🎉 Thrilled - our new Nature Chemistry paper identifying H3K9acOH, a new histone PTM formed by JmjC oxygenase KDM3A - revealing an O2‑dependent PTM in chromatin regulation. Congrats to CRUK KDM team in the Kawamura & Schofield groups & thanks to our amazing collaborators! 📄 rdcu.be/fdx4f #Epigenetics

Sclerotinia sclerotiorum infection establishes cellular hypoxia in Brassica napus.

Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway

Lin et al.

nph.onlinelibrary.wiley.com/doi/10.1111/...

Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway Click on the article title to read more.

The N-degron pathways move from basic to applied science.
This pathway will prove to be of key importance for agricultural improvement. Very happy to have been a part of this work led by Chen Lin and colleagues. #plantscience #nendrule #hypoxia
nph.onlinelibrary.wiley.com/doi/10.1111/...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...

New publication from Markus Wirtz and colleagues on N-terminal protein acetylation: www.nature.com/articles/s41...

🌱 CRAG launches an international call for early‑career researchers!
We invite young scientists interested in starting their independent research group at CRAG

📅 Deadline - April 26

Apply now 👉 https://f.mtr.cool/jdwzombrbd

Proteostasis UK Logo Competition

Design our new logo and win registration, UK‑based travel, and accommodation to attend the UK Proteostasis Meeting 2026, 20–21 July at The Francis Crick Institute, London.

See here for more information:
proteostasisuk.co.uk/calls/proteo...
Deadline: 1st May 2026

I am definitely where I belong! So proud of me right now 🥰 and grateful of my support system in this team 🥂!

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...

Finally officially out!!

www.pnas.org/doi/10.1073/...

We moved the main oxygen sensing machinery from plants to yeast and we learned a few things!

What features are required to shape hypoxic niches enclosing meristems? We @viktoriiavoloboeva.bsky.social in collab @pieterverboven.bsky.social found that a combination of cuticle barrier, densely packed tissue and metabolic activity all uniquely contribute to maintain shoot apical meristem hypoxia

Marsh Clubmoss rediscovered in Dunbartonshire by @bsbiscotland.bsky.social of @bsbibotany.bsky.social

Asgard #archaea: have we found our microbial ancestors?
New review (also for newcomers to the field!) by Christa Schleper and Thiago Rodrigues-Oliveira
link.springer.com/article/10.1...

In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors All organisms fuel and build themselves through their energy metabolism. While classic biochemistry conceptualizes the fluxes of energy and matter, our understanding of how energy metabolism works in ...

Freshly online 🗞️
In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors 🌱🔋🌈🔬

@jan-oleniemeier.bsky.social
@morganlab-saarland.bsky.social
@uni-muenster.de
doi.org/10.1146/annu...

Crossing Arabidopsis thaliana plants

Back to crossing, this time with the horrible mutant nia1 nia2 #arabidopsis #genetics #plantscience

I'd like to remind everyone that CAM has evolved as many if not more times than C4. There are entire biomes where CAM is dominant. If you like tequila, or pineapple, or your pretty orchid you got at the grocery store, you can thank CAM.

Thank you for coming to my TEDtalk. Or CAMtalk as it were.

Rewiring an E3 ligase enhances cold resilience and phosphate use in maize - Nature The E3 ubiquitin ligase NLA postively regulates cold tolerance and negatively regulates phosphate uptake in maize, and a genetically engineered variant of this enzyme leads to improved cold ...

Rewiring an E3 #ligase enhances #cold resilience and #phosphate use in #maize

www.nature.com/articles/s41...

#PlantScience #SciComm @nature.com @natcellbio.nature.com @maizesausage.bsky.social @plantnerd.bsky.social @jchrispires.bsky.social @mrillig.bsky.social @nmouquet.bsky.social

Switching on and off the hypoxic response in plants Abstract. Hypoxia significantly impacts plant metabolism and growth by disrupting mitochondrial respiration, and oxygen sensing plays a vital role in regul

Switching on and off the #hypoxic response in #plants

academic.oup.com/jxb/advance-...

#PlantScience #SciComm @jxbotany.bsky.social @olmiemma.bsky.social @theplantlab.bsky.social @isplore.bsky.social @n-end-rules.bsky.social @hartman-plantlab.com @plantstress.bsky.social @plantredox.bsky.social

Switching on and off the hypoxic response in plants Abstract. Hypoxia significantly impacts plant metabolism and growth by disrupting mitochondrial respiration, and oxygen sensing plays a vital role in regul

Switching on and off the hypoxic response in plants url: academic.oup.com/jxb/article/...

Reversible phosphorylation of NPH3/RPT2-like proteins regulates phototropin receptor signaling Phototropin receptor signaling requires PP2C19 and PP2C35 to dephosphorylate NPH3 and related substrates, ensuring efficient phototropism and chloroplast m

Feeling blue? Find out more about the dark side of phototropin signalling 😀 academic.oup.com/plcell/advan...

🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪

One as Head of Plant Science at Leeds
The new Plant Sciences page is now live and linked to from the FBS Research and Innovation homepage - interested in joining or collaborating? Learn about the research and opportunities by visiting this website! biologicalsciences.leeds.ac.uk/plant-sciences

Switching on and off the hypoxic response in plants Abstract. Hypoxia significantly impacts plant metabolism and growth by disrupting mitochondrial respiration, and oxygen sensing plays a vital role in regul

Happy to see our review online in @jxbotany.bsky.social 🌱

In this work, we provide an overview of the molecular mechanisms plants use to survive under low oxygen stress and during recovery after reoxygenation 🌊

doi.org/10.1093/jxb/...

Co-translational control of protein stability and quality in plants Abstract. Proteostasis relies on the coordinated control of protein synthesis, folding, modification and degradation, and an increasingly clear picture is

My review “Co-translational control of protein stability and quality in plants” is now online at @jxbotany.bsky.social, in which I describe how co-translational processing and ribosome-associated quality control together establish protein stability and fate early in synthesis. tinyurl.com/5dhhz9h6

I completely agree. However, I’ve found that several Chinese researchers publishing impactful work recently haven't responded to my invitations. If you have other recommendations—perhaps colleagues who are particularly active—please let me know!

Protein event of the year - sign up today! See you at beautiful Palazzo dei Normanni in Palermo for the FEBS 2026 Protein Termini Workshop.
#ProteinTermini #Proteostasis #ProteinModifications #StructuralBiology #PalazzoDeiNormanni #Palermo2026
proteintermini.org/meeting/

8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé | #chaperones #degradation #ubiquitin #cryoEM #acetylation #lipidation #ribosomes #proteins
proteintermini.org/meeting/

Join us in Palermo!
FEBS Workshop Protein Termini 2026: the power of protein termini across bacteria, plants, and animals—from ribosome biology to proteostasis and applications. Deadline: 3 March 2026
proteintermini.org/meeting
#ProteinTermini #Proteostasis #FEBS #EMBO @iubmb.bsky.social

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

Sad to say that after 14 years of service the vseed server vseed.nottingham.ac.uk will soon be retired. Do not despair our community resource for seed germination network analysis is still available at netvis.ico2s.org/dev/seednet/#/ thanks to Professor Natalio Krasnogor at Newcastle University

Surprisingly: "Conditional stability of HY5 through the ATE N-degron pathway regulates environmental responses in Arabidopsis thaliana".
The shining bounds of N-degron pathway influence expands! @charlene-kunaka.bsky.social www.biorxiv.org/content/10.6...