CD-CODE v2.2 RELEASE is live🤩

Our #database grew:
💡10 new #condensates
💡639 new #condensate - #protein connections
💡107 new c-mods
💡10 new #condensatopathies

🟣Find your favorite condensate cd-code.org and 👀see more details about the #release: cd-code.org/release

#cdcode #IDP #RBP #DatabaseUpdate

Two-panel calibration plot (two benchmark dimer datasets) comparing predicted interchain contact-probability bins (x-axis) with the observed fraction of native interfacial contacts (y-axis). Points follow the diagonal, indicating close agreement between predicted probabilities and true interface-contact fractions.

My first manuscript in MPI colours! With @tothpetroczylab.bsky.social, we show that AlphaFold PAE-derived contact probabilities are well calibrated to the fraction of true interface contacts across experimentally determined protein dimers.

www.biorxiv.org/content/10.6...

two dogs are riding a sled down a snow covered road . ALT: two dogs are riding a sled down a snow covered road .

Our pre-holiday database update is live! 🎄CD-CODE v2.1 is here.
Adding
🎁 11 new condensates
🎁 276 new proteins
We now track a total of 13,983 condensate-protein relationships, plus 253 c-mods and 113 condensatopathies.

Dive into the data and see more details about the release: cd-code.org/release

Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social

💡With a #relational structure, programmatic access #API and improved search capabilities, CD-CODE 2.0 easily integrates into #datascience and digital #biology workflows, broadening its versatility and creating connections between condensate biology and #therapeutic development.
🔗 cd-code.org

CD-CODE is a great example of an interdisciplinary teamwork between computational and experimental biologists and software engineers! #Thankyou to all the authors of @tothpetroczylab.bsky.social, the biomolecular condensate community of @mpi-cbg.de, @hymanlab.bsky.social, and Dewpoint Therapeutics!

puzzle pieces are connected to represent CD-CODE database concept. landscape orientation (4 puzzle pieces top row, 5 puzzle pieces lower row). Top row: puzzles representing applicability, API, infectious condensate with logo representing pathogen cell and condensate, condensatopathies with a stethoscope logo, text: CD-CODE CrowDSourcing Condensate Database and Encyclopedia. Bottom tow: puzzles representing community, CD-CODE logo, Biomolecualr condensates with logos for species (human, frog, mouse), c-mods with chemical compound logo, DNA, proteins, RNA minimalistic logos.

CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...

The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩

Big #thankyou to all the participants from
@hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜

☀️summer is here -
and so is CD-CODE v1.10 release!🤩

💡CD-CODE has now 719 manually curated #condensates (and ~40% are #human associated!)

💡Check out new #condensates and updated #protein - condensate connections at cd-code.org

#Bioinformatics #DatabaseUpdate #IDR #RNP #RBP #cdcode

😊 I had the pleasure to turn this exciting @cellpress.bsky.social paper into a video-abstract. Check it out!

youtu.be/0REvwcuOao8

Thanks to the authors for writing the script and to @hymanlab.bsky.social and to @mpi-cbg.de for sharing it!

UniProt UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.

We're really excited that CD-CODE is now cross-referenced by #UniProt and has already been included in the latest release: www.uniprot.org/release-note...

Spreading knowledge about #biomolecular #condensates 🥳

@ebi.embl.org @sib.swiss @mpi-cbg.de @tothpetroczylab.bsky.social @hymanlab.bsky.social

logo with a shark

The @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...

🚀 Exciting Opportunity 🚀
Do you have a passion for structural biology?

We're hiring at @PDBeurope! 🌟

Apply now to help annotate biological data 💻 🔬
🔗 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Closing date: April 6, 2025

#JobOpening #StructuralBiology #Bioinformatics #ScienceJobs #Hiring

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🍃CD-CODE update v1.09 is here!🍃

👀Check out the new #biomolecular #condensates at cd-code.org
👀We're continuing to update #Protein - #condensate connections and resolve issues!

Join us to share your #condensate #expertise as a contributor: cd-code.org/signup

#Bioinformatics #DatabaseUpdate #IDR

visual for the job ad with pipettes in the background

The research group of Agnes Toth-Petroczy @tothpetroczylab.bsky.social is looking for an experimental Postdoc (m/f/d) in protein evolution of biomolecular condensates. Apply now! careers.mpi-cbg.de/jobs/5312959...

