Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.
High-resolution insight into tumor evolution.
doi.org/10.1038/s413...
#ColonCancer #SingleCellSequencing #CancerGenomics #Metastasis #TRPS1 #TumorEvolution

🚨 New preprint!
We introduce PICTographPlus — a method to recover clone‑specific transcriptomes from bulk DNA + RNA sequencing (no single‑cell required!). 🧬💻
See bioRxiv 👉 www.biorxiv.org/cgi/content/...
@fertiglab.bsky.social @break-cancer.bsky.social
#CancerGenomics #TumorEvolution #Bioinformatics

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plastic...

#Review in #MedComm
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions doi.org/10.1002/mco2...

#DifferentiationTherapy #EpigeneticReprogramming #SpatiotemporalOmics #TherapyResistance #TumorEvolution #TME

A molecular systems view of aggressive cancers reveals signaling rewiring, metabolic stress responses, and adaptive survival programs.
#AggressiveCancer #CancerBiology #SignalingNetworks #TumorEvolution
www.nature.com/articles/s41...

📢 Early-career cancer researchers! Save $250 on registration for Spotlight on the Cancer Cell by Nov 25 (11:59pm MST). Hear from co-organizer Anwesha Dey 🎥 youtu.be/npXedgJvk5Q

Register: keysym.us/KSCancerCell26

#KSCancerCell26 #cancercell #tumorcell #cancerevolution #tumorevolution