MPNs and Kidney Disease: An Underrecognized but Common Connection Some estimates suggest up to 80 percent of people with MPNs may have some form of kidney dysfunction. Despite this high prevalence, kidney disease has historically received little attention in MPN pat...

#ET #MPN #thrombocythemia #CKD
Brand new blog post.
Maybe it wasn’t the Anagrelide after all.
www.patientpower.info/news/myelopr...

Essential Thrombocythemia Can Prompt Nonarteritic Anterior Ischemic Optic Neuropathy Case report from SECO 2026 shows how a rare blood disorder can be an atypical cause of nonarteritic anterior ischemic optic neuropathy.

#SECO2026: Although atypical, nonarteritic anterior ischemic optic neuropathy (#NAION) can be caused by essential #Thrombocythemia,

Presented by Sharon Bisighini-Fiske, OD, FAAO, of the VA Medical Center in Newington, CT at the 2026 SECO International

Read more ➡️: https://bit.ly/4b3rGOb

Ropeginterferon Alfa-2b Under Review for Essential Thrombocythemia The FDA has accepted the supplemental Biologics License Application for ropeginterferon alfa-2b-njft for the treatment of adults with essential thrombocythemia.

The @fda.gov has accepted the supplemental Biologics License Application for ropeginterferon alfa-2b-njft for the treatment of adult patients with essential #thrombocythemia. From @medicalprofref.bsky.social.

https://bit.ly/4qwQuoj

New report from Zhou et al. (rupress.org/jem/article/...) provides important new insights into the genotype–phenotype correlation and the molecular pathogenesis of essential #thrombocythemia. Insights by Skoda and Silvennoinen: rupress.org/jem/article/...

#Hematopoiesis

New findings from Xiaohui Zhang, Bo Huang et al. not only elucidate the molecular mechanism of JAK2V617F essential #thrombocythemia but also provide a potential strategy for its treatment. rupress.org/jem/article/...

#Hematopoiesis

Heterozygous human JAK2V617F activates AhR to drive essential #thrombocythemia and promote #thrombosis, say Li Zhou, Dongxiao Wu, Xiaohui Zhang, Bo Huang and colleagues: rupress.org/jem/article/...

#Hematopoiesis

In @jem.org, Zhou et al. reveal that heterozygous JAK2V617F variant in megakaryocyte-erythroid progenitors drives essential #thrombocythemia via STAT1-IDO1-AhR-RUNX1, whereas the homozygous JAK2V617F variant promotes #polycythemia vera through the activation of STAT5. rupress.org/jem/article/...

Zhou et al. reveal that heterozygous JAK2V617F variant in megakaryocyte-erythroid progenitors drives essential #thrombocythemia via STAT1-IDO1-AhR-RUNX1, whereas the homozygous JAK2V617F variant promotes #polycythemia vera through the activation of STAT5. rupress.org/jem/article/...

Primary #Thrombocythemia, thrombosis treatment

1. Low risk population
Low-dose #aspirin, as a basic treatment, is used to reduce the risk of thrombosis

2. High risk population
#Hydroxyurea can inhibit excessive proliferation of platelets

Https://ja.ma/4hxjc3v

Review: Essential Thrombocythemia This narrative review summarizes current evidence on the pathophysiology, clinical presentation and diagnosis, risk stratification, and treatment of essential thrombocythemia.

persons with essential #thrombocythemia may be treated with low-dose aspirin, either alone or in combination with a cytoreductive drug such as hydroxyurea. @jama.com
jamanetwork.com/journals/jam...