com/articles/s41...
#TDP43 #CK1δ #ALS #biophysics #proteincondensates

Proteomics Analysis of the TDP‐43 Interactome in Cellular Models of ALS Pathogenesis Cytoplasmic aggregation and nuclear depletion of TAR DNA-binding protein 43 (TDP-43) is a hallmark pathology of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), front...

Proteomics Analysis of the TDP‐43 Interactome in Cellular Models of ALS Pathogenesis - Cheng - 2025 - Journal of Neurochemistry - Wiley Online Library #mnd #als #tdp43 #interactome @mndaus-research.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...

Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration - Molecular Neurodegeneration Increased phosphorylation of TDP-43 is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the reg...

'Molecular mechanisms and consequences of #TDP43 phosphorylation in #neurodegeneration'

Elise A. Kellett, Adekunle T. Bademosi, Adam K. Walker #ALS #FTD

bit.ly/4j0Bmee

A protein link between brain diseases and leaky blood-brain barrier – BioNews Central Mutations in the TARDBP gene that reduce TDP-43 protein levels also impair the endothelial cells lining the blood vessels in the brain, which play a vital role in maintaining the blood-brain barrier—a protective shield that prevents harmful substance

#Mutations in the TARDBP gene that lower #TDP43 protein levels damage #brain #BloodVessel #EndothelialCells, disrupting the #BloodBrainBarrier and contributing to diseases like #Alzheimers, #FrontotemporalDementia, and #ALS.

TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis - Molecular Neurodegeneration Background In recent years, the seed amplification assay (SAA) has enabled the identification of pathological TDP-43 in the cerebrospinal fluid (CSF) and olfactory mucosa (OM) of patients with genetic...

' #TDP43 seeding activity in the #olfactory mucosa of patients with #AmyotrophicLateralSclerosis'

Maria Vizziello, Ilaria Linda Dellarole...Eleonora Dalla Bella & Fabio Moda

molecularneurodegeneration.biomedcentral.com/articles/10....

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement - Molecular Neurodegeneration Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis. While research has focused on...

'Multi-region brain #transcriptomic analysis of #AmyotrophicLateralSclerosis reveals widespread RNA alterations and substantial cerebellum involvement'

Natalie Grima, Andrew N. Smith, Claire E. Shepherd...Kelly L. Williams #TDP43

molecularneurodegeneration.biomedcentral.com/articles/10....

🚨 New study in #NatureChemicalBiology!
#PROXIDRUGS researchers show linking #TDP43 to #SUMO sends it to PML nuclear bodies—preventing harmful aggregates under stress.
🧠 A key step toward potential small-molecule therapies for #ALS & related diseases.
@goetheuni.bsky.social #BMBF

An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics

www.biorxiv.org/content/10.1101/2024.03....

#neurodegeneration #TDP43