Tyramine Intolerance: A Hidden Cause of Migraines and Blood Pressure Fluctuations At 45, Zoe thought she knew her body—until she was blindsided by sudden episodes of a racing heart and overwhelmi...
#cheese #diet #tyramine
Origin | Interest | Match
New post up about the basics of following a low-tyramine diet: open.substack.com/pub/goodbyec... #substack #tyramine #NEISvoid #chronicmigraine #hypertension #foodintolerance
Fantastic talk from the man who made flies sexy - Marc Freeman. Check out this fantastic story on bioRxiv
www.biorxiv.org/content/10.1...
props to Kevin Guttenplan and coauthors!
#noradrenaline #tyramine #astrocytes #neuroscience
Top: A one-minute recording of tyramine-induced intestinal Ca2+ waves in a Caenorhabditis elegans nematode. The GCaMP channel is pseudo-colored by time. Bottom: A model of the proposed mechanism; the escape neurohormone tyramine activates TYRA-3 in the intestine, elevating calcium levels, likely through IP3-dependent mechanisms involving ITR-1. Activation of TYRA-3 triggers the intestinal release of INS-3, which systemically activates DAF-2. DAF-2 activation results in the phosphorylation of DAF-16, preventing its nuclear translocation and inhibiting the transcription of cytoprotective genes.
The flight response in #worms comes at a cost. This study defines a brain-gut pathway mediating this adaptive tradeoff, wherein #tyramine stimulates INS-3 expression in the intestine, leading to systemic activation of #insulin signaling & reduced stress resistance 🧪 @plosbiology.org plos.io/42Ek3Lz
Top: A one-minute recording of tyramine-induced intestinal Ca2+ waves in a Caenorhabditis elegans nematode. The GCaMP channel is pseudo-colored by time. Bottom: A model of the proposed mechanism; the escape neurohormone tyramine activates TYRA-3 in the intestine, elevating calcium levels, likely through IP3-dependent mechanisms involving ITR-1. Activation of TYRA-3 triggers the intestinal release of INS-3, which systemically activates DAF-2. DAF-2 activation results in the phosphorylation of DAF-16, preventing its nuclear translocation and inhibiting the transcription of cytoprotective genes.
The flight response in #worms comes at a cost. This study defines a brain-gut pathway mediating this adaptive tradeoff, wherein #tyramine stimulates INS-3 expression in the intestine, leading to systemic activation of #insulin signaling & reduced stress resistance 🧪 @plosbiology.org plos.io/42Ek3Lz
Top: A one-minute recording of tyramine-induced intestinal Ca2+ waves in a Caenorhabditis elegans nematode. The GCaMP channel is pseudo-colored by time. Bottom: A model of the proposed mechanism; the escape neurohormone tyramine activates TYRA-3 in the intestine, elevating calcium levels, likely through IP3-dependent mechanisms involving ITR-1. Activation of TYRA-3 triggers the intestinal release of INS-3, which systemically activates DAF-2. DAF-2 activation results in the phosphorylation of DAF-16, preventing its nuclear translocation and inhibiting the transcription of cytoprotective genes.
The flight response in #worms comes at a cost. This study defines a brain-gut pathway mediating this adaptive tradeoff, wherein #tyramine stimulates INS-3 expression in the intestine, leading to systemic activation of #insulin signaling & reduced stress resistance 🧪 @plosbiology.org plos.io/42Ek3Lz
