Excellent talk by our @unidue-zmb.bsky.social colleague Pinki Galhot from @hemmo-lab.bsky.social @imprs-lm.bsky.social 👏 #MK2026 @gbmev.bsky.social

Finally celebrating Matthi‘s paper publication on p97‘s accessory adapters. Great job. doi.org/10.1126/scia...

The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.

VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...

Thrilled to be hosting Brenda Schulman, @aakritijain.bsky.social, @crismayorruiz.bsky.social @davidbalchin.bsky.social, @hemmo-lab.bsky.social, Ian Ganley, @kirsteinlab.bsky.social, Juliette Fedry, @elliottlab.bsky.social & @plantophagy.bsky.social - BIG THANKS for accepting the invitation 🙏

The Meyer lab Xmas dinner once again with traditional German skittle competition. We won! 🎳

Fantastic and productive meeting with the labs of Tamotsu Yoshimori, Shuhei Nakamura, Akiko Kuma at #Osaka University. Discussing perspectives of #microautophagy in th #lysosome regeneration after damage. Thanks so much for hosting me.

Meeting new and old friends at the JPS conference in Kyoto, Japan. Presented our newest data on the #Lysosome Damage Response. #ATXN3 Thanks to the organizers.

ATG9A assists lysosome membrane repair. Our preview on the Tooze lab’s paper is now online and free thru this link: authors.elsevier.com/a/1lzTz5Sx5g...

Excellent thesis defense by Pinki Gahlot concluding brillant work on a sensor module, SPG20-ITCH that detects lipid packing defects in the limiting membrane of permeabilized #lysosomes and initiates #lysophagy.

ATXN3-p97 facilitates #lysosomal restoration after damage by deubiquitinating LAMP2 and targeting it for degradation via microautophagy
Hemmo Meyer and coworkers @hemmo-lab.bsky.social
www.embopress.org/doi/full/10....

Fun at the lab outing

A successful @crc1430.bsky.social PhD Career Day is behind us!
Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights.
We enjoyed a day full of career advice, inspiring talks, and great networking over dinner.
#PhDCareers #JobsAfterPhD

Thank you again Chuna Choudhary from @choudharylabcpr.bsky.social at CPR in Copenhagen for visiting us last week for an exiting CRC1430 @crc1430.bsky.social seminar and for discussing the systems properties of ubiquitination www.cell.com/cell/fulltex...

We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin

Concluding a productive @crc1430.bsky.social retreat with our PIs, exploring the 'Molecular Mechanisms of Cell State Transitions'. Thanks to everyone for the engaging discussions and collaborative efforts that made this retreat truly impactful! #ScienceInAction #ResearchCollaboration

Can’t believe the fantastic Dana Branzei has joined our faculty in Essen and the #CRC1430! Esteemed expert in DNA replication and repair, Humboldt-Professor, and zabaione connaisseuse. #UDE

Another excellent Frankfurt meeting #fcqc2025 on cellular quality control. Fantastic speaker lineup, discussions and hospitality. Thx to the organizers. #ubiquitin #autophagy fcqc.de

Great visit in Kiel Biochemistry with Elmar Wolf, Paul Saftig, M. Damme, M. Voß. Talking exciting (lysosome) science at the beautiful Kiel Fjord.

New VCP/p97 review article. Report on the excellent VCP meeting at CalTech last year and great overview on VCP and VCP disease.
doi.org/10.1016/j.nb...

Different ways to target substrate proteins to the VCP/p97 unfolding machine: www.frontiersin.org/journals/mol...

Our review on the lysosomal damage response is Open Access: www.annualreviews.org/content/jour...