CD-CODE v2.2 RELEASE is live🤩

Our #database grew:
💡10 new #condensates
💡639 new #condensate - #protein connections
💡107 new c-mods
💡10 new #condensatopathies

🟣Find your favorite condensate cd-code.org and 👀see more details about the #release: cd-code.org/release

#cdcode #IDP #RBP #DatabaseUpdate

[2024 OPEN ACCESS]
Room temperature ballistic transport of exciton-polaritons in a one-dimensional whispering gallery microcavity
2024 Appl. Phys. Express 17 112001

iopscience.iop.org/article/10.3...

#APEX
#Physics
#OpenAccess
#polariton
#ballistic
#condensate
#spectroscopy

Phase-separating fusion proteins drive cancer by upsetting transcription regulation - Genome Biology Background Numerous cellular processes rely on biomolecular condensates formed through liquid–liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with ...

Catching up after not being too active recently:
In one of our most #interdisciplinary #multimodal research articles published last year, we demonstrated that #LLPS #condensate dysregulation is very widespread in somatic #cancer. We also provided mechanistic explanations for #oncofusion #proteins.

Maria Hondele @mariahondele.bsky.social @biozentrum.unibas.ch @unibas.ch and co-workers show that fluorescent protein and peptide tags alter #condensate formation and dynamics in vivo and in vitro.

-> www.embopress.org/doi/full/10....

Constructing synthetic nuclear architectures via transcriptional condensates in a DNA protonucleus - Nature Communications Nuclear biomolecular condensates are functional sub-compartments within the cell nucleus. Here, the authors develop a synthetic DNA protonucleus that enables RNA transcription and condensation into di...

🚨Miao's and Weixiang's work on RNA transcription in DNA based condensates as nucleus mimics is now out in @natcomms.nature.com www.nature.com/articles/s41...
#syncell #DNA #condensate #LLPS.
Great work to understand transcription and LLPS in #crowded #viscoelastic environments @sfb1551.bsky.social

Our latest, now in print @jclinical-invest.bsky.social (w/ cover! 🎉) Led by @caryboyd.bsky.social , we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate 🫧 that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/

On extracellular #biomolecular condensates!

We demonstrate that phase-separated #condensate #droplets can form and function in the #extracellular environment and may interact with cells!
www.sciencedirect.com/science/arti...
#CellBiology #Biophysics #ChemicalEngineering #SyntheticBiology #ChemSky

Molecular mechanisms of biomolecular condensate formation in Drosophila melanogaster siRNA biogenesis Abstract. Biogenesis of small interfering RNAs (siRNA) in Drosophila melanogaster involves the processing of double-stranded RNA (dsRNA) by Dcr-2 with Loqs

New paper in collaboration with the Förstemann Lab & Boekhoven Lab is out! Combining #NMR & mutational analysis, we characterize the unique features of the #Ago2 IDR region which drives Ago2/RNA #condensate formation.
doi.org/10.1093/nar/...
@clarahipp.bsky.social

#MustRead for the #condensate aficionados
Solvation is finally getting the attention it deserves

Super read for anyone who's ever looked at their nuclear #condensate and wondered why it wasn't round like everyone else's...

RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination Transcriptional condensates (TCs), enriched with Mediator, orchestrate super-enhancer (SE)-driven gene expression critical for cell identity. However, how their dynamic physical properties shape trans...

#RNA #Condensate #RNAExosome #RNADecay

www.biorxiv.org/content/10.1...

The mRNA-binding protein HLN1 enhances drought stress tolerance by stabilizing the GAD2 mRNA in Arabidopsis - Stress Biology Drought is a common environmental condition that significantly impairs plant growth. In response to drought, plants close their stomata to minimize transpiration and meanwhile activate many stress-res...

The mRNA-binding protein HLN1 enhances drought stress tolerance by stabilizing the GAD2 mRNA in Arabidopsis
Chuangfeng Liu, Yang Wang ... Yiji Xia, Liming Xiong

link.springer.com/article/10.1...