Follow our research group leaders @mpicbg.bsky.social to get updates on their science activities! go.bsky.app/3gGPAgM

Get news from science institutes and universities, located in Dresden, Germany. Please add missing ones in the comments. go.bsky.app/BgRhagp

We are looking for a Student Helper in International Culture and Policies. Apply now and join us! careers.mpi-cbg.de/jobs/5276094...

PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms - Nature Communications Here the authors report PICNIC (Proteins Involved in CoNdensates In Cells), a machine learning algorithm that predicts approximately 40–60% of proteins form condensates in various organisms, showing n...

Our PICNIC tool predicts condensate-proteins regardless of their structural disorder across organisms @naturecomms.bsky.social. Congratulations to @annaha-poetry-art.bsky.social for developing the algorithm and to Hari
@hymanlab.bsky.social for the experiments! www.nature.com/articles/s41...

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✨Winter CD-CODE update to v1.08!✨

❄️ New #biomolecular #condensates added (total ⚪: 680)
❄️ #Protein - #condensate connections updated
❄️ Species attributes fixed 🤩

👀Check the current version here: cd-code.org
Join us to become a contributor: cd-code.org/signup

#DatabaseUpdate #Bioinformatics #IDR

Congratulations, Agnes! 🤩

Flyer for the course Keeping up with the interactome - How IDPs work including a list of speakers: Professor Tanja Mittag, St Jude Children’s Hospital, Memphis, US Professor Kresten Lindorff-Larsen, BIO, SCIENCE, UCPH Professor Ylva Ivarsson, Uppsala University, Sweden Dr. Michael Wehr, Systasy Bioscience, Munich, Germany Professor Zsuzsanna Dostztányi, Eötvös Loránd University, Hungary Professor Kristian Strømgaard, HEALTH, UCPH Professor Stefano Gianni, Sprienza University of Rome, Italy Professor Per Jemth, Uppsala University, Sweden Dr. Franziska Schöppe, Novo Nordisk A/S, Denmark Professor Benjamin Schuler, University of Zurich, Switzerland Professor Alfonse De Simone, University of Naples, Italy Dr. Malene Ringkjøbing Jensen, CNRS, Grenoble, France Alleyn Plowright, Chief Scientific Officer, Pangea Bio, London UK Professor Birthe B. Kragelund, BIO, SCIENCE, UCPH

If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.

Details: phdcourses.ku.dk/DetailKursus...

Hello Bluesky! We're thrilled to announce an open PhD position on exploring controlling condensate membrane attachment and exocytosis! Collaborate across Europe in the ComeInCell EU network. Apply now! Details: www.comeincell.org & www.ru.nl/en/working-a...

Thank you, @rnadavid.bsky.social for compiling this starter pack 🤩
Join the condensate crowd!
#condensates
#phaseseparation
#granules
#IDPs

The Martin lab has an open postdoc position at the interface of #cytoskeleton and #condensate biology, in a fantastic research community!

If interested, do not hesitate to contact us: mocel.unige.ch/research-gro...

Please RT!

🔊☎️Calling the hive mind of the #Condensate Community of #bluesky: Join us in curating the CD-CODE!

Do you have a favorite condensate or are researching some that are not yet in cd-code.org?

We want your input and expertise!🧠
🔗Easy sign-up here: cd-code.org/signup
and add a new condensate 🎦⤵️

☝️SG is one of the most populous condensate in CD-CODE, with human (cd-code.org/condensate/D...) and yeast (cd-code.org/condensate/E...) proteomes being the most characterized up to date!
Are you a stress granule expert or enthusiast?
🦉Join us as a curator: cd-code.org/signup

Various species have different Stress Granule proteomes:
🔵Translationally stalled mRNAs,
🔵translation initiation factors,
🔵RNA-binding proteins, and
🔵non-RNA-binding proteins
are among the main constituents of SGs.

🚨Condensate of the Month is Stress Granule!

#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.

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🍂🌿Latest #CDCODE release:
🥳Version 1.07 is here: cd-code.org

🌟We focused on improving #species attributions and updating missing #condensate features.

Help us with your condensate expertise!🧠
Join us to become a contributor: cd-code.org/signup