The #GTPase #Npa3 plays a key role in RNA Pol II assembly & nuclear import. In a new study, Martín Mora-García et al. reveal crosstalk between Npa3 and #TORC1 signalling, suggesting involvement in translation initiation, TORC1 signaling, and #stress adaptation🧬

Read it here: tinyurl.com/bdau2mp2

New Drug Rapalink-1 Extends Yeast Lifespan by Targeting TORC1

Researchers found the experimental drug Rapalink-1 can extend the lifespan of fission yeast (Schizosaccharomyces pombe) by acting on TORC1, the growth‑regulating complex. getnews.me/new-drug-rapalink-1-exte... #rapalink1 #torc1 #aging

Vacuolar pH regulates #clathrin-mediated #endocytosis through #TORC1 signaling during replicative #aging, say Kenneth Gabriel Antenor, Mojca Mattiazzi Usaj et al. @torontometsci.bsky.social rupress.org/jcb/article/...

Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells - PubMed Previously, we identified a prolactin (PRL)-inducible gene encoding EDD E3 ubiquitin ligase in human breast cancer (BCa) cells. We reported that EDD binds the mTOR (TORC1)-associated α4 phosphoprotein...

EDD is a gene induced by PRL in human BCa cells, suggesting a link between hormonal signaling and cancer progression

pubmed.ncbi.nlm.nih.gov/31392083/

#TORC1 #apoptosis #breastcancer #prolactin

Absolutely thrilled to read this paper on how MORG1 limits TORC1 signaling! Fascinating insights into autophagy, revealing how WDR83 facilitates basal autophagy. Science at its best!

@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy