🧵3/6 - N* is a double-stranded RNA binding protein that blunts various human antiviral pathways.
Most interestingly, N* is VERY good at blocking #StressGranules and #RLBs, and it does so by sequestering double-stranded RNAs.
☕Smith and Bartel show that #mRNA recruitment to #StressGranules imparts resistance to the integrated stress response translational shutdown.
bit.ly/45WSNbP
Very much similar to stress granule condensates in animal cells, mRNA storage within aggresomes confers an advantage for bacterial survival and recovery from stress.
#stressgranules #stressresistance
The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth, say Daniel Caballero, Benjamin Tu and colleagues (University of Texas Southwestern Medical Center): rupress.org/jcb/article/...
#Metabolism #Mitochondria #Autophagy #StressGranules
Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules
www.science.org/doi/full/10....
Interested in joining the group as a motivated Master's or PhD student?
Reach out to Dr. Nina Ripin at nina.ripin(at)ur.de.
More news and job ads coming soon – stay tuned! 🚀
#RNA #Condensates #StressGranules #G3BP1
@nature.com @ox.ac.uk @mplsoxford.bsky.social @oxfordchemistry.bsky.social @kavlifoundation.org #ALS #Neurodegeneration #StressGranules #Proteomics #DrugDiscovery
Sridevi Challa et al. show that RACK1 MARylation regulates translation and #StressGranules in #OvarianCancer cells. rupress.org/jcb/article/...
📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25
Acetic acid–induced #StressGranules function as scaffolding complexes for Hog1 activation by Pbs2, say Jongmin Lee, Kazuo Tatebayashi, and David Levin. rupress.org/jcb/article/...
#CellSignaling #Genetics
#RNAbindingproteins (RBPs):
On day 3️⃣ of the #EMBLRBP meeting, we are excited to learn about RBPs in #BiologicalCondensates and the implications for disease!
#StressGranules #Neurodegeneration #PhaseSeparation
@events.embl.org
Lee, Tatebayashi & Levin reveal that #StressGranules induced by acetic acid exposure function as a scaffold to bring the yeast SAPK Hog1 together with its activating kinase Pbs2 without stimulation of the canonical HOG pathway beyond basal levels. rupress.org/jcb/article/...
Stress Granules: The Possible Hidden Trigger in Alzheimer's Disease
#AlzheimersResearch #Neurodegeneration #StressGranules
🚨Condensate of the Month is Stress Granule!
#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.