#RBP #Condensate #GABA #AbioticStress

For those interested in topological analysis of biomolecular condensates!

Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...

#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience

Iraq sees rise in natural gas production and condensate availability © Reuters. Investing.com -- Iraq’s Deputy Prime Minister for Energy Affairs and Minister of Oil has announced a rise in natural gas production and the implementation of associated gas capture projects in the country. This news was shared in a statement issued on Wednesday. The initiatives, which aim to cut back on flaring and meet local energy demands, have resulted in a significant availability of condensates. The volume of these condensates, a form of ultra-light oil, has reached approximately 160,000 barrels per day, according to the statement from the Iraqi oil ministry. Condensate is typically processed at splitters to generate petrochemical feedstock naphtha or is used as a diluent for heavy crude oil. The statement also revealed that the majority of the produced condensates are blended with crude oil to improve their specifications. This surge in condensate production signifies a substantial step in Iraq’s strategy to optimize its energy resources. It also reflects the country’s commitment to reducing environmental impact through better gas capture and use. This article was generated with the support of AI and reviewed by an editor. For more information see our T&C. 0 Latest comments

Click Subscribe #Iraq #NaturalGas #EnergyProduction #OilIndustry #Condensate

For #condensate folks 👀
Our study tackles a key gap: how condensate composition is regulated.
These p62 bodies require PARP14—but it’s not just presence that matters.
It’s PARP14’s enzymatic activity that drives formation.
In fact, more PARP14 without activity ≠ condensation.

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🍃CD-CODE update v1.09 is here!🍃

👀Check out the new #biomolecular #condensates at cd-code.org
👀We're continuing to update #Protein - #condensate connections and resolve issues!

Join us to share your #condensate #expertise as a contributor: cd-code.org/signup

#Bioinformatics #DatabaseUpdate #IDR

Here, we identify three novel regulators of #oogenesis in #zebrafish - mTOR, Stat3, and Stathmin, with unpredicted roles in controlling oocyte polarity and formation of the Balbiani body, a conserved oocyte #condensate.
>

Hello Bluesky 🤠
Our very first post is about our recent paper in Nucleic Acids Research: so-called PUN motifs are repetitive elements enabling proteins to catalyze #RNA folding and RNA-dependent #condensate formation ( #LLPS). 15% of human proteins contain 3 or more PUN motifs. See bit.ly/4fZ3f54.

we've updated CD-CODE
#condensate
database to its ❄️winter❄️ version :)
go check if your favorite condensate made it through! no?
add it yourself and help us keep the CD-CODE updated 💟 cd-code.org/signup

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✨Winter CD-CODE update to v1.08!✨

❄️ New #biomolecular #condensates added (total ⚪: 680)
❄️ #Protein - #condensate connections updated
❄️ Species attributes fixed 🤩

👀Check the current version here: cd-code.org
Join us to become a contributor: cd-code.org/signup

#DatabaseUpdate #Bioinformatics #IDR

Inspiring talk by Evan Spruijt at NWO Chain 2024! He shared exciting insights into how coacervate-based and liposome-based #protocells come together to facilitate complex chemistry related to the origin of life on Earth!

#Evolution #OriginofLife #Biomolecular #Condensate #ChemSky

🔊☎️Calling the hive mind of the #Condensate Community of #bluesky: Join us in curating the CD-CODE!

Do you have a favorite condensate or are researching some that are not yet in cd-code.org?

We want your input and expertise!🧠
🔗Easy sign-up here: cd-code.org/signup
and add a new condensate 🎦⤵️

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🍂🌿Latest #CDCODE release:
🥳Version 1.07 is here: cd-code.org

🌟We focused on improving #species attributions and updating missing #condensate features.

Help us with your condensate expertise!🧠
Join us to become a contributor: cd-code.org/signup

The Martin lab has an open postdoc position at the interface of #cytoskeleton and #condensate biology, in a fantastic research community!

If interested, do not hesitate to contact us: mocel.unige.ch/research-gro...

Please RT!